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Original Articles
- Diabetes
- Association between White Blood Cell Counts within Normal Range and Hemoglobin A1c in a Korean Population
- Jae Won Hong, Jung Hyun Noh, Dong-Jun Kim
- Endocrinol Metab. 2018;33(1):79-87. Published online January 30, 2018
- DOI: https://doi.org/10.3803/EnM.2018.33.1.79
- 4,588 View
- 51 Download
- 5 Web of Science
- 6 Crossref
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Abstract
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ePub Background We examined whether white blood cell (WBC) count levels within normal range, could be associated with hemoglobin A1c (HbA1c) levels.
Methods Among the 11,472 people (≥19 years of age) who participated in the 2011 to 2012 Korea National Health and Nutrition Examination, subjects with chronic disease or illness, including 807 patients with diabetes currently taking anti-diabetic medications and/or 1,149 subjects with WBC levels <4,000 or >10,000/µL were excluded.
Results Overall, adjusted HbA1c levels increased across the WBC quartiles (5.55%±0.01%, 5.58%±0.01%, 5.60%±0.01%, and 5.65%±0.01%,
P <0.001) after adjusting for confounding factors, such as age, gender, fasting plasma glucose, college graduation, smoking history, waist circumference, presence of hypertension, serum total cholesterol, serum triglyceride, and presence of anemia. The adjusted proportions (%) of HbA1c levels of ≥5.7%, ≥6.1%, and ≥6.5% showed significant increases across WBC quartiles (P <0.001,P =0.002, andP =0.022, respectively). Logistic regression analyses of WBC quartiles for the risk of HbA1c levels of ≥5.7%, ≥6.1%, and ≥6.5%, using the variables above as covariates, showed that the odds ratios of the fourth quartile of WBCs were 1.59 (95% confidence interval [CI], 1.35 to 1.89;P <0.001), 1.78 (95% CI, 1.31 to 2.42;P <0.001), and 2.03 (95% CI, 1.13 to 3.64;P =0.018), using the first quartile of WBCs as the reference.Conclusion HbA1c levels were positively associated with WBC levels within normal range in a general adult population.
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Citations
Citations to this article as recorded by
- Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in diabetes mellitus
Asma Akhter, Sultan Alouffi, Uzma Shahab, Rihab Akasha, Mohd Fazal-Ur-Rehman, Mohamed E. Ghoniem, Naved Ahmad, Kirtanjot Kaur, Ramendra Pati Pandey, Ahmed Alshammari, Firoz Akhter, Saheem Ahmad
Archives of Biochemistry and Biophysics.2024; 753: 109911. CrossRef - Glucose indices as inflammatory markers in children with acute surgical abdomen: a cross-sectional study
Hoda Atef Abdelsattar Ibrahim, Sherif Kaddah, Sara Mohamed Elkhateeb, Abeer Aboalazayem, Aya Ahmed Amin, Mahmoud Marei Marei
Annals of Medicine.2023;[Epub] CrossRef - Factors associated with relative muscle strength in patients with type 2 diabetes mellitus
Chiao-Nan Chen, Ting-Chung Chen, Shiow-Chwen Tsai, Chii-Min Hwu
Archives of Gerontology and Geriatrics.2021; 95: 104384. CrossRef - Non-vascular contributing factors of diabetic foot ulcer severity in national referral hospital of Indonesia
Em Yunir, Dicky L. Tahapary, Tri Juli Edi Tarigan, Dante Saksono Harbuwono, Yoga Dwi Oktavianda, Melly Kristanti, Eni Iswati, Angela Sarumpaet, Pradana Soewondo
Journal of Diabetes & Metabolic Disorders.2021; 20(1): 805. CrossRef - Association between Inflammatory Markers and Glycemic Control in Korean Diabetic Patients
Min Kang, Seok-Joon Sohn
Journal of Health Informatics and Statistics.2021; 46(3): 247. CrossRef - Prediabetes Is Independently Associated with Subclinical Carotid Atherosclerosis: An Observational Study in a Non-Urban Mediterranean Population
