Brief Report
- Diabetes, obesity and metabolism
- Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice
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Jooyeop Lee, Min Joo Kim, Seoil Moon, Ji Yoon Lim, Kyong Soo Park, Hye Seung Jung
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Endocrinol Metab. 2023;38(6):782-787. Published online November 13, 2023
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DOI: https://doi.org/10.3803/EnM.2023.1738
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Abstract
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- Although pancreatic endoplasmic reticulum kinase (PERK) is indispensable to beta cells, low-dose PERK inhibitor improved glucose- stimulated insulin secretion (GSIS) and hyperglycemia in diabetic mice. Current study examined if partial deletion of Perk (Perk+/-) recapitulated the effects of PERK inhibitor, on the contrary to the complete deletion. Perk+/- mice and wild-type controls were fed with a high-fat diet (HFD) for 23 weeks. Glucose tolerance was evaluated along with serum insulin levels and islet morphology. Perk+/- mice on normal chow were comparable to wild-type mice in various metabolic features. HFD-induced obesity was not influenced by Perk reduction; however, HFD-induced glucose intolerance was significantly improved since 15-week HFD. HFD-induced compromises in GSIS were relieved by Perk reduction, accompanied by reductions in phosphorylated PERK and activating transcription factor 4 (ATF4) in the islets. Meanwhile, HFD-induced islet expansion was not significantly affected. In summary, partial deletion of Perk improved glucose tolerance and GSIS impaired by diet-induced obesity, without changes in body weights or islet mass.
Review Article
- Miscellaneous
- Brown Adipose Tissue: Activation and Metabolism in Humans
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Imane Hachemi, Mueez U-Din
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Endocrinol Metab. 2023;38(2):214-222. Published online March 27, 2023
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DOI: https://doi.org/10.3803/EnM.2023.1659
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- Brown adipose tissue (BAT) is a thermogenic organ contributing to non-shivering thermogenesis. BAT becomes active under cold stress via sympathetic nervous system activation. However, recent evidence has suggested that BAT may also be active at thermoneutrality and in a postprandial state. BAT has superior energy dissipation capacity compared to white adipose tissue (WAT) and muscles. Thus, it has been proposed that the recruitment and activation of additional BAT may increase the overall energy-expending capacity in humans, potentially improving current whole-body weight management strategies. Nutrition plays a central role in obesity and weight management. Thus, this review discusses human studies describing BAT hyper-metabolism after dietary interventions. Nutritional agents that can potentially recruit brown adipocytes via the process of BAT-WAT transdifferentiation are also discussed.
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- Spermidine activates adipose tissue thermogenesis through autophagy and fibroblast growth factor 21
Yinhua Ni, Liujie Zheng, Liqian Zhang, Jiamin Li, Yuxiang Pan, Haimei Du, Zhaorong Wang, Zhengwei Fu
The Journal of Nutritional Biochemistry.2024; 125: 109569. CrossRef - A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance and endurance performance: a randomized, double-blind, placebo-controlled study
N. Roopashree, Das S. Syam, I. M. Krishnakumar, K. N. Mala, Bradley S. Fleenor, Jestin Thomas
Frontiers in Nutrition.2024;[Epub] CrossRef - MRI Methods to Visualize and Quantify Adipose Tissue in Health and Disease
Katerina Nikiforaki, Kostas Marias
Biomedicines.2023; 11(12): 3179. CrossRef
Original Articles
- Calcium & Bone Metabolism
- Effect of Vitamin D Supplementation on Risk of Fractures and Falls According to Dosage and Interval: A Meta-Analysis
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Sung Hye Kong, Han Na Jang, Jung Hee Kim, Sang Wan Kim, Chan Soo Shin
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Endocrinol Metab. 2022;37(2):344-358. Published online April 25, 2022
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DOI: https://doi.org/10.3803/EnM.2021.1374
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Abstract
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- Background
Although recent studies comparing various dosages and intervals of vitamin D supplementation have been published, it is yet to be elucidated whether there is an appropriate dose or interval to provide benefit regarding fracture risk. We aimed to assess the published evidence available to date regarding the putative beneficial effects of vitamin D supplements on fractures and falls according to various dosages and intervals.
Methods
We performed a meta-analysis of randomized controlled studies reporting associations between vitamin D supplementation and the risks of fractures and falls in PubMed, EMBASE, and Cochrane library. Studies with supplements of ergocalciferol or calcitriol, those with a number of event ≤10, or those with a follow-up duration of less than 6 months were also excluded.
Results
Thirty-two studies were included in the final analysis. Vitamin D supplementation with daily dose of 800 to 1,000 mg was associated with lower risks of osteoporotic fracture and fall (pooled relative risk [RR], 0.87; 95% confidence interval [CI], 0.78 to 0.97 and RR, 0.91; 95% CI, 0.85 to 0.98), while studies with <800 or >1,000 mg/day did not. Also, among intervals, daily administration of vitamin D was associated with the reduced risk of falls, while intermittent dose was not. Also, patients with vitamin D deficiency showed a significant risk reduction of falls after vitamin D supplementation.
Conclusion
Daily vitamin D dose of 800 to 1,000 IU was the most probable way to reduce the fracture and fall risk. Further studies designed with various regimens and targeted vitamin D levels are required to elucidate the benefits of vitamin D supplements.
