Citations

Citations to this article as recorded by  

• TGF-β signaling in health, disease, and therapeutics
  Ziqin Deng, Tao Fan, Chu Xiao, He Tian, Yujia Zheng, Chunxiang Li, Jie He
  Signal Transduction and Targeted Therapy.2024;[Epub]     CrossRef
• Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols
  Qi Jin, Tongtong Liu, Yuan Qiao, Donghai Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Liang Peng, Yongli Zhan
  Frontiers in Immunology.2023;[Epub]     CrossRef
• Beneficial Effects of a Curcumin Derivative and Transforming Growth Factor-β Receptor I Inhibitor Combination on Nonalcoholic Steatohepatitis
  Kyung Bong Ha, Eun Soo Lee, Na Won Park, Su Ho Jo, Soyeon Shim, Dae-Kee Kim, Chan Mug Ahn, Choon Hee Chung
  Diabetes & Metabolism Journal.2023; 47(4): 500.     CrossRef

Citations

Citations to this article as recorded by  

• Potential role of irisin in digestive system diseases
  Yueming Zhang, Linxian Zhao, Huan Gao, Jinghui Zhai, Yanqing Song
  Biomedicine & Pharmacotherapy.2023; 166: 115347.     CrossRef
• Potential role of irisin in lung diseases and advances in research
  Hongna Dong, Xuejiao Lv, Peng Gao, Yuqiu Hao
  Frontiers in Pharmacology.2023;[Epub]     CrossRef
• Stem bark of Fraxinus rhynchophylla ameliorates the severity of pancreatic fibrosis by regulating the TGF-β/Smad signaling pathway
  Ji-Won Choi, Joon Yeon Shin, Ziqi Zhou, Dong-Uk Kim, Bitna Kweon, Hyuncheol Oh, Youn-Chul Kim, Ho-Joon Song, Gi-Sang Bae, Sung-Joo Park
  Journal of Investigative Medicine.2022; 70(5): 1285.     CrossRef
• Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
  Li Zhou, Zhe Zhang, Edouard Nice, Canhua Huang, Wei Zhang, Yong Tang
  Journal of Hematology & Oncology.2022;[Epub]     CrossRef
• Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway
  Yan-fang Deng, Qian-qian Xu, Tian-qi Chen, Jia-xiong Ming, Ya-fen Wang, Li-na Mao, Jia-jun Zhou, Wei-guang Sun, Qun Zhou, Hong Ren, Yong-hui Zhang
  Phytomedicine.2022; 104: 154241.     CrossRef
• The potential role of FNDC5/irisin in various liver diseases: awakening the sleeping beauties
  Xiaoyu Wang, Lihong Mao, Chaoqun Li, Yangyang Hui, Zihan Yu, Mingyu Sun, Yifan Li, Gaoyue Guo, Wanting Yang, Binxin Cui, Xiaofei Fan, Chao Sun
  Expert Reviews in Molecular Medicine.2022;[Epub]     CrossRef
• The Effects of Irisin on the Interaction between Hepatic Stellate Cell and Macrophage in Liver Fibrosis
  Dinh Vinh Do, So Young Park, Giang Thi Nguyen, Dae Hee Choi, Eun-Hee Cho
  Endocrinology and Metabolism.2022; 37(4): 620.     CrossRef
• Hepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk
  Kenneth Pasmans, Michiel E. Adriaens, Peter Olinga, Ramon Langen, Sander S. Rensen, Frank G. Schaap, Steven W. M. Olde Damink, Florian Caiment, Luc J. C. van Loon, Ellen E. Blaak, Ruth C. R. Meex
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Physiopathology of Lifestyle Interventions in Non-Alcoholic Fatty Liver Disease (NAFLD)
  David Carneros, Guillermo López-Lluch, Matilde Bustos
  Nutrients.2020; 12(11): 3472.     CrossRef

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease that is characterized by the formation of heterotopic bone tissues in soft tissues, such as skeletal muscle, ligament, and tendon. It is difficult to remove such heterotopic bones via internal medicine or invasive procedures. The identification of activin A receptor, type I (ACVR1)/ALK2 gene mutations associated with FOP has allowed the genetic diagnosis of FOP. The ACVR1/ALK2 gene encodes the ALK2 protein, which is a transmembrane kinase receptor in the transforming growth factor-β family. The relevant mutations activate intracellular signaling in vitro and induce heterotopic bone formation in vivo. Activin A is a potential ligand that activates mutant ALK2 but not wild-type ALK2. Various types of small chemical and biological inhibitors of ALK2 signaling have been developed to establish treatments for FOP. Some of these are in clinical trials in patients with FOP.

