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Volume 24(4); December 2009
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Review Articles
Why to Keep Osteocytes Alive and How?.
Teresita Bellido
J Korean Endocr Soc. 2009;24(4):223-226.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.223
  • 1,506 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
It has been long proposed that the osteocyte network continually compares present mechanical strains to usual levels of strain, and triggers signals to osteoclasts or osteoblasts resulting in bone loss or gain, as needed. Whereas physiological levels of mechanical stimulation maintain bone mass, too low or too high levels of strain induce bone resorption. One mechanism by which osteocytes may trigger bone resorption is by undergoing apoptosis. Either low or high levels of mechanical loading lead to increased prevalence of osteocyte apoptosis, which temporally precedes and is spatially associated with osteoclast recruitment and the subsequent increase in bone resorption[1,2]. A cause and effect relationship between osteocyte death and bone resorption has been demonstrated using a transgenic mouse model of inducible osteocyte ablation in which osteocyte apoptosis was sufficient to trigger osteoclast recruitment[3]. In addition, the normal osteoclastogenic response to unloading was missing in bones from osteocyte-depleted mice, confirming that osteocytes are indispensable for the skeletal adaptation to weightlessness. Because osteocyte apoptosis is inhibited not only by mechanical stimulation but also by estrogens and bisphosphonates, these findings raise the intriguing possibility that preservation of osteocyte viability contributes to the anti-remodeling properties of these agents.

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  • Navicular syndrome in sport horses as a result of the disorder of biological bone tissue turnover rhythm: a review
    Marcin Komosa, Halina Purzyc, Monika Wojnar, Hieronim Frąckowiak, Franciszek Kobryńczuk
    Biological Rhythm Research.2013; 44(3): 339.     CrossRef
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Bisphosphonate Related Osteonecrosis of the Jaw (BRONJ): Position Statement of Korea.
J Korean Endocr Soc. 2009;24(4):227-230.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.227
  • 1,734 View
  • 36 Download
  • 8 Crossref
AbstractAbstract PDF
No abstract available.

