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2 "Tumor-associated macrophages"
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Original Articles
Endocrine Research
Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
Endocrinol Metab. 2016;31(3):469-475.   Published online August 2, 2016
DOI: https://doi.org/10.3803/EnM.2016.31.3.469
  • 4,746 View
  • 52 Download
  • 22 Web of Science
  • 16 Crossref
AbstractAbstract PDFPubReader   
Background

Tumor associated macrophages (TAMs) and CXC chemokine receptor 4 (CXCR4) have emerged as potential biomarkers in various human cancers. The aims of this study were to investigate the clinical characteristics of anaplastic thyroid cancer (ATC) patients according to the TAM numbers in the tumor tissue, and to evaluate the associations between CXCR4 expressions and macrophage densities in ATC tumor microenvironment.

Methods

Total 14 ATC samples from thyroid tissue microarray were used. Immunohistochemical staining was performed using anti-CD163 and anti-CXCR4 antibodies. According to the immunoreactivity of CD163, all subjects were divided into two groups: low-CD163 (n=8) and high-CD163 (n=6) groups.

Results

The mean diagnostic age was 65±7 years and the median tumor size was 4.3 cm, ranging 2.5 to 15 cm. Clinicopathological characteristics were not significantly different between low-CD163 and high-CD163 groups, while age of diagnosis was younger in high-CD163 group than that of low-CD163 group with marginal significance (56.9±5.5 years vs. 67.5±6.8 years, P=0.09). However, overall survival was significantly reduced in high-CD163 group (5.5 months [range, 1 to 10]) compared with low-CD163 groups (8.8 months [range, 6 to 121); log-rank test, P=0.0443). Moreover, high-CD163 group showed strong CXCR4 expressions in both cancer and stromal compartments, while low-CD163 group showed relatively weak, stromal-dominant CXCR4 expressions. Additionally, CD163 and CXCR4 expressions showed a strong positive correlation (γ2=0.432, P=0.013).

Conclusion

Increased number of TAMs showed poor overall survival in ATC, suggesting TAMs are potentially a prognostic biomarker for ATC. CXCR4 expression was significantly correlated with CD163-positive TAM densities, which suggest the possible role of CXCR4 in TAM recruitments.