Citations

Citations to this article as recorded by  

• How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva
  Dushyanth Srinivasan, Martin Arostegui, Erich J. Goebel, Kaitlin N. Hart, Senem Aykul, John B. Lees-Shepard, Vincent Idone, Sarah J. Hatsell, Aris N. Economides
  Biomolecules.2024; 14(1): 101.     CrossRef
• Fibrodysplasia Ossificans Progressiva Mimics Generalized Dystonia Disorder: A Case Report
  Seraj Makkawi, Osama Khojah, Reema Abualnaja, Abdulaziz Qashqari, Nawaf A Alahmadi, Abdullatif G Bshnaq, Abdulrahman Alharthi, Hashem H Al-Hashemi, Aiman M Shawli
  Cureus.2023;[Epub]     CrossRef
• Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites
  Hiroyuki Yamazaki
  Journal of Natural Medicines.2022; 76(1): 1.     CrossRef
• A Novel De Novo Frameshift Pathogenic Variant in the FAM111B Resulting in Progressive Osseous Heteroplasia Phenotype
  Anna Ryabets-Lienhard, Panadeekarn Panjawatanan, Kyle Vogt, Jianling Ji, Senta Georgia, Pisit Pitukcheewanont
  Calcified Tissue International.2022; 112(4): 518.     CrossRef
• Inhibitory effects of sesquiterpene lactones from the Indonesian marine sponge Lamellodysidea cf. herbacea on bone morphogenetic protein-induced osteoblastic differentiation
  Satoshi Ohte, Hiroyuki Yamazaki, Ohgi Takahashi, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Huiping Zhang, Fumiaki Hayashi, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchid
  Bioorganic & Medicinal Chemistry Letters.2021; 35: 127783.     CrossRef
• Genomic Context and Mechanisms of the ACVR1 Mutation in Fibrodysplasia Ossificans Progressiva
  Roberto Ravazzolo, Renata Bocciardi
  Biomedicines.2021; 9(2): 154.     CrossRef
• New insights on fibrodysplasia ossificans progressiva: discussion of an autoptic case report and brief literature review
  Vittorio Bolcato, Claudia Carelli, Silvia Damiana Visonà, Marcella Reguzzoni, Maja Di Rocco, Alessandra Radogna, Livio Pietro Tronconi, Matteo Moretti
  Intractable & Rare Diseases Research.2021; 10(2): 136.     CrossRef
• Accumulated Knowledge of Activin Receptor-Like Kinase 2 (ALK2)/Activin A Receptor, Type 1 (ACVR1) as a Target for Human Disorders
  Takenobu Katagiri, Sho Tsukamoto, Mai Kuratani
  Biomedicines.2021; 9(7): 736.     CrossRef
• Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases
  Wojciech Michał Ciszewski, Marta Ewelina Wawro, Izabela Sacewicz-Hofman, Katarzyna Sobierajska
  International Journal of Molecular Sciences.2021; 22(21): 11607.     CrossRef
• Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate
  Juliana Souza Vieira, Emanuelle Juliana Cunha, Juliana Feltrin de Souza, Luis Henrique Koeler Chaves, Jessica Lakes de Souza, Allan Fernando Giovanini
  World Journal of Experimental Medicine.2020; 10(1): 1.     CrossRef
• ALK2: A Therapeutic Target for Fibrodysplasia Ossificans Progressiva and Diffuse Intrinsic Pontine Glioma