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Citations
Citations to this article as recorded by
- Ukrainian Consensus on Diagnosis and Management of Vitamin D Deficiency in Adults
Nataliia Grygorieva, Mykola Tronko, Volodymir Kovalenko, Serhiy Komisarenko, Tetiana Tatarchuk, Ninel Dedukh, Mykola Veliky, Serhiy Strafun, Yulia Komisarenko, Andrii Kalashnikov, Valeria Orlenko, Volodymyr Pankiv, Oleg Shvets, Inna Gogunska, Svitlana Reg
Nutrients.2024; 16(2): 270. CrossRef - Vitamin D Supplementation: A Review of the Evidence Arguing for a Daily Dose of 2000 International Units (50 µg) of Vitamin D for Adults in the General Population
Pawel Pludowski, William B. Grant, Spyridon N. Karras, Armin Zittermann, Stefan Pilz
Nutrients.2024; 16(3): 391. CrossRef - Clinical Characteristics and Outcomes of Limb Fractures in Saudi Children
Lamia Aldhbiban, Fai Alhoshan, Raghad Alomari, Shahad A Almatrafi, Yousef Alanazi, Samir Alsayegh, Haifa Y Alfaraidi, Ayman H Jawadi, Fahad N Aljuraibah
Cureus.2024;[Epub] CrossRef - The interplay of rheumatoid arthritis and osteoporosis: exploring the pathogenesis and pharmacological approaches
Nikhil Gupta, Navjot Kanwar, Anchal Arora, Kavin Khatri, Abhinav Kanwal
Clinical Rheumatology.2024; 43(5): 1421. CrossRef - The multi-faceted nature of age-associated osteoporosis
A.E. Smit, O.C. Meijer, E.M. Winter
Bone Reports.2024; 20: 101750. CrossRef - Vitamin D Deficiency in Patients With Low-Energy Hip Fractures in Accordance With the Mediterranean Paradox
Christos Konstantinidis, Ourania Psoma, Christos Kotsias, Vasileios Panagiotopoulos , Sotiris Plakoutsis, Dimitrios Tsiampas, Dimitrios Vardakas, Dimitrios Giotis
Cureus.2024;[Epub] CrossRef - Association of vitamin and/or nutritional supplements with fall among patients with diabetes: A prospective study based on ACCORD and UK Biobank
Lingfang He, Tianqi Ma, Guogang Zhang, Xunjie Cheng, Yongping Bai
Frontiers in Nutrition.2023;[Epub] CrossRef - Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs
Gavriela Voulgaridou, Sousana K. Papadopoulou, Paraskevi Detopoulou, Despoina Tsoumana, Constantinos Giaginis, Foivi S. Kondyli, Evgenia Lymperaki, Agathi Pritsa
Diseases.2023; 11(1): 29. CrossRef - Recent advances in the identification of related factors and preventive strategies of hip fracture
Yaohui Yu, Yudan Wang, Xiaoli Hou, Faming Tian
Frontiers in Public Health.2023;[Epub] CrossRef - Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?
Sadao Yoshida, Ryo Shiraishi, Yuki Nakayama, Yasuko Taira
Nutrients.2023; 15(13): 2991. CrossRef - Safety Profile of Vitamin D in Italy: An Analysis of Spontaneous Reports of Adverse Reactions Related to Drugs and Food Supplements
Valentina Maggini, Giada Crescioli, Ilaria Ippoliti, Eugenia Gallo, Francesca Menniti-Ippolito, Adelaide Chiaravalloti, Vittorio Mascherini, Roberto Da Cas, Simona Potenza, Giulia Gritti, Maria Galiulo, Laura Sottosanti, Alfredo Vannacci, Niccolò Lombardi
Journal of Clinical Medicine.2023; 12(14): 4726. CrossRef - Cholecalciferol Use Is Associated With a Decreased Risk of Incident Morphometric Vertebral Fractures in Acromegaly
Sabrina Chiloiro, Stefano Frara, Irene Gagliardi, Antonio Bianchi, Antonella Giampietro, Margherita Medici, Agnese Allora, Luigi di Filippo, Maria Rosaria Ambrosio, Alfredo Pontecorvi, Maria Chiara Zatelli, Laura De Marinis, Andrea Giustina
The Journal of Clinical Endocrinology & Metabolism.2023; 109(1): e58. CrossRef - Proceedings of the 2023 Santa Fe Bone Symposium: Progress and Controversies in the Management of Patients with Skeletal Diseases
E. Michael Lewiecki, Teresita Bellido, John P. Bilezikian, Jacques P. Brown, Azeez Farooki, Christopher S. Kovacs, Brendan Lee, William D. Leslie, Michael R. McClung, Mark L. Prasarn, Deborah E. Sellmeyer
Journal of Clinical Densitometry.2023; 26(4): 101432. CrossRef - Diagnosis, prevention and treatment of vitamin D deficiency in adults: Ukrainian experts consensus statement
N.V. Grygorieva, M.D. Tronko, V.M. Kovalenko, S.V. Komisarenko, T.F. Tatarchuk, N.V. Dedukh, M.M. Veliky, S.S. Strafun, Y.I. Komisarenko, A.V. Kalashnikov, V.L. Orlenko, V.I. Pankiv, O.V. Shvets, I.V. Gogunska, S.I. Regeda
PAIN, JOINTS, SPINE.2023; 13(2): 60. CrossRef - Serum 25-Hydroxyvitamin D Level Is Negatively Associated with Fatigue in Elderly Maintenance Hemodialysis Patients
Menglin Pang, Lin Chen, Na Jiang, Mengmeng Jiang, Baofeng Wang, Lili Wang, Xiao-yan Jia
Kidney and Blood Pressure Research.2023; 48(1): 231. CrossRef - Vitamin D for Clinical Diseases in Women: An Indispensable Factor in Medicine and Dentistry
Dario Calafiore, Leonzio Fortunato, Mario Migliario
Journal of Clinical Medicine.2022; 11(11): 3104. CrossRef - Malnutrition in Older Adults—Effect on Falls and Fractures: A Narrative Review
Malgorzata Kupisz-Urbanska, Ewa Marcinowska-Suchowierska
Nutrients.2022; 14(15): 3123. CrossRef - Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group
Thierry Chevalley, Maria Luisa Brandi, Kevin D. Cashman, Etienne Cavalier, Nicholas C. Harvey, Stefania Maggi, Cyrus Cooper, Nasser Al-Daghri, Oliver Bock, Olivier Bruyère, Mario Miguel Rosa, Bernard Cortet, Alfonso J. Cruz-Jentoft, Antonio Cherubini, Bes
Aging Clinical and Experimental Research.2022; 34(11): 2603. CrossRef - The Relationship of Osteoporosis with Menopause: Review of Article
Hadeel Anwar Alsarraje, *Liqaa Khalel Alhyali
International Journal of Research in Medical Sciences and Technology.2022; 14(01): 127. CrossRef
- Thyroid
- Evaluation of Iodine Status among Korean Patients with Papillary Thyroid Cancer Using Dietary and Urinary Iodine
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Ji Yeon Choi, Joon-Hyop Lee, YoonJu Song
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Endocrinol Metab. 2021;36(3):607-618. Published online June 21, 2021
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DOI: https://doi.org/10.3803/EnM.2021.1005
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- Background
Concerns have been raised regarding thyroid disorders caused by excessive iodine in Koreans, who have iodine-rich diets. This study evaluated iodine status using dietary iodine intake and urinary iodine in papillary thyroid cancer (PTC) patients.
Methods
Dietary data of PTC patients were assessed using a 24-hour recall and food frequency questionnaire (FFQ), and urinary iodine concentrations (UICs) were also obtained. To compare the iodine status of PTC patients, Korean adults with or without thyroid disease from the Korea National Health and Nutrition Examination Survey, which had 24-hour recall data and urinary iodine measurements, were analyzed.