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Citations to this article as recorded by  
  • 악골골수염 처치를 위한 조직공학적 접근
    Soung Min Kim, Kyung Mi Woo, Hoon Myoung, Jong Ho Lee, Suk Keun Lee
    Tissue Engineering and Regenerative Medicine.2015; 12(S1): 11.     CrossRef
  • Drug holiday as a prognostic factor of medication-related osteonecrosis of the jaw
    Yoon Ho Kim, Ho Kyung Lee, Seung Il Song, Jeong Keun Lee
    Journal of the Korean Association of Oral and Maxillofacial Surgeons.2014; 40(5): 206.     CrossRef
  • Comparative Study on Surgical and Conservative Management of Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) in Disease Stage 2
    Ho Kyung Lee, Mi Hyun Seo, Kang Mi Pang, Seung Il Song, Jeong Keun Lee
    The Journal Of Korean Association of Maxillofacial Plastic and Reconstructive Surgeons.2013; 35(5): 302.     CrossRef
  • Bisphosphonates-related osteonecrosis of the jaw in Korea: a preliminary report
    Jeong Keun Lee, Kyung-Wook Kim, Jin-Young Choi, Seong-Yong Moon, Su-Gwan Kim, Chul-Hwan Kim, Hyeon-Min Kim, Yong-Dae Kwon, Yong-Deok Kim, Dong-Keun Lee, Seung-Ki Min, In-Sook Park, Young-Wook Park, Min-Suk Kook, Hong-Ju Park, Jin-A Baek, Jun-Woo Park, Tae
    Journal of the Korean Association of Oral and Maxillofacial Surgeons.2013; 39(1): 9.     CrossRef
  • A Case of Sinusitis due to Bisphosphonate Related Osteonecrosis of Jaw
    Sung Do Jung, Hye Ran Son, Young Jun Chung, Ji Hun Mo
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2012; 55(9): 590.     CrossRef
  • Retrospective study on the bisphosphonate-related osteonecrosis of jaw
    Yoon-Sic Han, In-Woo Lee, Ho Lee, Jin-Won Suh, Soung-Min Kim, Hoon Myoung, Soon-Jung Hwang, Jin-Young Choi, Jong-Ho Lee, Pill-Hoon Choung, Myung-Jin Kim, Byoung-Moo Seo
    Journal of the Korean Association of Oral and Maxillofacial Surgeons.2011; 37(6): 470.     CrossRef
  • Consideration for treatment of bisphosphonate-related osteonecrosis of the jaw
    Kyung-Ha You, Kyu-Ho Yoon, Jung-Ho Bae, Jae-An Park, Gun-Chan Park, Jae-Myung Shin, Jee-Seon Baik, Jeong-Kwon Cheong
    Journal of the Korean Association of Oral and Maxillofacial Surgeons.2010; 36(3): 206.     CrossRef
  • Study on bisphosphonate-related osteonecrosis of the jaw (BRONJ): case report and literature review
    Yeo-Gab Kim, Baek-Soo Lee, Yong-Dae Kwon, Joon-Ho Suh, Sang-Mi Jeen
    Journal of the Korean Association of Oral and Maxillofacial Surgeons.2010; 36(4): 291.     CrossRef
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Pathological Mechanism of Glucocorticoid-induced Osteoporosis.
Hyun Ju Kim
J Korean Endocr Soc. 2009;24(4):231-236.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.231
  • 1,724 View
  • 19 Download
AbstractAbstract PDF
No abstract available.
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Editorial
Characteristics and Treatment Options of Pituitary Apoplexy.
Dong Sun Kim
J Korean Endocr Soc. 2009;24(4):237-239.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.237
  • 1,593 View
  • 17 Download
AbstractAbstract PDF
No abstract available.
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Original Articles
Clinico-pathologic Characteristics of the Primary Thyroid Cancer in Patients with Breast Cancer.
Hyun Won Shin, Hye Won Jang, Ji Young Park, Jae Hoon Chung, Young Ki Min, Myung Shik Lee, Moon Kyu Lee, Kwang Won Kim, Sun Wook Kim
J Korean Endocr Soc. 2009;24(4):240-246.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.240
  • 2,209 View
  • 27 Download
  • 3 Crossref
AbstractAbstract PDF
BACKGROUND
Both thyroid and breast cancers occur more frequently in women than in men. Some suggest that estrogen plays a role in the tumorigenesis of both cancers. The aim of this study was to identify the prevalence and clinico-pathologic characteristics of primary thyroid cancer in patients with breast cancer. METHODS: We retrospectively obtained clinical and pathologic data for 112 patients diagnosed with both thyroid and breast cancer from a single center. Patients with thyroid cancer were grouped according to the chronological sequence of tumor diagnosis. When thyroid and breast cancers were diagnosed within 12 months of each other, they were considered to have been diagnosed simultaneously. Female patients who had only papillary thyroid cancer were used as a historic control. RESULTS: Between 1994 and 2008, 7,827 patients at our hospital were diagnosed with breast cancer and 6,571 patients with thyroid cancer. There were 112 patients who had both thyroid and breast cancer. All thyroid cancers (111/112) except one hurthle cell cancer were papillary thyroid cancers. Average tumor size of thyroid cancer cases diagnosed 1) after or 2) simultaneously with the diagnosis of breast cancer was significantly lower than that for 3) thyroid cancer cases found before breast cancer diagnosis or 4) historical controls with papillary thyroid cancer [sizes (in cm), respectively, were: 1) 0.9 +/- 0.6 2) 0.9 +/- 0.5 vs 3) 1.4 +/- 0.9 4) 1.4 +/- 1.1, P < 0.05]. No patients had distant metastases and there were no statistically significant differences in known risk factors for recurrence and survival of patients with thyroid cancer. CONCLUSION: Thyroid cancer is the most common second primary malignancy in patients with breast cancer and most of them are papillary thyroid cancers. There are no differences in risk factors for tumor recurrence and patient survival compared with those with conventional papillary thyroid cancer except for differences in tumor size. These difference in size may reflect an increase in medical surveillance in patients after they are diagnosed with breast cancer.