  Katsuhiko Sekimata, Tomohiro Sato, Naoki Sakai
  Chemical and Pharmaceutical Bulletin.2020; 68(3): 194.     CrossRef
• Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint Diseases
  Riko Nishimura, Kenji Hata, Yoshifumi Takahata, Tomohiko Murakami, Eriko Nakamura, Maki Ohkawa, Lerdluck Ruengsinpinya
  International Journal of Molecular Sciences.2020; 21(4): 1340.     CrossRef
• Design of primers for direct sequencing of nine coding exons in the human ACVR1 gene
  Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
  Bone.2020; 138: 115469.     CrossRef
• A new diketopiperazine-like inhibitor of bone morphogenetic protein-induced osteoblastic differentiation produced by marine-derived Aspergillus sp. BFM-0085
  Satoshi Ohte, Takehiro Shiokawa, Nobuhiro Koyama, Takenobu Katagiri, Chiaki Imada, Hiroshi Tomoda
  The Journal of Antibiotics.2020; 73(8): 554.     CrossRef
• Penicillic Acid Congener, a New Inhibitor of BMP-Induced Alkaline Phosphatase Activity in Myoblasts, Produced by the Fungus Penicillium sp. BF-0343
  Nobuhiro Koyama, Yasuhiro Otoguro, Satoshi Ohte, Takenobu Katagiri, Hiroshi Tomoda
  Natural Product Communications.2020; 15(9): 1934578X2094265.     CrossRef
• Fibrodysplasia ossificans progressiva: current concepts from bench to bedside
  Arun-Kumar Kaliya-Perumal, Tom J. Carney, Philip W. Ingham
  Disease Models & Mechanisms.2020;[Epub]     CrossRef
• Clinical Aspects and Current Therapeutic Approaches for FOP
  Hiroshi Kitoh
  Biomedicines.2020; 8(9): 325.     CrossRef
• Screening for Small Molecule Inhibitors of BMP-Induced Osteoblastic Differentiation from Indonesian Marine Invertebrates
  Hiroyuki Yamazaki, Satoshi Ohte, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchida
  Marine Drugs.2020; 18(12): 606.     CrossRef
• Propranolol and ascorbic acid in control of fibrodysplasia ossificans progressiva flare-ups due to accidental falls
  Durval Batista Palhares, Deborah Ribeiro Nascimento, Marilene Garcia Palhares, Suzana Lopes Bomfim Balaniuc, Liane de Rosso Giuliani, Paula Cristhina Niz Xavier, José Mauro Goulart Brum, Fabiana Alves, Francisco Oliveira Vieira, Elaine Maria Souza-Fagunde
  Intractable & Rare Diseases Research.2019; 8(1): 24.     CrossRef
• Late-onset fibrodysplasia ossificans progressiva with atypical presentation: A case report
  Conor M. Cunningham, J. Matthew Royeca, Samuel W. King, Hemant Pandit
  Case Reports in Women's Health.2019; 23: e00134.     CrossRef
• Fibrodysplasia ossificans progressiva: lessons learned from a rare disease
  Gulseren Akyuz, Kardelen Gencer-Atalay, Pinar Ata
  Current Opinion in Pediatrics.2019; 31(6): 716.     CrossRef
• Discovery of Heterotopic Bone-Inducing Activity in Hard Tissues and the TGF-β Superfamily
  Takenobu Katagiri, Sho Tsukamoto, Yutaka Nakachi, Mai Kuratani
  International Journal of Molecular Sciences.2018; 19(11): 3586.     CrossRef