Results
The median daily iodine intake by 24-hour recall was 341.7 μg/day in PTC patients, similar to the levels of other Korean adults. Based on UICs, the prevalence of excessive iodine was 54.4% in PTC patients, which was similar to the prevalence among subjects with thyroid disease (55.4%) but slightly higher than that in subjects without thyroid disease (47.7%). Based on dietary iodine by 24-hour recall, the prevalence of excessive iodine intake was 7.2%, which was higher than that among subjects with (4.4%) or without (3.9%) thyroid disease. The dietary iodine intake based on 24-hour recall was closely correlated with the UIC (r=0.4826) in PTC patients, but dietary iodine by FFQ was not significantly correlated with either 24-hour recall or UIC-based dietary iodine.
Conclusion
Excessive iodine intake was more common in PTC patients than in subjects without thyroid disease. Further longitudinal research is necessary to elucidate the role of dietary iodine in PTC.
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Citations
Citations to this article as recorded by
- Association between iodine nutrition and cervical lymph node metastasis of papillary thyroid microcarcinoma
Hengqiang Zhao, Jin Hu, Le Cui, Yiping Gong, Tao Huang
Frontiers in Endocrinology.2023;[Epub] CrossRef - Effect of iodine restriction on short-term changes in thyroid function in patients with subclinical hypothyroidism
Obin Kwon, Dong Yeob Shin, Eun Jig Lee
Journal of Nutrition and Health.2022; 55(2): 250. CrossRef - Iodine nutrition and papillary thyroid cancer
Xueqi Zhang, Fan Zhang, Qiuxian Li, Chuyao Feng, Weiping Teng
Frontiers in Nutrition.2022;[Epub] CrossRef
- Endocrine Research
- DEHP Down-Regulates Tshr Gene Expression in Rat Thyroid Tissues and FRTL-5 Rat Thyrocytes: A Potential Mechanism of Thyroid Disruption
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Min Joo Kim, Hwan Hee Kim, Young Shin Song, Ok-Hee Kim, Kyungho Choi, Sujin Kim, Byung-Chul Oh, Young Joo Park
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Endocrinol Metab. 2021;36(2):447-454. Published online March 31, 2021
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DOI: https://doi.org/10.3803/EnM.2020.920
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5,074
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Abstract
PDFSupplementary MaterialPubReader ePub
- Background
Di-2-ethylhexyl phthalate (DEHP) is known to disrupt thyroid hormonal status. However, the underlying molecular mechanism of this disruption is unclear. Therefore, we investigated the direct effects of DEHP on the thyroid gland.
Methods
DEHP (vehicle, 50 mg/kg, and 500 mg/kg) was administered to Sprague-Dawley rats for 2 weeks. The expression of the thyroid hormone synthesis pathway in rat thyroid tissues was analyzed through RNA sequencing analysis, quantitative reverse transcription-polymerase chain reaction (RT-PCR), and immunohistochemical (IHC) staining. DEHP was treated to FRTL-5 rat thyroid cells, and an RT-PCR analysis was performed. A reporter gene assay containing the promoter of thyroid stimulating hormone receptor (TSHR) in Nthy-ori 3-1 human thyroid cells was constructed, and luciferase activity was determined.
Results
After DEHP treatment, the free thyroxine (T4) and total T4 levels in rats significantly decreased. RNA sequencing analysis of rat thyroid tissues showed little difference between vehicle and DEHP groups. In the RT-PCR analysis, Tshr expression was significantly lower in both DEHP groups (50 and 500 mg/kg) compared to that in the vehicle group, and IHC staining showed that TSHR expression in the 50 mg/kg DEHP group significantly decreased. DEHP treatment to FRTL-5 cells significantly down-regulated Tshr expression. DEHP treatment also reduced luciferase activity in a reporter gene assay for TSHR.
Conclusion
Although overall genetic changes in the thyroid hormone synthesis pathway are not clear, DEHP exposure could significantly down-regulate Tshr expression in thyroid glands. Down-regulation of Tshr gene appears to be one of potential mechanisms of thyroid disruption by DEHP exposure.
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Citations
Citations to this article as recorded by
- ARTS is essential for di-2-ethylhexyl phthalate (DEHP)-induced apoptosis of mouse Leydig cells
Yue Li, Linlin Xu, Chaoju Hao, Si Yang, Jinglei Wang, Jiaxiang Chen
Ecotoxicology and Environmental Safety.2024; 270: 115882. CrossRef - Thyroid dysfunction caused by exposure to environmental endocrine disruptors and the underlying mechanism: A review
Jie He, Jie Xu, Mucong Zheng, Kai Pan, Lilin Yang, Lina Ma, Chuyang Wang, Jie Yu
Chemico-Biological Interactions.2024; 391: 110909. CrossRef - Intrauterine exposure to di(2-ethylhexyl) phthalate (DEHP) disrupts the function of the hypothalamus-pituitary-thyroid axis of the F1 rats during adult life
Érica Kássia Sousa-Vidal, Guilherme Henrique, Renata Elen Costa da Silva, Caroline Serrano-Nascimento
Frontiers in Endocrinology.2023;[Epub] CrossRef - Drinking water disinfection byproduct iodoacetic acid affects thyroid hormone synthesis in Nthy-ori 3–1 cells
Jingyi Xiao, Yujie Sha, Yuwen Huang, Kunling Long, Huan Wu, Yan Mo, Qiyuan Yang, Shengkun Dong, Qiang Zeng, Xiao Wei
Ecotoxicology and Environmental Safety.2023; 257: 114926. CrossRef - Assessment of five typical environmental endocrine disruptors and thyroid cancer risk: a meta-analysis
Yuyao Yang, Xiaoyue Bai, Juan Lu, Ronghao Zou, Rui Ding, Xiaohui Hua
Frontiers in Endocrinology.2023;[Epub] CrossRef - Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq
Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Frontiers in Endocrinology.2023;[Epub] CrossRef - Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications
Xueting Zhang, Wen Qi, Qi Xu, Xu Li, Liting Zhou, Lin Ye
Environmental Science and Pollution Research.2022; 29(2): 1634. CrossRef - The possible thyroid disruptive effect of di-(2-ethyl hexyl) phthalate and the potential protective role of selenium and curcumin nanoparticles: a toxicological and histological study
Naima Abd El-Halim Sherif, Asmaa El-Banna, Rehab Ahmed Abdel-Moneim, Zahraa Khalifa Sobh, Manal Ibrahim Fathy Balah
Toxicology Research.2022; 11(1): 108. CrossRef - Environmental disruption of reproductive rhythms
Marie-Azélie Moralia, Clarisse Quignon, Marine Simonneaux, Valérie Simonneaux
