Table 1Characteristics of Study Population
Variable |
T2DM group (n=38) |
Non-diabetes group (n=75) |
P valuea
|
Sex, male/female |
17/21 |
32/43 |
0.836 |
Age, yr |
50.3±10.8 |
49.3±13.0 |
0.683 |
BMI, kg/m2
|
25.7±4.6 |
24.4±3.7 |
0.136 |
Waist circumferences, cm |
87.0±11.6 |
83.5±10.9 |
0.345 |
Fasting glucose, mg/dL |
176.9±67.7 |
98.9±9.7 |
<0.001 |
Fasting insulin, mIU/L |
11.5±4.3 |
9.8±4.8 |
0.055 |
Fasting C-peptide, mIU/L |
0.88±0.38 |
0.71±0.37 |
0.025 |
Postload 2-hour glucose, mg/dL |
324.5±124.9 |
118.3±30.4 |
<0.001 |
Postload 2-hour insulin, mIU/L |
50.2±43.8 |
52.1±53.3 |
0.846 |
Postload 2-hour C-peptide, mIU/L |
2.76±1.71 |
3.15±1.49 |
0.283 |
HbA1c, % |
8.7±2.4 |
5.4±0.4 |
<0.001 |
HOMA-IR |
4.8±2.2 |
2.4±1.2 |
<0.001 |
HOMA-β |
24.2±15.4 |
32.1±17.0 |
0.016 |
TG, mg/dL |
163.1±108.4 |
134.1±103.1 |
0.184 |
LDL-C, mg/dL |
130.8±42.2 |
120.0±32.9 |
0.182 |
HDL-C, mg/dL |
50.8±13.0 |
55.6±13.7 |
0.084 |
TC, mg/dL |
206.0±48.2 |
195.2±36.6 |
0.240 |
AST, IU/L |
25.1±15.4 |
21.9±7.5 |
0.147 |
ALT, IU/L |
29.5 ± 17.4 |
23.9±16.5 |
0.110 |
eGFR (MDRD), mL/min |
112.2±26.7 |
105.1±18.4 |
0.108 |
ACR (albumin/creatinin ratio) |
51.1±124.7 |
3.98±3.45 |
0.056 |
Hemoglobin, g/dL |
14.6±1.4 |
13.8±1.5 |
0.016 |
SBP, mm Hg |
129.0±11.7 |
125.0±13.7 |
0.125 |
DBP, mm Hg |
79.3±8.6 |
75.4±8.8 |
0.034 |
hs-CRP, mg/L |
4.1±9.9 |
1.2±1.8 |
0.034 |
Apolipoprotein A, mg/dL |
130.6±30.6 |
126.1±25.1 |
0.649 |
Apolipoprotein B, mg/dL |
120.1±32.0 |
87.2±22.2 |
0.003 |
Slit2, ng/mL |
1.855±1.306 |
2.352±1.864 |
0.103 |
Table 2Correlation Analysis between Slit2 Level and Metabolic Parameters
Variable |
Coefficient (r)a
|
P value |
BMI, kg/m2
|
0.143 |
0.144 |
Waist circumferences, cm |
0.265 |
0.103 |
Fasting glucose, mg/dL |
–0.246 |
0.008b
|
Fasting insulin, mIU/L |
0.055 |
0.572 |
Fasting C-peptide, mIU/L |
0.042 |
0.666 |
Postload 2-hour glucose, mg/dL |
–0.233 |
0.017c
|
Postload 2-hour insulin, mIU/L |
0.154 |
0.119 |
Postload 2-hour C-peptide, mIU/L |
0.110 |
0.275 |
HbA1c, % |
–0.357 |
<0.001b
|
HOMA-IR |
–0.136 |
0.157 |
HOMA-β |
0.203 |
0.033c
|
TG, mg/dL |
0.021 |
0.831 |
LDL-C, mg/dL |
–0.138 |
0.155 |
HDL-C, mg/dL |
–0.032 |
0.742 |
TC, mg/dL |
–0.170 |
0.078 |
hs-CRP, mg/dL |
–0.084 |
0.486 |