Citations

Citations to this article as recorded by  

• The modulation effects of plant‐derived bioactive ingredients on chronic kidney disease: Focus on the gut–kidney axis
  Shiyan Jian, Kang Yang, Lingna Zhang, Limeng Zhang, Zhongquan Xin, Chaoyu Wen, Shansong He, Jinping Deng, Baichuan Deng
  Food Frontiers.2023; 4(1): 262.     CrossRef
• Druggability of lipid metabolism modulation against renal fibrosis
  Yuan-yuan Chen, Xiao-guang Chen, Sen Zhang
  Acta Pharmacologica Sinica.2022; 43(3): 505.     CrossRef
• Lobeglitazone attenuates fibrosis in corneal fibroblasts by interrupting TGF-beta-mediated Smad signaling
  Selikem Nuwormegbe, Na-Young Park, Sun Woong Kim
  Graefe's Archive for Clinical and Experimental Ophthalmology.2022; 260(1): 149.     CrossRef
• Comparative Efficacy of Lobeglitazone Versus Pioglitazone on Albuminuria in Patients with Type 2 Diabetes Mellitus
  Kyung-Soo Kim, Sangmo Hong, Hong-Yup Ahn, Cheol-Young Park
  Diabetes Therapy.2021; 12(1): 171.     CrossRef
• Lobeglitazone: A Novel Thiazolidinedione for the Management of Type 2 Diabetes Mellitus
  Jaehyun Bae, Taegyun Park, Hyeyoung Kim, Minyoung Lee, Bong-Soo Cha
  Diabetes & Metabolism Journal.2021; 45(3): 326.     CrossRef
• Lobeglitazone, A Peroxisome Proliferator-Activated Receptor-Gamma Agonist, Inhibits Papillary Thyroid Cancer Cell Migration and Invasion by Suppressing p38 MAPK Signaling Pathway
  Jun-Qing Jin, Jeong-Sun Han, Jeonghoon Ha, Han-Sang Baek, Dong-Jun Lim
  Endocrinology and Metabolism.2021; 36(5): 1095.     CrossRef
• Protocol for a preclinical systematic review and meta-analysis of pharmacological targeting of peroxisome proliferator-activated receptors in experimental renal injury
  William P Martin, Yeong H D Chuah, Emer Conroy, Alison L Reynolds, Conor Judge, Francisco J López-Hernández, Carel W le Roux, Neil G Docherty
  BMJ Open Science.2021;[Epub]     CrossRef
• Stevioside inhibits unilateral ureteral obstruction‐induced kidney fibrosis and upregulates renal PPARγ expression in mice
  Wei Shen, Ke Fan, Ying Zhao, Junyan Zhang, Meilin Xie
  Journal of Food Biochemistry.2020;[Epub]     CrossRef
• FBW7 Regulates the Autophagy Signal in Mesangial Cells Induced by High Glucose
  Chenlin Gao, Fang Fan, Jiao Chen, Yang Long, Shi Tang, Chunxia Jiang, Yong Xu
  BioMed Research International.2019; 2019: 1.     CrossRef
• Treatment with Lobeglitazone Attenuates Hepatic Steatosis in Diet-Induced Obese Mice
  Sorim Choung, Kyong Hye Joung, Bo Ram You, Sang Ki Park, Hyun Jin Kim, Bon Jeong Ku
  PPAR Research.2018; 2018: 1.     CrossRef
• VCE‐004.3, a cannabidiol aminoquinone derivative, prevents bleomycin‐induced skin fibrosis and inflammation through PPARγ‐ and CB2 receptor‐dependent pathways
  Carmen del Rio, Irene Cantarero, Belén Palomares, María Gómez‐Cañas, Javier Fernández‐Ruiz, Carolina Pavicic, Adela García‐Martín, Maria Luz Bellido, Rafaela Ortega‐Castro, Carlos Pérez‐Sánchez, Chary López‐Pedrera, Giovanni Appendino, Marco A Calzado, Ed
  British Journal of Pharmacology.2018; 175(19): 3813.     CrossRef
• EHP-101, an oral formulation of the cannabidiol aminoquinone VCE-004.8, alleviates bleomycin-induced skin and lung fibrosis
  Adela García-Martín, Martín Garrido-Rodríguez, Carmen Navarrete, Carmen del Río, María L. Bellido, Giovanni Appendino, Marco A. Calzado, Eduardo Muñoz
  Biochemical Pharmacology.2018; 157: 304.     CrossRef
• Effects of Lobeglitazone, a New Thiazolidinedione, on Osteoblastogenesis and Bone Mineral Density in Mice
  Kyoung Min Kim, Hyun-Jin Jin, Seo Yeon Lee, Hyo Jin Maeng, Gha Young Lee, Tae Jung Oh, Sung Hee Choi, Hak Chul Jang, Soo Lim
  Endocrinology and Metabolism.2017; 32(3): 389.     CrossRef
• Effects of Lobeglitazone, a Novel Thiazolidinedione, on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus over 52 Weeks
  Soo Lim, Kyoung Min Kim, Sin Gon Kim, Doo Man Kim, Jeong-Taek Woo, Choon Hee Chung, Kyung Soo Ko, Jeong Hyun Park, Yongsoo Park, Sang Jin Kim, Hak Chul Jang, Dong Seop Choi
  Diabetes & Metabolism Journal.2017; 41(5): 377.     CrossRef