Frontiers in Neuroendocrinology.2022; 66: 100990. CrossRef - Endocrine-disruptor endpoints in the ovary and thyroid of adult female rats exposed to realistic doses of di-(2-ethylhexyl) phthalate
Amel Jebara, Asma Beltifa, Guissepa Di Bella, Lotfi Mabrouk, Hedi Ben Mansour
Journal of Water and Health.2022; 20(8): 1256. CrossRef - The influence of sunitinib and sorafenib, two tyrosine kinase inhibitors, on development and thyroid system in zebrafish larvae
Gang Wei, Cao-xu Zhang, Yu Jing, Xia Chen, Huai-dong Song, Liu Yang
Chemosphere.2022; 308: 136354. CrossRef - Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: An in vitro mechanistic investigation
Qi Xu, Liting Zhou, Hyonju Ri, Xu Li, Xueting Zhang, Wen Qi, Lin Ye
Environmental Toxicology and Pharmacology.2022; 96: 104007. CrossRef
- Clinical Study
- Effects of a Portfolio-Mediterranean Diet and a Mediterranean Diet with or without a Sterol-Enriched Yogurt in Individuals with Hypercholesterolemia
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Yvelise Ferro, Elisa Mazza, Mariantonietta Salvati, Emma Santariga, Salvatore Giampà, Rocco Spagnuolo, Patrizia Doldo, Roberta Pujia, Adriana Coppola, Carmine Gazzaruso, Arturo Pujia, Tiziana Montalcini
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Endocrinol Metab. 2020;35(2):298-307. Published online June 24, 2020
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DOI: https://doi.org/10.3803/EnM.2020.35.2.298
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Abstract
PDFSupplementary MaterialPubReader ePub
- Background
A growing number of functional foods have been proposed to reduce cholesterol levels and the Portfolio Diet, which includes a combination of plant sterols, fibres, nuts, and soy protein, reduces low density lipoprotein cholesterol (LDL-C) from 20% to 30% in individuals with hyperlipidaemia. In this pilot study, the aim was to investigate whether a Mediterranean Diet incorporating a new and simple combination of cholesterol-lowering foods, excluding soy and nuts (namely the Portfolio-Mediterranean Diet), would reduce LDL-C levels, in the short-term, better than a Mediterranean Diet plus a sterol-enriched yogurt or a Mediterranean Diet alone.
Methods
We retrospectively evaluated 24 individuals on a Portfolio-Mediterranean Diet and 48 matched individuals on a Mediterranean Diet with or without a sterol-enriched yogurt (24 each groups) as controls.
Results
At follow-up (after 48±12 days), we observed an LDL reduction of 21±4, 23±4, and 44±4 mg/dL in the Mediterranean Diet alone, Mediterranean Diet plus yogurt and Portfolio-Mediterranean Diet respectively (P<0.001).
Conclusion
A Portfolio-Mediterranean Diet, incorporating a new combination of functional foods such as oats or barley, plant sterols, chitosan, and green tea but not soy and nuts, may reduce LDL of 25% in the short term in individuals with hypercholesterolemia.
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Citations
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- Intrinsic and environmental basis of aging: A narrative review
Carla Navarro, Juan Salazar, María P. Díaz, Maricarmen Chacin, Raquel Santeliz, Ivana Vera, Luis D′Marco, Heliana Parra, Mary Carlota Bernal, Ana Castro, Daniel Escalona, Henry García-Pacheco, Valmore Bermúdez
Heliyon.2023; 9(8): e18239. CrossRef - Application of small angle X‐ray scattering in exploring the effect of edible oils with different unsaturation FAs on bioaccessibility of stigmasterol oleate
Ying Wang, Tao Wang, Zhangtie Wang, Yiwen Guo, Ruijie Liu, Ming Chang
Journal of the Science of Food and Agriculture.2023; 103(15): 7764. CrossRef - Phyto-Enrichment of Yogurt to Control Hypercholesterolemia: A Functional Approach
Harsh Kumar, Kanchan Bhardwaj, Natália Cruz-Martins, Ruchi Sharma, Shahida Anusha Siddiqui, Daljeet Singh Dhanjal, Reena Singh, Chirag Chopra, Adriana Dantas, Rachna Verma, Noura S. Dosoky, Dinesh Kumar
Molecules.2022; 27(11): 3479. CrossRef - Familial Hypercholesterolemia and Its Current Diagnostics and Treatment Possibilities: A Literature Analysis
Kristina Zubielienė, Gintarė Valterytė, Neda Jonaitienė, Diana Žaliaduonytė, Vytautas Zabiela
Medicina.2022; 58(11): 1665. CrossRef - Mediterranean Diet a Potential Strategy against SARS-CoV-2 Infection: A Narrative Review
Yvelise Ferro, Roberta Pujia, Samantha Maurotti, Giada Boragina, Angela Mirarchi, Patrizia Gnagnarella, Elisa Mazza
Medicina.2021; 57(12): 1389. CrossRef
Review Article
- Calcium and Cardiovascular Disease
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Ian R. Reid, Sarah M. Birstow, Mark J. Bolland
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Endocrinol Metab. 2017;32(3):339-349. Published online September 18, 2017
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DOI: https://doi.org/10.3803/EnM.2017.32.3.339
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Abstract
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Circulating calcium is a risk factor for vascular disease, a conclusion arising from prospective studies involving hundreds of thousands of participants and extending over periods of up to 30 years. These associations may be partially mediated by other cardiovascular risk factors such as circulating lipid levels, blood pressure, and body mass index, but there appears to be a residual independent effect of serum calcium. Polymorphisms of the calcium-sensing receptor associated with small elevations of serum calcium are also associated with cardiovascular disease, suggesting that calcium plays a causative role. Trials of calcium supplements in patients on dialysis and those with less severe renal failure demonstrate increased mortality and/or acceleration of vascular disease, and meta-analyses of trials in those without overt renal disease suggest a similar adverse effect. Interpretation of the latter trials is complicated by a significant interaction between baseline use of calcium supplements and the effect of randomisation to calcium in the largest trial. Restriction of analysis to those who are calcium-naive demonstrates a consistent adverse effect. Observational studies of dietary calcium do not demonstrate a consistent adverse effect on cardiovascular health, though very high or very low intakes may be deleterious. Thus, obtaining calcium from the diet rather than supplements is to be encouraged.