Citations

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  • Survival Outcomes in Thyroid Cancer Patients with Co-Occurring Breast Cancer: Evidence of Mortality Risk Attenuation
    Matheus Wohlfahrt Baumgarten, Iuri Martin Goemann, Rafael Selbach Scheffel, Ana Luiza Maia
    Clinical Breast Cancer.2024;[Epub]     CrossRef
  • The prognosis and treatment of primary thyroid cancer occurred in breast cancer patients: comparison with ordinary thyroid cancer
    Chang Min Park, Young Don Lee, Eun Mee Oh, Kwan-Il Kim, Heung Kyu Park, Kwang-Pil Ko, Yoo Seung Chung
    Annals of Surgical Treatment and Research.2014; 86(4): 169.     CrossRef
  • Thyroid Metastasis from Breast Carcinoma Accompanied by Papillary Thyroid Carcinoma
    Song-I Yang, Kwang-Kuk Park, Jeong-Hoon Kim
    Case Reports in Oncology.2014; 7(2): 528.     CrossRef
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Pituitary Apoplexy in Korea - Characteristics, Treatment Options and Outcomes.
Jung Ah Lim, Jin Taek Kim, Min Joo Kim, Tae Hyuk Kim, Yenna Lee, Hwa Young Cho, Chan Soo Shin, Kyong Soo Park, Hak Chul Jang, Bo Youn Cho, Hong Kyu Lee, Seong Yeon Kim
J Korean Endocr Soc. 2009;24(4):247-253.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.247
  • 2,232 View
  • 23 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
Reports on pituitary apoplexy in Korea are limited. There are two treatment options for pituitary apoplexy - surgical decompression and conservative management. In this study, we examined clinical presentation and outcomes following different therapies in Korean patients with pituitary apoplexy. METHODS: Clinical data and treatment outcomes from 52 patients with pituitary apoplexy who visited Seoul National University Hospital between January 1992 and June 2008 were reviewed retrospectively. Patients were divided into 2 groups according to management options (a surgery group vs. a conservative management group) and their outcomes were compared. For patients who underwent surgery due to neurological symptoms, outcomes were compared between early and late surgery groups. RESULTS: Headache (73.1%) was the most common presenting symptom, and more than half of the patients were reported to have visual symptoms. The most common type of pathology was a nonfunctioning pituitary adenoma (67.3%). Nine patients received conservative management and 43 underwent surgical decompression. Their recovery from neurological and endocrinological abnormalities were similar. Among patients who showed neurological symptoms, 9 underwent surgery within 1 week of symptom onset and 24 underwent surgery after 1 week. There was no significant difference between outcomes of early and late surgery groups except recovery from impaired visual deficit was greater in the late surgery group. CONCLUSION: Patients with pituitary apoplexy in Korea show similar clinical features as similar patients in other countries. In our study, there was no significant difference between clinical outcomes of the surgery group and the conservative treatment group.