Bone metastasis is a frequent occurrence in breast cancer, affecting more than 70% of late stage cancer patients with severe complications such as fracture, bone pain, and hypercalcemia. The pathogenesis of osteolytic bone metastasis depends on cross-communications between tumor cells and various stromal cells residing in the bone microenvironment. Several growth factor signaling pathways, secreted micro RNAs (miRNAs) and exosomes are functional mediators of tumor-stromal interactions in bone metastasis. We developed a functional genomic approach to systemically identified molecular pathways utilized by breast cancer cells to engage the bone stroma in order to generate osteolytic bone metastasis. We showed that elevated expression of vascular cell adhesion molecule 1 (VCAM1) in disseminated breast tumor cells mediates the recruitment of pre-osteoclasts and promotes their differentiation to mature osteoclasts during the bone metastasis formation. Transforming growth factor β (TGF-β) is released from bone matrix upon bone destruction, and signals to breast cancer to further enhance their malignancy in developing bone metastasis. We furthered identified Jagged1 as a TGF-β target genes in tumor cells that engaged bone stromal cells through the activation of Notch signaling to provide a positive feedback to promote tumor growth and to activate osteoclast differentiation. Substantially change in miRNA expression was observed in osteoclasts during their differentiation and maturation, which can be exploited as circulating biomarkers of emerging bone metastasis and therapeutic targets for the treatment of bone metastasis. Further research in this direction may lead to improved diagnosis and treatment strategies for bone metastasis.