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Citations
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- Cardiovascular and Cerebrovascular Outcomes With Vitamin D Supplementation: A Systematic Review and Meta-Analysis
Jishanth Mattumpuram, Muhammad Talha Maniya, Sabeeh Khawar Faruqui, Aymen Ahmed, Vikash Jaiswal, Sreedevi Pallath Harshakumar
Current Problems in Cardiology.2024; 49(1): 102119. CrossRef - 43Ca MAS-DNP NMR of Frozen Solutions for the Investigation of Calcium Ion Complexation
Tristan Georges, Romain Chèvre, Samuel F. Cousin, Christel Gervais, Pierre Thureau, Giulia Mollica, Thierry Azaïs
ACS Omega.2024; 9(4): 4881. CrossRef - Association between Daily Dietary Calcium Intake and the Risk of Cardiovascular Disease (CVD) in Postmenopausal Korean Women
Jae Kyung Lee, Thi Minh Chau Tran, Euna Choi, Jinkyung Baek, Hae-Rim Kim, Heeyon Kim, Bo Hyon Yun, Seok Kyo Seo
Nutrients.2024; 16(7): 1043. CrossRef - Case Series Analysis of Chronic Venous Insufficiency Patients to Determine Associated Arthrosis
Malay Patel, Roy Varghese, Manjusha Rajarshi
Indian Journal of Surgery.2023; 85(S1): 106. CrossRef - Prevalence of asteroid hyalosis and systemic risk factors in United States adults
Ryan Duong, Xiaoyu Cai, Naveen Ambati, Yevgeniy Shildkrot, Rebecca Sieburth
Eye.2023; 37(8): 1678. CrossRef - L-shaped association of serum calcium with all-cause and CVD mortality in the US adults: A population-based prospective cohort study
Xinran Hou, Jie Hu, Zhuoyi Liu, E. Wang, Qulian Guo, Zhong Zhang, Zongbin Song
Frontiers in Nutrition.2023;[Epub] CrossRef - The genetic correlation and causal association between key factors that influence vascular calcification and cardiovascular disease incidence
Xiaolin Ni, Lei Liu, Yao Yao, Chi Zhang, Huabin Su, Yuan Lv, Rongqiao Li, Liang Sun, Qi Zhou, Xiaoquan Zhu, Ze Yang, Zuoguan Chen, Wei He, Huolan Zhu, Shenqi Zhang, Caiyou Hu, Huiping Yuan
Frontiers in Cardiovascular Medicine.2023;[Epub] CrossRef - The association of long-term calcium and dairy products intake in adolescence with carotid intima media thickness and metabolic syndrome in early adulthood: Tehran Lipid and Glucose Study
Assa AkbarySedigh, Golaleh Asghari, Maryam Mahdavi, Parvin Mirmiran, Majid Valizadeh, Fereidoun Azizi
Nutrition & Metabolism.2023;[Epub] CrossRef - Effect Modification of Kidney Function on the Non-linear Association Between Serum Calcium Levels and Cardiovascular Mortality in Korean Adults
Jung-Ho Yang, Sun-Seog Kweon, Young-Hoon Lee, Seong-Woo Choi, So-Yeon Ryu, Hae-Sung Nam, Hye-Yeon Kim, Min-Ho Shin
Journal of Preventive Medicine and Public Health.2023; 56(3): 282. CrossRef - The Relationship between Mortality from Cardiovascular Diseases and Total Drinking Water Hardness: Systematic Review with Meta-Analysis
Aleksandra Bykowska-Derda, Marcin Spychala, Magdalena Czlapka-Matyasik, Mariusz Sojka, Jerzy Bykowski, Mariusz Ptak
Foods.2023; 12(17): 3255. CrossRef - Association Between Calcium Supplementation and the Risk of Cardiovascular Disease and Stroke: A Systematic Review and Meta-Analysis
Ming Gin Sim, Yao Neng Teo, Yao Hao Teo, Nicholas L. Syn, Tony Y.W. Li, Leonard L.L. Yeo, William K.F. Kong, Benjamin Y.Q. Tan, James W. Yip, Raymond C.C. Wong, Kian Keong Poh, Tiong-Cheng Yeo, Vijay Kumar Sharma, Ping Chai, Mark Y. Chan, Ching-Hui Sia
Heart, Lung and Circulation.2023; 32(10): 1230. CrossRef - Omega-3 long-chain polyunsaturated fatty acids: Metabolism and health implications
Imad Khan, Mudassar Hussain, Bangzhi Jiang, Lei Zheng, Yuechao Pan, Jijie Hu, Adil Khan, Azqa Ashraf, Xiaoqiang Zou
Progress in Lipid Research.2023; 92: 101255. CrossRef - The role of chromium supplementation in cardiovascular risk factors: A comprehensive reviews of putative molecular mechanisms
Dhiaa lattef Gossa Al-Saadde, Ali Murtaza Haider, Arsalan Ali, Ebraheem Abdu Musad Saleh, Abduladheem Turki Jalil, Furqan M. Abdulelah, Rosario Mireya Romero-Parra, Nahla A. Tayyib, Andrés Alexis Ramírez-Coronel, Ameer S. Alkhayyat
Heliyon.2023; 9(9): e19826. CrossRef - Calcium as an essential macronutrient: benefits and risks for cardiovascular and other body systems
A.V. Gostry, R.A. Bekker, Yu.V. Bykov
Profilakticheskaya meditsina.2023; 26(10): 109. CrossRef - Association of Genotypes of ANGPTL3 with Vitamin D and Calcium Concentration in Cardiovascular Disease
Malihe Aghasizadeh, Mahmoud Ghanei, Sahar Ghoflchi, Parisa Asadian-sohan, Mohammad Haghani, Tooba Kazemi, Habibollah Esmaily, Amir Avan, Gordon A. Ferns, Ebrahim Miri-Moghaddam, Majid Ghayour-Mobarhan
Biochemical Genetics.2023;[Epub] CrossRef - Bone-friendly lifestyle and the role of calcium or vitamin D supplementation
I. R. Reid
Climacteric.2022; 25(1): 37. CrossRef - Cardiovascular risks associated with calcium supplementation in patients with osteoporosis: a nationwide cohort study
Kyoung Jin Kim, Min Sun Kim, Namki Hong, Jae Hyun Bae, Kyeong Jin Kim, Nam Hoon Kim, Yumie Rhee, Juneyoung Lee, Sin Gon Kim
European Heart Journal - Cardiovascular Pharmacotherapy.2022; 8(6): 568. CrossRef - Cyclic voltammetric determination of calcium in water in the presence of natural organic matter (humic acid) and Cu (II) at gold electrode's surface
Olayemi J. Fakayode, Thabo T.I. Nkambule