Citations

Citations to this article as recorded by  
  • IL2RA+VSIG4+ tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer
    Zongfu Pan, Lisha Bao, Xixuan Lu, Xiaoping Hu, Lu Li, Jinming Chen, Tiefeng Jin, Yiwen Zhang, Zhuo Tan, Ping Huang, Minghua Ge
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(1): 166591.     CrossRef
  • Crosstalk between Thyroid Carcinoma and Tumor-Correlated Immune Cells in the Tumor Microenvironment
    Mingyuan Song, Qi Liu, Wei Sun, Hao Zhang
    Cancers.2023; 15(10): 2863.     CrossRef
  • Modeling the tumor microenvironment of anaplastic thyroid cancer: an orthotopic tumor model in C57BL/6 mice
    Zhen Xu, Hyo Shik Shin, Yoo Hyung Kim, Seong Yun Ha, Jae-Kyung Won, Su-jin Kim, Young Joo Park, Sareh Parangi, Sun Wook Cho, Kyu Eun Lee
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Tumor-associated macrophages as a potential therapeutic target in thyroid cancers
    Liya Zhu, Xiu Juan Li, Prakash Gangadaran, Xiuli Jing, Byeong-Cheol Ahn
    Cancer Immunology, Immunotherapy.2023; 72(12): 3895.     CrossRef
  • Functional Phenotypes of Peritoneal Macrophages Upon AMD3100 Treatment During Colitis-Associated Tumorigenesis
    Shuai Wu, Weiwei Luo, Xing Wu, Zhaohua Shen, Xiaoyan Wang
    Frontiers in Medicine.2022;[Epub]     CrossRef
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    Yi Luo, Yi-Chen Yang, Ben Ma, Wei-Bo Xu, Tian Liao, Yu Wang
    Endocrine.2022; 78(3): 517.     CrossRef
  • Secreted Factors by Anaplastic Thyroid Cancer Cells Induce Tumor-Promoting M2-like Macrophage Polarization through a TIM3-Dependent Mechanism
    Cinthia Carolina Stempin, Romina Celeste Geysels, Sunmi Park, Luz Maria Palacios, Ximena Volpini, Claudia Cristina Motran, Eva Virginia Acosta Rodríguez, Juan Pablo Nicola, Sheue-yann Cheng, Claudia Gabriela Pellizas, Laura Fozzatti
    Cancers.2021; 13(19): 4821.     CrossRef
  • Immunotherapy for anaplastic thyroid carcinoma: the present and future
    Xixuan LU, Lisha BAO, Zongfu PAN, Minghua GE
    Journal of Zhejiang University (Medical Sciences).2021; 50(6): 675.     CrossRef
  • CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy
    Ashraf Mousavi
    Immunology Letters.2020; 217: 91.     CrossRef
  • Nobiletin Alone or in Combination with Cisplatin Decreases the Viability of Anaplastic Thyroid Cancer Cell Lines
    Diana P. Sousa, Marta Pojo, Ana T. Pinto, Valeriano Leite, Ana Teresa Serra, Branca M. Cavaco
    Nutrition and Cancer.2020; 72(2): 352.     CrossRef
  • The Thyroid Tumor Microenvironment: Potential Targets for Therapeutic Intervention and Prognostication
    Laura MacDonald, Jonathan Jenkins, Grace Purvis, Joshua Lee, Aime T. Franco
    Hormones and Cancer.2020; 11(5-6): 205.     CrossRef
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    Iñigo Landa, Jeffrey A. Knauf
    Endocrinology and Metabolism.2019; 34(1): 11.     CrossRef
  • Low Lymphocyte-to-Monocyte Ratios Are Associated with Poor Overall Survival in Anaplastic Thyroid Carcinoma Patients
    Jonghwa Ahn, Eyun Song, Hye-Seon Oh, Dong Eun Song, Won Gu Kim, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Min Ji Jeon
    Thyroid.2019; 29(6): 824.     CrossRef
  • Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy
    Christian M. Schürch, Matthias A. Roelli, Stefan Forster, Marie-Hélène Wasmer, Frido Brühl, Renaud S. Maire, Sergio Di Pancrazio, Marc-David Ruepp, Roland Giger, Aurel Perren, Anja M. Schmitt, Philippe Krebs, Roch-Philippe Charles, Matthias S. Dettmer
    Thyroid.2019; 29(7): 979.     CrossRef
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    Maria E. Cabanillas, Mark Zafereo, Michelle D. Williams, Renata Ferrarotto, Ramona Dadu, Neil Gross, G. Brandon Gunn, Heath Skinner, Gilbert Cote, Horiana B. Grosu, Priyanka Iyer, Naifa L. Busaidy
    F1000Research.2018; 7: 87.     CrossRef
  • Pathological processes and therapeutic advances in radioiodide refractory thyroid cancer
    Marika H Tesselaar, Johannes W Smit, James Nagarajah, Romana T Netea-Maier, Theo S Plantinga
    Journal of Molecular Endocrinology.2017; 59(4): R141.     CrossRef
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Thyroid
The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma
Seunghwan Kim, Sun Wook Cho, Hye Sook Min, Kang Min Kim, Gye Jeong Yeom, Eun Young Kim, Kyu Eun Lee, Yeo Gyu Yun, Do Joon Park, Young Joo Park
Endocrinol Metab. 2013;28(3):192-198.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.192
  • 4,322 View
  • 46 Download
  • 40 Crossref
AbstractAbstract PDFPubReader   
Background

Tumor-associated macrophages (TAMs) play a tumorigenic role related to advanced staging and poor prognosis in many human cancers including thyroid cancers. Yet, a functional role of TAMs in papillary thyroid carcinoma (PTC) has not been established. The aim of this study was to investigate TAM expression in human PTC with lymph node (LN) metastasis.