Citations

Citations to this article as recorded by  

• Osteoclast Cancer Cell Metabolic Cross-talk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer
  Huijuan Fan, Zhanao Xu, Ke Yao, Bingxin Zheng, Yuan Zhang, Xuxiang Wang, Tengjiang Zhang, Xuan Li, Haitian Hu, Bin Yue, Zeping Hu, Hanqiu Zheng
  Cancer Research.2024; 84(3): 449.     CrossRef
• Bone Marrow Mesenchymal Stem Cells Restrain the Migration and Invasion of Breast Cancer Cells by Up-Regulating miR-2158 and Inactivating RAI2/NLRP3 Pathway
  Meiyu Xu, Shen Ye, Zhiqiang Tang, Shuai Gong
  Journal of Biomaterials and Tissue Engineering.2023; 13(1): 162.     CrossRef
• Association of RANKL and EGFR gene expression with bone metastases in patients with metastatic non-small cell lung cancer
  Anita J.W.M. Brouns, Lizza E.L. Hendriks, Iris J. Robbesom-van den Berge, Annemariek J.H.M. Driessen, Guido M.J.M. Roemen, Britt L.J. van Herpen, Zoë Dekkers, Bas Heitzer, Daphne J.G. Leunissen, Laura Moonen, Ragnar Lunde, Marcel Westenend, Marjolein van
  Frontiers in Oncology.2023;[Epub]     CrossRef
• BMAL1 induces colorectal cancer metastasis by stimulating exosome secretion
  Pengjuan Dong, Yaping Wang, Yutong Liu, Chunting Zhu, Jiaxin Lin, Ruizhe Qian, Luchun Hua, Chao Lu
  Molecular Biology Reports.2022; 49(1): 373.     CrossRef
• Chemokines network in bone metastasis: Vital regulators of seeding and soiling
  Gunjan Sharma, Ramesh Pothuraju, Ranjana Kumari Kanchan, Surinder Kumar Batra, Jawed Akhtar Siddiqui
  Seminars in Cancer Biology.2022; 86: 457.     CrossRef
• The Signaling Pathways Associated With Breast Cancer Bone Metastasis
  Xuelian Song, Changran Wei, Xiangqi Li
  Frontiers in Oncology.2022;[Epub]     CrossRef
• Effects of 8-week noncontinuous aerobic exercise on the levels of CCL2, CCL5, and their respective receptors in female BALB/C mice suffering from breast cancer
  Mehrnoosh Esmailiyan, Mehdi Kargarfard, Fahimeh Esfarjani, Golnaz Vaseghi
  International Journal of Preventive Medicine.2022; 13(1): 55.     CrossRef
• Non‐coding RNAs in bone remodelling and bone metastasis: Mechanisms of action and translational relevance
  Margherita Puppo, Hanna Taipaleenmäki, Eric Hesse, Philippe Clézardin
  British Journal of Pharmacology.2021; 178(9): 1936.     CrossRef
• Sympathetic activity in breast cancer and metastasis: partners in crime
  Francisco Conceição, Daniela M. Sousa, Joana Paredes, Meriem Lamghari
  Bone Research.2021;[Epub]     CrossRef
• Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis
  Shenglong Li, Wei Wang
  Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
• Bone marrow niches in the regulation of bone metastasis
  Fenfang Chen, Yujiao Han, Yibin Kang
  British Journal of Cancer.2021; 124(12): 1912.     CrossRef
• Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer
  Kerui Wu, Jiamei Feng, Feng Lyu, Fei Xing, Sambad Sharma, Yin Liu, Shih-Ying Wu, Dan Zhao, Abhishek Tyagi, Ravindra Pramod Deshpande, Xinhong Pei, Marco Gabril Ruiz, Hiroyuki Takahashi, Shunsuke Tsuzuki, Takahiro Kimura, Yin-yuan Mo, Yusuke Shiozawa, Ravi
  Nature Communications.2021;[Epub]     CrossRef
• Circulating Osteocalcin-Positive Cells as a Novel Diagnostic Biomarker for Bone Metastasis in Breast Cancer Patients
  Kyung-Hun Lee, Kyoung Jin Lee, Tae-Yong Kim, Febby Hutomo, Hyun Jin Sun, Gi Jeong Cheon, Serk In Park, Sun Wook Cho, Seock-Ah Im
  Journal of Bone and Mineral Research.2020; 35(10): 1838.     CrossRef
• Polymer nanomedicines
  Jindřich Kopeček, Jiyuan Yang
  Advanced Drug Delivery Reviews.2020; 156: 40.     CrossRef
• Osteolytic metastasis in breast cancer: effective prevention strategies
  Chandi C Mandal
  Expert Review of Anticancer Therapy.2020; 20(9): 797.     CrossRef
• The Tumor Microenvironment of Primitive and Metastatic Breast Cancer: Implications for Novel Therapeutic Strategies
  Giovanni Zarrilli, Gianluca Businello, Maria Vittoria Dieci, Silvia Paccagnella, Valentina Carraro, Rocco Cappellesso, Federica Miglietta, Gaia Griguolo, Valentina Guarneri, Marcello Lo Mele, Matteo Fassan