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  • The Outcomes of Pituitary Apoplexy with Conservative Treatment: Experiences at a Single Institution
    Youngbeom Seo, Yong Hwy Kim, Yun-Sik Dho, Jung Hee Kim, Jin Wook Kim, Chul-Kee Park, Dong Gyu Kim
    World Neurosurgery.2018; 115: e703.     CrossRef
  • Characteristics and Treatment Options of Pituitary Apoplexy
    Dong-Sun Kim
    Journal of Korean Endocrine Society.2009; 24(4): 237.     CrossRef
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Comparing the Prevalence of Primary Aldosteronism in Hypertensive Diabetic and Non-diabetic Patients.
Yi Sun Jang, Koon Soon Kim, Hye Soo Kim
J Korean Endocr Soc. 2009;24(4):254-259.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.254
  • 1,718 View
  • 20 Download
AbstractAbstract PDF
BACKGROUND
Primary aldosteronism is the most common cause of secondary hypertension in humans. Its prevalence is estimated to be 10-15% among hypertensive patients. It is also associated with insulin resistance and diabetes mellitus. The aim of our study was to compare the prevalence of primary aldosteronism in hypertensive patients with presence of diabetes mellitus. METHODS: We reviewed retrospectively the clinical records of 104 hypertensive patients for whom we also measured plasma renin activity (PRA) and plasma aldosterone concentrations (PAC). RESULTS: Among 104 hypertensive patients, 44 had diabetes and 60 did not. There were no significant differences in clinical characteristics between non-diabetic and diabetic patients except for age and the number of antihypertensive agents. Patients with target organ damage were more common among diabetic patients. There was no correlation between PAC and the number of target organs damaged. In addition, Four patients from the non-diabetic and two from the diabetic group had a ratio over 30 for PRA/PAC and a PAC of over 15 ng/dL. Two non-diabetic patients and one diabetic patient were found, on abdomen CT, to have an adrenal adenoma. The rest of the patients refused further tests. CONCLUSION: The prevalence of primary aldosteronism in diabetic patients does not differ significantly from that in non-diabetic patients. Therefore, the present routine screening test for primary aldosteronism in hypertensive diabetic patients is not recommended.
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Case Reports
A Case of Recurrent Ectopic Parathyroid Adenoma Developed 22 Years after the Initial Parathyroidectomy.
Yoon Jung Kim, Ji A Seo, Ji Mi Moon, Young Jin Seo, Hae Yoon Choi, Hye Sook Kim, Sin Gon Kim, Kyeung mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim
J Korean Endocr Soc. 2009;24(4):260-264.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.260
  • 2,048 View
  • 27 Download
AbstractAbstract PDF
Persistent or recurrent primary hyperparathyroidism after initial parathyroid surgery occurs at rates of 1.5~10%. A single missed parathyroid adenoma accounts for the majority of persistent hyperparathyroidism, whereas metachronous parathyroid adenoma is a rare cause of recurrent hypercalcemia. We report a case of a 39-year-old female who presented with recurrent pancreatitis. She had symptoms of hyperparathyroidism such as hypercalcemia, hypophosphatemia, hypercalciuria, nephrocalcinosis, and osteoporosis. She had a 2-cm firm neck mass under the right submandibular area. She was diagnosed with primary hyperparathyroidism 22 years ago. At that time, the right upper and lower parathyroid glands were removed after exploration of all parathyroid glands, and a right upper parathyroid adenoma was diagnosed. Now, she had a second surgery to remove the right submandibular mass with intraoperative PTH monitoring, which was diagnosed as a parathyroid adenoma in an ectopic supernumerary parathyroid gland. Because of hungry bone syndrome, she received calcium carbonate replacement therapy and has no evidence of recurrence. Here, we report a recurrent parathyroid adenoma in the undescended, supernumerary parathyroid gland after a long interval from the initial surgery.
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Ectopic ACTH Syndrome with Bilateral Pheochromocytoma in Multiple Endocrine Neoplasia Type 2A.
Ji Mi Moon, Yoon Jung Kim, Young Jin Seo, Hye Yoon Choi, Joo Hyong Kim, Ju Ri Park, Yun Jeong Lee, Hee Young Kim, Sin Gon Kim, Dong Seop Choi
J Korean Endocr Soc. 2009;24(4):265-271.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.265
  • 2,202 View
  • 30 Download
  • 4 Crossref
AbstractAbstract PDF
Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant syndrome characterized by the presence of medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism. MEN 2A arises due to a germline missense mutation of the RET proto-oncogene. Specific RET mutation analysis has revolutionized the diagnosis and therapy of this disorder, and early thyroidectomy may have lowered the morbidity and mortality associated with these diseases. Ectopic adrenocorticotropic hormone (ACTH) syndrome is characterized by hypercortisolism due to the hypersecretion of ACTH outside of the pituitary gland; the most common causes are malignancies, but rarely adrenal pheochromocytoma may be the cause.