Food Chemistry Advances.2022; 1: 100012. CrossRef - Low serum concentration of zinc, selenium, calcium, potassium and high serum concentration of iron, sodium are associated with myocardial infarction
S. M. Naim Uddin, Md. Zahedur Rahaman, Thanmin Jarana Thammi, Mohammad Rashedul Islam, Md. Iftikhar Uddin Masud, Md. Giash Uddin, Mohammad Safiqul Islam
Aging and Health Research.2022; 2(1): 100063. CrossRef - Organelle-specific blue-emitting two-photon probes for calcium ions: Combination with green-emitting two-photon probe for simultaneous detection of proton ions
Seung Taek Hong, Mun Seok Kim, Bo Ra Kim, Eun Jeong Lee, Yeo Uk Yoon, Kyu Cheol Paik, Man So Han, Eun Sun Kim, Bong Rae Cho
Talanta.2022; 244: 123408. CrossRef - Plasma Calcium and Phosphorus Levels and Cardiovascular Disease Risks in Egyptian Type 2 Diabetic Patients
Sahar Al-Okbi, Seham Sabry, Enas S. K. Al-Siedy, Shaimaa Elsayed
Open Access Macedonian Journal of Medical Sciences.2022; 10(A): 502. CrossRef - The Incidence of Serum Calcium Elevation due to Adrenal Insufficiency After Unilateral Adrenalectomy
Woochul Kim, Jee-Hye Choi, Ja Kyung Lee, Chang Ho Ahn, Hyeong Won Yu, June Young Choi
Journal of Endocrine Surgery.2022; 22(1): 18. CrossRef - Calcium Supplementation, Risk of Cardiovascular Diseases, and Mortality: A Real-World Study of the Korean National Health Insurance Service Data
Jae-Min Park, Bora Lee, Young-Sang Kim, Kyung-Won Hong, Yon Chul Park, Dong Hyeok Shin, Yonghwan Kim, Kunhee Han, Kwangyoon Kim, Junghwa Shin, Mina Kim, Bom-Taeck Kim
Nutrients.2022; 14(12): 2538. CrossRef - Physical Fitness and Dietary Intake Improve Mental Health in Chinese Adolescence Aged 12–13
Wenjie Liang, Jian Fu, Xin Tian, Jiaxue Tian, Yu Yang, Wencui Fan, Zijuan Du, Zheyu Jin
Frontiers in Integrative Neuroscience.2022;[Epub] CrossRef - EXTENSIVE EXPERTISE IN ENDOCRINOLOGY: Osteoporosis management
Ian R Reid
European Journal of Endocrinology.2022; 187(4): R65. CrossRef - Evaluation of the Increase in Serum Calcium Levels After Unilateral Adrenalectomy
Mehmet Üstün, Korhan Tuncer
Cureus.2022;[Epub] CrossRef - Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D
William B. Grant, Barbara J. Boucher, Fatme Al Anouti, Stefan Pilz
Nutrients.2022; 14(18): 3811. CrossRef - Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria
Yan Zhong Liu, Zong Xiang Li, Lin Lin Zhang, Dan Wang, Yi Ping Liu
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Association between serum calcium level and in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study
Dingfeng Fang, Haibo Chen
Scientific Reports.2022;[Epub] CrossRef - Calcium and vitamin D supplements for the treatment and prevention of osteoporosis. Should it be widely used?
Yuliya A. Kaminarskaya
Clinical nutrition and metabolism.2022; 3(3): 167. CrossRef - Calcium Signalling in Heart and Vessels: Role of Calmodulin and Downstream Calmodulin-Dependent Protein Kinases
Sofia Beghi, Malgorzata Furmanik, Armand Jaminon, Rogier Veltrop, Nikolas Rapp, Kanin Wichapong, Elham Bidar, Annamaria Buschini, Leon J. Schurgers
International Journal of Molecular Sciences.2022; 23(24): 16139. CrossRef - Childhood and long-term dietary calcium intake and adult cardiovascular risk in a population with high calcium intake
Feitong Wu, Katja Pahkala, Markus Juonala, Suvi P. Rovio, Matthew A. Sabin, Tapani Rönnemaa, Kylie J. Smith, Antti Jula, Terho Lehtimäki, Nina Hutri-Kähönen, Mika Kähönen, Tomi Laitinen, Jorma S.A. Viikari, Olli T. Raitakari, Costan G. Magnussen
Clinical Nutrition.2021; 40(4): 1926. CrossRef - Collagen networks within 3D PEG hydrogels support valvular interstitial cell matrix mineralization
Megan E. Schroeder, Andrea Gonzalez Rodriguez, Kelly F. Speckl, Cierra J. Walker, Firaol S. Midekssa, Joseph C. Grim, Robert M. Weiss, Kristi S. Anseth
Acta Biomaterialia.2021; 119: 197. CrossRef - Effects of High-Impact Weight-Bearing Exercise on Bone Mineral Density and Bone Metabolism in Middle-Aged Premenopausal Women: A Randomized Controlled Trial
Sung-Woo Kim, Myong-Won Seo, Hyun-Chul Jung, Jong-Kook Song
Applied Sciences.2021; 11(2): 846. CrossRef - Higher Intakes of Potassium and Magnesium, but Not Lower Sodium, Reduce Cardiovascular Risk in the Framingham Offspring Study
R. Taylor Pickering, M. Loring Bradlee, Martha R. Singer, Lynn L. Moore
Nutrients.2021; 13(1): 269. CrossRef - Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry
Timo Schmitz, Christian Thilo, Jakob Linseisen, Margit Heier, Annette Peters, Bernhard Kuch, Christa Meisinger
Scientific Reports.2021;[Epub] CrossRef - Edible Insects versus Meat—Nutritional Comparison: Knowledge of Their Composition Is the Key to Good Health
Agnieszka Orkusz
Nutrients.2021; 13(4): 1207. CrossRef - The Role of Essential Oils and Their Main Compounds in the Management of Cardiovascular Disease Risk Factors
Jorge M. Alves-Silva, Mónica Zuzarte, Henrique Girão, Lígia Salgueiro
Molecules.2021; 26(12): 3506. CrossRef - Polymorphism rs7214723 in CAMKK1: a new genetic variant associated with cardiovascular diseases
Sofia Beghi, Francesca Cavaliere, Matteo Manfredini, Sandro Ferrarese, Claudio Corazzari, Cesare Beghi, Annamaria Buschini
Bioscience Reports.2021;[Epub] CrossRef - The Role of Serum Calcium Levels in Pediatric Dyslipidemia: Are There Any?