Methods

Thirty-six patients who underwent surgery after being diagnosed with PTC with LN metastasis were included. Primary tumor tissues were immunohistochemically stained with an anti-CD68 antibody and clinical characteristics according to TAM density were evaluated.

Results

The TAM densities (CD68+ cells) varied from 5% to 70%, in all tumor areas, while few cells were stained in adjacent normal tissues. TAMs were identified as CD68+ cells with thin, elongated cytoplasmic extensions that formed a canopy structure over tumor cells. Comparing clinicopathologic characteristics between tumors with low (<25%) and high (25% to 70%) TAM densities, primary tumors were larger in the high density group than in the low density group (2.0±0.1 vs. 1.5±0.1; P=0.009).

Conclusion

TAMs were identified in primary PTC tumors with LN metastasis and higher TAM densities were related to larger tumor sizes, suggesting a tumorigenic role of TAMs in human PTCs.

Citations

Citations to this article as recorded by  
  • Single-cell RNA-seq reveals MIF−(CD74 + CXCR4) dependent inhibition of macrophages in metastatic papillary thyroid carcinoma
    Wei Chen, Xinnian Yu, Huixin Li, Shenglong Yuan, Yuqi Fu, Huanhuan Hu, Fangzhou Liu, Yuan Zhang, Shanliang Zhong
    Oral Oncology.2024; 148: 106654.     CrossRef
  • H2AFX might be a prognostic biomarker for hepatocellular carcinoma
    Hailiang Hu, Tao Zhong, Suwei Jiang
    Cancer Reports.2023;[Epub]     CrossRef
  • The Tumor Microenvironment and the Estrogen Loop in Thyroid Cancer
    Nerina Denaro, Rebecca Romanò, Salvatore Alfieri, Alessia Dolci, Lisa Licitra, Imperia Nuzzolese, Michele Ghidini, Claudia Bareggi, Valentina Bertaglia, Cinzia Solinas, Ornella Garrone
    Cancers.2023; 15(9): 2458.     CrossRef
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    Yujia Tao, Peng Li, Chao Feng, Yuan Cao
    Immunological Investigations.2023; 52(8): 1039.     CrossRef
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    Qi Liu, Wei Sun, Hao Zhang
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Construction of a Tumor Immune Microenvironment-Related Prognostic Model in BRAF-Mutated Papillary Thyroid Cancer
    Yuxiao Xia, Xue Jiang, Yuan Huang, Qian Liu, Yin Huang, Bo Zhang, Zhanjun Mei, Dongkun Xu, Yuhong Shi, Wenling Tu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Identification and Validation of Prognostic Related Hallmark ATP-Binding Cassette Transporters Associated With Immune Cell Infiltration Patterns in Thyroid Carcinoma
    Lidong Wang, Xiaodan Sun, Jingni He, Zhen Liu
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Unraveling the Effects of Carotenoids Accumulation in Human Papillary Thyroid Carcinoma
    Alessandra di Masi, Rosario Luigi Sessa, Ylenia Cerrato, Gianni Pastore, Barbara Guantario, Roberto Ambra, Michael Di Gioacchino, Armida Sodo, Martina Verri, Pierfilippo Crucitti, Filippo Longo, Anda Mihaela Naciu, Andrea Palermo, Chiara Taffon, Filippo A
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    Frontiers in Endocrinology.2022;[Epub]     CrossRef
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    Ni Wayan Armerinayanti, Samuel Widodo, Desak Putu Oki Lestari
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    International Journal of Molecular Sciences.2022; 23(20): 12578.     CrossRef
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    Elisa Stellaria Grassi, Viola Ghiandai, Luca Persani
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    Marika H Tesselaar, Johannes W Smit, James Nagarajah, Romana T Netea-Maier, Theo S Plantinga
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    Maria Rosaria Galdiero, Gilda Varricchi, Gianni Marone
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  • Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
    Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
    Endocrinology and Metabolism.2016; 31(3): 469.     CrossRef
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  • The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma
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