Citations

Citations to this article as recorded by  
  • Pheochromocytoma With High Adrenocorticotropic Hormone Production Capacity Without Pigmentation and Cushingoid Symptoms: A Case Report With a Literature Review
    Gen Mizutani, Masashi Isshiki, Eisuke Shimizu, Daigo Saito, Akira Shimada
    Cureus.2024;[Epub]     CrossRef
  • Ectopic ACTH- and/or CRH-Producing Pheochromocytomas
    Patrick F Elliott, Thomas Berhane, Oskar Ragnarsson, Henrik Falhammar
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(2): 598.     CrossRef
  • Severe Cushing Syndrome Due to an ACTH-Producing Pheochromocytoma: A Case Presentation and Review of the Literature
    Jenan N Gabi, Maali M Milhem, Yara E Tovar, Emhemmid S Karem, Alaa Y Gabi, Rodhan A Khthir
    Journal of the Endocrine Society.2018; 2(7): 621.     CrossRef
  • Adrenocorticotropic hormone (ACTH)-producing pheochromocytoma presented as Cushing syndrome and complicated by invasive aspergillosis
    Jae Ho Cho, Da Eun Jeong, Jae Young Lee, Jong Geol Jang, Jun Sung Moon, Mi Jin Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Yeungnam University Journal of Medicine.2015; 32(2): 132.     CrossRef
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A Case of Graves' Disease with Pancytopenia.
Jong Ho Shin, Hyun Jin Kim, Si Bum Kim, Dong Pil Kim, Bong Suk Ko, Dong Soon Kim, Ji Myung Kim, Soo Jung Gong, Jung Ae Lee
J Korean Endocr Soc. 2009;24(4):272-276.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.272
  • 2,074 View
  • 28 Download
  • 3 Crossref
AbstractAbstract PDF
Hematological disorders, and especially single lineage abnormalities, have been described in patients suffering with thyrotoxicosis, but pancytopenia is a rare complication of thyrotoxicosis. Pancytopenia with thyrotoxicosis has been reported to be totally reversible with antithyroid drug treatment. We experienced a case with pancytopenia associated with Graves' disease in a 57-year-old woman who had no specific cause of pancytopenia. She presented with dyspnea and palpitation. The laboratory findings revealed thyrotoxicosis and pancytopenia. Increased radioisotope uptake was seen on the thyroid scan and normal cellularity and maturation were found in the bone marrow aspiration biopsy. Based on these findings, she was diagnosed as suffering from Gravesyendisease with pancytopenia. After treatment with propylthiouracil, the blood cell counts were restored to normal as the patient achieved a euthyroid state. We report here on a case of Graves' disease that was complicated by pancytopenia, and all this was normalized after treatment for hyperthyroidism.

Citations

Citations to this article as recorded by  
  • Non-myeloproliferative Pancytopenia: A Rare Presentation of Thyrotoxicosis
    Izzathunnisa Rahmathullah, Maheswaran Umakanth, Suranga Singhapathirane
    Cureus.2023;[Epub]     CrossRef
  • Pancytopenia in a surgical patient, a rare presentation of hyperthyroidism
    Prabhat Jha, Yogendra Prasad Singh, Bikal Ghimire, Binit Kumar Jha
    BMC Surgery.2014;[Epub]     CrossRef
  • A Case of Pancytopenia with Hyperthyroidism
    Tae Hoon Kim, Ji Sung Yoon, Byung Sam Park, Dong Won Lee, Jae Ho Cho, Jun Sung Moon, Eui Hyun Kim, Kyu Chang Won, Hyoung Woo Lee
    Yeungnam University Journal of Medicine.2013; 30(1): 47.     CrossRef
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A Case of Prolonged Hypoglycemia Post Topiramate Treatment an Anti-convulsant, in a Type 2 Diabetic Patient.
Myung Jun Lee, Yoon Shick Yom, Hyun woo Lim, Sung Tae Kim, Yu Mi Lee, Youn Zoo Cho, Kang Woo Lee, Byung Joon Kim, Keun Young Park, Dong Mee Lim
J Korean Endocr Soc. 2009;24(4):277-280.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.277
  • 3,942 View
  • 101 Download
AbstractAbstract PDF
Topiramate is a drug used to treat epilepsy, and is known for its effects including reduced appetite resulting in lower body weight, and the lowering of neutral fat. In addition, topiramate is known to reduce blood sugar levels by increasing insulin sensitivity and by increasing insulin secretion by glucose stimulation. The authors report a case of persistent hypoglycemia, in a patient who had been administrating topiramate, as a treatment for epilepsy following an episode of cerebral infarction.
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A Case of Insulin Autoimmune Syndrome in a Patient with Partial Hypopituitarism.
Obin Kwon, Eun Young Park, Jin Young Yoon, Kwang Joon Kim, Yong ho Lee, Jae Won Hong, Eun Jig Lee, Sung Kil Lim, Hyun Chul Lee, Bong Soo Cha
J Korean Endocr Soc. 2009;24(4):281-286.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.281
  • 1,782 View
  • 23 Download
AbstractAbstract PDF
Insulin autoimmune syndrome is one of the rare causes of hypoglycemia, and characterized by hyperinsulinemic hypoglycemia associated with high titer of antibodies to endogenous insulin. We report a case of insulin autoimmune syndrome in a 57-year-old woman, presenting with mental changes due to hypoglycemia. She had no history of diabetes or insulin administration. The serum C-peptide level was 4.69 ng/mL and the insulin concentration was 229.55 microU/mL, when fasting plasma glucose level was 32 mg/dL. The insulin-to-glucose ratio was 7.17, while there was no radiologic evidence of insulinoma. The insulin antibody level was over 100 microU/mL, resulting in the diagnosis of insulin autoimmune syndrome. Hormonal studies revealed partial hypopituitarism and a lack of glucagon-response to hypoglycemia. Hypoglycemia disappeared with replacement of prednisolone with levothyroxine therapy. Under secretion of growth hormone and of adrenocorticotropic hormone due to hypopituitarism were associated with insufficient counterregulation to hypoglycemia. One should keep in mind that insulin autoimmune syndrome or hypopituitarism is one cause of hypoglycemia in patients with no history of diabetes, and corticosteroid can be an effective treatment for both diseases.
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A Case of Hashimoto's Thyroiditis Accompanied by Autoimmune Hepatitis Diagnosed with Liver Biopsy.
Young Jun Lee, Ji Yoon Sung, Sei Hyun Kim, Hyon Seung Yi, Yun Soo Kim, Sihoon Lee, Ie Byung Park
J Korean Endocr Soc. 2009;24(4):287-292.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.287
  • 1,957 View
  • 23 Download
  • 2 Crossref
AbstractAbstract PDF
Autoimmune thyroid diseases, including Hashimoto's thyroiditis (HT), are common organ-specific autoimmune disorders that often occur in conjunction with other autoimmune diseases. Autoimmune hepatitis (AIH) is a relatively rare disease of unknown etiology. In this condition, progressive destruction of the liver parenchyma occurs. Without proper treatment with immunosuppressive agents, such as prednisone and azathioprine, this condition leads to cirrhosis and liver failure. Timely detection and appropriate treatment of the AIH is prerequisite for the long-term survival of affected patients. We report here a case of HT accompanied by AIH confirmed by liver biopsy. On the basis of this case report, we suggest that, a sustained elevation of aminotransferases refractory to thyroid dysfunction correction should result in a liver biopsy to differentiate AIH from other forms of liver dysfunction or secondary to thyroid disorders. Treatment should commence promptly.