Maria Belén Vilanova, Josep Franch-Nadal, Mireia Falguera, Josep Ramon Marsal, Sílvia Canivell, Esther Rubinat, Neus Miró, Àngels Molló, Manel Mata-Cases, Mònica Gratacòs, Esmeralda Castelblanco, Dídac Mauricio
Journal of Clinical Medicine.2020; 9(7): 2139. CrossRef
- Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in diabetes mellitus
- Adrenal gland
- Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly
- Hye Yoon Park, In Ryang Hwang, Jung Bum Seo, Su Won Kim, Hyun Ae Seo, In Kyu Lee, Jung Guk Kim
- Endocrinol Metab. 2015;30(3):312-317. Published online January 5, 2015
- DOI: https://doi.org/10.3803/EnM.2015.30.3.312
- 3,900 View
- 35 Download
- 7 Web of Science
- 5 Crossref
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Abstract
PDFPubReader
Background This study investigated the association between the frequency of growth hormone receptor (GHR) exon 3 polymorphism (exon 3 deletion; d3-GHR) and metabolic factors in patients with acromegaly in Korea.
Methods DNA was extracted from the peripheral blood of 30 unrelated patients with acromegaly. GHR genotypes were evaluated by polymerase chain reaction and correlated with demographic data and laboratory parameters.
Results No patient had the d3/d3 genotype, while four (13.3%) had the d3/fl genotype, and 26 (86.7%) had the fl/fl genotype. Body mass index (BMI) in patients with the d3/fl genotype was significantly higher than in those with the fl/fl genotype (
P =0.001). Age, gender, blood pressure, insulin-like growth factor-1, growth hormone, fasting plasma glucose, triglycerides, high density lipoprotein cholesterol, and low density lipoprotein cholesterol levels showed no significant differences between the two genotypes.Conclusion The d3-GHR polymorphism may be associated with high BMI but not with other demographic characteristics or laboratory parameters.
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Citations
Citations to this article as recorded by- The Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism—A Favorable Backdoor Mechanism for the GHR Function
Ghadeer Falah, Lital Sharvit, Gil Atzmon
International Journal of Molecular Sciences.2023; 24(18): 13908. CrossRef - Gender Specificity and Local Socioeconomic Influence on Association of GHR fl/d3 Polymorphism With Growth and Metabolism in Children and Adolescents
Xiaotian Chen, Chunlan Liu, Song Yang, Yaming Yang, Yanchun Chen, Xianghai Zhao, Weiguang Zhu, Qihui Zhao, Chuan Ni, Xiangyuan Huang, Weili Yan, Chong Shen, Harvest F. Gu
Frontiers in Pediatrics.2022;[Epub] CrossRef - Exon 3-deleted growth hormone receptor isoform is not related to worse bone mineral density or microarchitecture or to increased fracture risk in acromegaly
J. Pontes, M. Madeira, C. H. A. Lima, L. L. Ogino, F. de Paula Paranhos Neto, L. M. C. de Mendonça, M. L. F. Farias, L. Kasuki, M. R. Gadelha
Journal of Endocrinological Investigation.2020; 43(2): 163. CrossRef - MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?
Reetobrata Basu, Yanrong Qian, John J Kopchick
European Journal of Endocrinology.2018; 178(5): R155. CrossRef - MECHANISMS IN ENDOCRINOLOGY: Clinical and pharmacogenetic aspects of the growth hormone receptor polymorphism
Cesar L Boguszewski, Edna J L Barbosa, Per-Arne Svensson, Gudmundur Johannsson, Camilla A M Glad
European Journal of Endocrinology.2017; 177(6): R309. CrossRef
- The Exon 3-Deleted Growth Hormone Receptor (d3GHR) Polymorphism—A Favorable Backdoor Mechanism for the GHR Function
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