The Comparison of Clinical Factors according to Growth Velocity during Gonadotropin-Releasing Hormone Agonist Treatment in Central Precocious Puberty Girls.

Hyo Kyoung Nam; Jung Yeon Shin; Yeon Joung Oh; Young Jun Rhie; Young Yoo; Sang Hee Park; Kee Hyoung Lee

doi:10.3803/EnM.2010.25.3.206

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Original Article The Comparison of Clinical Factors according to Growth Velocity during Gonadotropin-Releasing Hormone Agonist Treatment in Central Precocious Puberty Girls.: Hyo Kyoung Nam, Jung Yeon Shin, Yeon Joung Oh, Young Jun Rhie, Young Yoo, Sang Hee Park, Kee Hyoung Lee; Endocrinology and Metabolism 2010;25(3):206-212
DOI: https://doi.org/10.3803/EnM.2010.25.3.206
Published online: September 1, 2010

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¹Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. khlee218@kumc.or.kr
²Department of Pediatrics, Sahm Yook Medical Center, Seoul, Korea.

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Abstract

BACKGROUND
The aim of this study was to investigate the favorable factors for gonadotropin-releasing hormone (GnRH) agonist treatment with regard to the growth velocity and the predicted adult height (PAH) in central precocious puberty (CPP) girls. METHODS: We reviewed the clinical and auxological parameters in 46 CPP girls who were treated with GnRH agonist at the pediatric endocrinology clinic of Korea University Hospital from January 2001 to August 2007. We divided the two groups according to the growth velocity of 5 cm/yr and we assessed the related factors associated with growth velocity. We also assessed the changes in PAH for two years. RESULTS: The pretreatment chronological age and bone age were significantly younger in the high growth velocity group (> 5 cm/yr) compared to that of the low growth velocity group (7.8 +/- 0.9 year vs. 8.4 +/- 0.5 year, 9.4 +/- 1.2 year vs. 10.1 +/- 0.9 year, respectively) (P < 0.05). The PAH after treatment was significantly greater in the high growth velocity group (> 5 cm/yr)(P < 0.05). Growth velocity during treatment had negative correlation with the pretreatment chronological age and positive correlation with the PAH after one and two years of treatment (r = -0.45, P < 0.05 and r = 0.51, P < 0.01). PAH had positive correlation with the treatment duration (r = 0.31, P < 0.05). CONCLUSION: In our study, the growth velocity during GnRH agonist treatment was negatively related to age at the initiation of treatment. Therefore, earlier treatment is important to improve the outcomes and to maintain appropriate growth velocity in CPP girls.

Keywords: Gonadotropin releasing hormone agonist;Growth velocity;Precocious puberty;Predicted adult height;

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Age of menarche and near adult height after long-term gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty
Joon-Woo Baek, Hyo-Kyoung Nam, Dahee Jin, Yeon Joung Oh, Young-Jun Rhie, Kee-Hyoung Lee
Annals of Pediatric Endocrinology & Metabolism.2014; 19(1): 27. CrossRef

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