Citations

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  • Autoimmune Hashimoto thyroiditis with concomitant autoimmune hepatitis
    Nevena Manevska, Natasa Stojkovska, Ljubica Tasheva, Marija Jovanovski-Srceva, Tanja Makazlieva, Sinisha Stojanoski
    Archives of Public Health.2022;[Epub]     CrossRef
  • A Case of Demyelinating Peripheral Neuropathy Associated with Hashimoto`s Thyroiditis
    Jung Hwan Park M.D., Sang Mo Hong M.D., Chang Bum Lee M.D., Yong Soo Park M.D., Dong Sun Kim M.D., Woong Hwan Choi M.D., You Hern Ahn M.D.
    Journal of the Korean Geriatrics Society.2011; 15(4): 234.     CrossRef
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A Case of Sporadic Medullary Thyroid Cancer with RET G691S Polymorphism.
Min Kyu Kang, Jung Min Lee, Ji Hyun Kim, Min Young Lee, Ji Hyun Kim, Sung Dae Moon, Je Ho Han, Sang Ah Chang
J Korean Endocr Soc. 2009;24(4):293-297.   Published online December 1, 2009
DOI: https://doi.org/10.3803/jkes.2009.24.4.293
  • 1,905 View
  • 25 Download
AbstractAbstract PDF
Sporadic medullary thyroid carcinoma (MTC) is the most common form of MTC and somatic RET proto-oncogene mutations account for approximately 25% of the patients with sporadic MTC. However, other pathogeneses of sporadic MTC are still unclear. Not only RET mutation, but also polymorphisms of RET may have an association with sporadic MTC. We herein describe the association of MTC and RET proto-oncogene polymorphism. A 51-year-old man was diagnosed with MTC, which was incidentally found on a thyroid sonogram. The patient underwent total thyroidectomy and genetic mutational analysis of the RET gene. Genetic testing detected a polymorphism in codon 691 (G691S) on exon 11 of the RET proto-oncogene. His son and daughter had the same polymorphism. We report on this case along with a review of the related literature on RET gene polymorphism of sporadic MTC.
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