Yaguang Peng, Lixin Hu, Xiaolu Nie, Siyu Cai, Ruohua Yan, Yali Liu, Yanying Cai, Wenqi Song, Xiaoxia Peng
Frontiers in Pediatrics.2021;[Epub] CrossRef - The impact of serum 25-hydroxyvitamin D, calcium, and parathyroid hormone levels on the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study
Songzan Chen, Fangkun Yang, Tian Xu, Yao Wang, Kaijie Zhang, Guosheng Fu, Wenbin Zhang
Nutrition Journal.2021;[Epub] CrossRef - Temporal Relationship Between Changes in Serum Calcium and Hypercholesteremia and Its Impact on Future Brachial-Ankle Pulse Wave Velocity Levels
Xing Meng, Tianshu Han, Wenbo Jiang, Fengli Dong, Hongxue Sun, Wei Wei, Yageng Yan
Frontiers in Nutrition.2021;[Epub] CrossRef - The Evidence and Controversy Between Dietary Calcium Intake and Calcium Supplementation and the Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Cohort Studies and Randomized Controlled Trials
Chao Yang, Xiangling Shi, Hui Xia, Xian Yang, Hechun Liu, Da Pan, Guiju Sun
Journal of the American College of Nutrition.2020; 39(4): 352. CrossRef - Association between the cumulative exposure to bisphosphonates and hospitalization for atherosclerotic cardiovascular events: A population-based study
Manuela Casula, Elena Olmastroni, Federica Galimberti, Elena Tragni, Giovanni Corrao, Lorenza Scotti, Alberico L. Catapano
Atherosclerosis.2020; 301: 1. CrossRef - Calcium and/or Vitamin D Supplementation for the Prevention of Fragility Fractures: Who Needs It?
Ian R Reid, Mark J Bolland
Nutrients.2020; 12(4): 1011. CrossRef - Oxalates, urinary stones and risk of cardiovascular diseases
Ahmed Arafa, Ehab S. Eshak, Hiroyasu Iso
Medical Hypotheses.2020; 137: 109570. CrossRef - A dual signal on-off fluorescent nanosensor for the simultaneous detection of copper and creatinine
Resmi V. Nair, Parvathy Radhakrishna Pillai Suma, Ramapurath S. Jayasree
Materials Science and Engineering: C.2020; 109: 110569. CrossRef - Soy isoflavones interact with calcium and contribute to blood pressure homeostasis in women: a randomized, double-blind, placebo controlled trial
Lee-Jane W. Lu, Nai-Wei Chen, Fatima Nayeem, Manubai Nagamani, Karl E. Anderson
European Journal of Nutrition.2020; 59(6): 2369. CrossRef - Associations between diet and mental health using the 12-item General Health Questionnaire: cross-sectional and prospective analyses from the Japan Multi-Institutional Collaborative Cohort Study
Naoki Choda, Kenji Wakai, Mariko Naito, Nahomi Imaeda, Chiho Goto, Kenta Maruyama, Yuka Kadomatsu, Mineko Tsukamoto, Tae Sasakabe, Yoko Kubo, Rieko Okada, Sayo Kawai, Takashi Tamura, Asahi Hishida, Kenji Takeuchi, Atsuyoshi Mori, Nobuyuki Hamajima
Nutrition Journal.2020;[Epub] CrossRef - Vitamin D supplementation and incident preeclampsia: A systematic review and meta-analysis of randomized clinical trials
Silvia Fogacci, Federica Fogacci, Maciej Banach, Erin D. Michos, Adrian V. Hernandez, Gregory Y.H. Lip, Michael J. Blaha, Peter P. Toth, Claudio Borghi, Arrigo F.G. Cicero
Clinical Nutrition.2020; 39(6): 1742. CrossRef - Establishing Benefit from Vitamin D Supplementation — Adherence to Defined Criteria and Targeting of High-Risk Groups Essential?
Siobhán McGettigan, P. Mulkerrin, P.M. O'Shea, S.T. O'Keeffe, E.C. Mulkerrin
The Journal of nutrition, health and aging.2020; 24(8): 827. CrossRef - Nutritional Quality and Health Effects of Low Environmental Impact Diets: The “Seguimiento Universidad de Navarra” (SUN) Cohort
Ujué Fresán, Winston J. Craig, Miguel A. Martínez-González, Maira Bes-Rastrollo
Nutrients.2020; 12(8): 2385. CrossRef - Beyond Fish Oil Supplementation: The Effects of Alternative Plant Sources of Omega-3 Polyunsaturated Fatty Acids upon Lipid Indexes and Cardiometabolic Biomarkers—An Overview
Heitor O. Santos, James C. Price, Allain A. Bueno
Nutrients.2020; 12(10): 3159. CrossRef - Oxidative stress by Ca2+ overload is critical for phosphate-induced vascular calcification
Nhung Thi Nguyen, Tuyet Thi Nguyen, Dat Da Ly, Jing-Bo Xia, Xu-Feng Qi, In-Kyu Lee, Seung-Kuy Cha, Kyu-Sang Park
American Journal of Physiology-Heart and Circulatory Physiology.2020; 319(6): H1302. CrossRef - A Naringin- and Icariin-Contained Herbal Formula, Gushukang, Ameliorated Aged Osteoporosis of Aged Mice with High Calcium Intake
Xiao-Li Li, Fei Xu, Fu-Hui Lin, Lian-Zhong Ai, Yong-Jian Zhao, Xiao-Lei Bi, Li Sui, Yan Zhang
The American Journal of Chinese Medicine.2020; 48(07): 1671. CrossRef - Gushukang exerts osteopreserve effects by regulating vitamin D and calcium metabolism in ovariectomized mice
Xiao-Li Li, Liang Wang, Xiao-Lei Bi, Bing-Bing Chen, Yan Zhang
Journal of Bone and Mineral Metabolism.2019; 37(2): 224. CrossRef - Genetic predisposition to increased serum calcium, bone mineral density, and fracture risk in individuals with normal calcium levels: mendelian randomisation study
Agustin Cerani, Sirui Zhou, Vincenzo Forgetta, John A Morris, Katerina Trajanoska, Fernando Rivadeneira, Susanna C Larsson, Karl Michaëlsson, J Brent Richards
BMJ.2019; : l4410. CrossRef - Protective Effects of Phenylpropanoids and Phenylpropanoid-rich Essential Oils on the Cardiovascular System
Jorge M. Alves-Silva, Mónica Zuzarte, Carla Marques, Henrique Girão, Lígia Salgueiro
Mini-Reviews in Medicinal Chemistry.2019; 19(17): 1459. CrossRef - Borderline high serum calcium levels are associated with arterial stiffness and 10‐year cardiovascular disease risk determined by Framingham risk score
Byoungjin Park, Yong‐Jae Lee
The Journal of Clinical Hypertension.2019; 21(5): 668. CrossRef - Effects of IGF-1 on the Cardiovascular System
Milan Obradovic, Sonja Zafirovic, Sanja Soskic, Julijana Stanimirovic, Andreja Trpkovic, Danimir Jevremovic, Esma R. Isenovic