  International Journal of Molecular Sciences.2020; 21(21): 8102.     CrossRef
• Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer
  Jules A Westbrook, Steven L Wood, David A Cairns, Kathryn McMahon, Renu Gahlaut, Helene Thygesen, Mike Shires, Stephanie Roberts, Helen Marshall, Maria R Oliva, Mark J Dunning, Andrew M Hanby, Peter J Selby, Valerie Speirs, Georgia Mavria, Robert E Colema
  The Journal of Pathology.2019; 247(3): 381.     CrossRef
• The Relationship between Exosomes and Cancer: Implications for Diagnostics and Therapeutics
  Wendy W. Weston, Timothy Ganey, H. Thomas Temple
  BioDrugs.2019; 33(2): 137.     CrossRef
• In Vivo Assessment of VCAM-1 Expression by SPECT/CT Imaging in Mice Models of Human Triple Negative Breast Cancer
  Montemagno, Dumas, Cavaillès, Ahmadi, Bacot, Debiossat, Soubies, Djaïleb, Leenhardt, Leiris, Dufies, Pagès, Hernot, Devoogdt, Perret, Riou, Fagret, Ghezzi, Broisat
  Cancers.2019; 11(7): 1039.     CrossRef
• Notch and breast cancer metastasis: Current knowledge, new sights and targeted therapy (Review)
  Yu Zhang, Zi‑Yan Xie, Xuan‑Tong Guo, Xing‑Hua Xiao, Li‑Xia Xiong
  Oncology Letters.2019;[Epub]     CrossRef
• NPNT promotes early-stage bone metastases in breast cancer by regulation of the osteogenic niche
  Dongsheng Wang, Chenglong Zhao, Liangliang Gao, Yao Wang, Xin Gao, Liang Tang, Kun Zhang, Zhenxi Li, Jing Han, Jianru Xiao
  Journal of Bone Oncology.2018; 13: 91.     CrossRef
• Placental exosomes: A proxy to understand pregnancy complications
  Jin Jin, Ramkumar Menon
  American Journal of Reproductive Immunology.2018;[Epub]     CrossRef
• Understanding the Bone in Cancer Metastasis
  Jaime Fornetti, Alana L Welm, Sheila A Stewart
  Journal of Bone and Mineral Research.2018; 33(12): 2099.     CrossRef
• Role of Tumor-Derived Chemokines in Osteolytic Bone Metastasis
  Salvatore J. Coniglio
  Frontiers in Endocrinology.2018;[Epub]     CrossRef
• The role of exosomes in cancer metastasis
  Teresa Bernadette Steinbichler, József Dudás, Herbert Riechelmann, Ira-Ida Skvortsova
  Seminars in Cancer Biology.2017; 44: 170.     CrossRef
• Articles inEndocrinology and Metabolismin 2016
  Won-Young Lee
  Endocrinology and Metabolism.2017; 32(1): 62.     CrossRef
• Impaired Bone Matrix Alignment Induced by Breast Cancer Metastasis
  Aiko Sekita, Aira Matsugaki, Takayoshi Nakano
  Journal of the Japan Institute of Metals.2017; 81(6): 308.     CrossRef
• SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
  Zhan Xu, Matthew B. Greenblatt, Guang Yan, Heng Feng, Jun Sun, Sutada Lotinun, Nicholas Brady, Roland Baron, Laurie H. Glimcher, Weiguo Zou
  Nature Communications.2017;[Epub]     CrossRef
• Bone Microenvironment and Role of Rank-Rankl-Opg in Breast Cancer Metastasis in Bone
  Hongwei Zhang
  Journal of Cancer Prevention & Current Research.2017;[Epub]     CrossRef
• Tumor–Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic Implications
  Hanqiu Zheng, Wenyang Li, Yibin Kang
  Cold Spring Harbor Symposia on Quantitative Biology.2016; 81: 151.     CrossRef
• Breast cancer cells obtain an osteomimetic featureviaepithelial-mesenchymal transition that have undergone BMP2/RUNX2 signaling pathway induction
  Cong-Cong Tan, Gui-Xi Li, Li-Duan Tan, Xin Du, Xiao-Qing Li, Rui He, Qing-Shan Wang, Yu-Mei Feng
  Oncotarget.2016; 7(48): 79688.     CrossRef
• Heterotypic models of osteosarcoma recapitulate tumor heterogeneity and biological behavior
  Milcah C. Scott, Hirotaka Tomiyasu, John R. Garbe, Ingrid Cornax, Clarissa Amaya, M Gerard O'Sullivan, Subbaya Subramanian, Brad A. Bryan, Jaime F. Modiano
  Disease Models & Mechanisms.2016;[Epub]     CrossRef
• Osteoblasts Are the Centerpiece of the Metastatic Bone Microenvironment
  Hyo Min Jeong, Sun Wook Cho, Serk In Park
  Endocrinology and Metabolism.2016; 31(4): 485.     CrossRef