Current Pharmaceutical Design.2019; 25(35): 3715. CrossRef - Associations between serum calcium, 25(OH)D level and bone mineral density in older adults
Minbo Liu, Xiaocong Yao, Zhongxin Zhu
Journal of Orthopaedic Surgery and Research.2019;[Epub] CrossRef - Controversies in medicine: the role of calcium and vitamin D supplements in adults
Ian R Reid, Mark J Bolland
Medical Journal of Australia.2019; 211(10): 468. CrossRef - Structural insight into TRPV5 channel function and modulation
Shangyu Dang, Mark K. van Goor, Daniel Asarnow, YongQiang Wang, David Julius, Yifan Cheng, Jenny van der Wijst
Proceedings of the National Academy of Sciences.2019; 116(18): 8869. CrossRef - Serum calcium levels independently predict in-hospital mortality in patients with acute myocardial infarction
A. Shiyovich, Y. Plakht, H. Gilutz
Nutrition, Metabolism and Cardiovascular Diseases.2018; 28(5): 510. CrossRef - Primary Bone Marrow B-Cell Lymphoma Undetected by Multiple Imaging Modalities That Initially Presented with Hypercalcemia
Jin Sae Yoo, Juwon Kim, Hyeong Ju Kwon, Jung Soo Lim
Case Reports in Endocrinology.2018; 2018: 1. CrossRef - Dietary Micronutrient and Mineral Intake in the Mediterranean Healthy Eating, Ageing, and Lifestyle (MEAL) Study
Dora Castiglione, Armando Platania, Alessandra Conti, Mariagiovanna Falla, Maurizio D’Urso, Marina Marranzano
Antioxidants.2018; 7(7): 79. CrossRef - Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes
Christopher Dedic, Tin Shing Hung, Alan M. Shipley, Akira Maeda, Thomas Gardella, Andrew L. Miller, Paola Divieti Pajevic, Joseph G. Kunkel, Alessandro Rubinacci
Bone.2018; 116: 135. CrossRef - Effects of Altered Calcium Metabolism on Cardiac Parameters in Primary Aldosteronism
Jung Soo Lim, Namki Hong, Sungha Park, Sung Il Park, Young Taik Oh, Min Heui Yu, Pil Yong Lim, Yumie Rhee
Endocrinology and Metabolism.2018; 33(4): 485. CrossRef
Original Articles
- Endocrine Research
- The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes
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Cheol Ryong Ku, Yoon Hee Cho, Zhen-Yu Hong, Ha Lee, Sue Ji Lee, Seung-soo Hong, Eun Jig Lee
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Endocrinol Metab. 2016;31(2):328-335. Published online April 8, 2016
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DOI: https://doi.org/10.3803/EnM.2016.31.2.328
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4,163
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Abstract
PDFPubReader
- Background
Resveratrol (RSV) is a polyphenolic phytoalexin that has many effects on metabolic diseases such as diabetes and obesity. Given the importance of brown adipose tissue (BAT) for energy expenditure, we investigated the effects of RSV on brown adipocytes.
MethodsFor the in vitro study, interscapular BAT was isolated from 7-week-old male Sprague Dawley rats. For the in vivo study, 7-week-old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were divided into four groups and treated for 27 weeks with: standard diet (SD); SD+RSV (10 mg/kg body weight, daily); high fat diet (HFD); HFD+RSV. RSV was provided via oral gavage once daily during the in vivo experiments.
ResultsRSV treatment of primary cultured brown preadipocytes promoted mitochondrial activity, along with over-expression of estrogen receptor α (ER-α). In OLETF rats, both HFD and RSV treatment increased the weight of BAT and the differentiation of BAT. However, only RSV increased the mitochondrial activity and ER-α expression of BAT in the HFD-fed group. Finally, RSV improved the insulin sensitivity of OLETF rats by increasing the mitochondrial activity of BAT, despite having no effects on white adipocytes and muscles in either diet group.
ConclusionRSV could improve insulin resistance, which might be associated with mitochondrial activity of brown adipocyte. Further studies evaluating the activity of RSV for both the differentiation and mitochondrial activity of BAT could be helpful in investigating the effects of RSV on metabolic parameters.
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- Natural Bioactive Compounds from Foods Inhibited Pigmentation Especially Potential Application of Fucoxanthin to Chloasma: a Mini-Review
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Weichu Tao, Hu Zhang, Xia Jiang, Ning Chen
Food Science and Human Wellness.2024; 13(2): 597. CrossRef - The Potential to Fight Obesity with Adipogenesis Modulating Compounds
Jiaqi Zhao, Ailin Zhou, Wei Qi
International Journal of Molecular Sciences.2022; 23(4): 2299. CrossRef - Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
Liwen Wang, Jie Hu, Haiyan Zhou
The World Journal of Men's Health.2021; 39(4): 606. CrossRef - Precision Nutrition to Activate Thermogenesis as a Complementary Approach to Target Obesity and Associated-Metabolic-Disorders
Marina Reguero, Marta Gómez de Cedrón, Sonia Wagner, Guillermo Reglero, José Carlos Quintela, Ana Ramírez de Molina
Cancers.2021; 13(4): 866. CrossRef - Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence
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Francisco J Osuna-Prieto, Borja Martinez-Tellez, Antonio Segura-Carretero, Jonatan R Ruiz
Advances in Nutrition.2021; 12(6): 2147. CrossRef - Role of Dietary Polyphenols in Adipose Tissue Browning: A Narrative Review
Juan Salazar, Clímaco Cano, José L. Pérez, Ana Castro, María P. Díaz, Bermary Garrido, Rubén Carrasquero, Maricarmen Chacín, Manuel Velasco, Luis D´Marco, Joselyn Rojas-Quintero, Valmore Bermúdez
Current Pharmaceutical Design.2020; 26(35): 4444. CrossRef - Brown and Brite: The Fat Soldiers in the Anti-obesity Fight
Shireesh Srivastava, Richard L. Veech
Frontiers in Physiology.2019;[Epub] CrossRef - Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity
Oh Yoen Kim, Ji Yeon Chung, Juhyun Song
Pharmacological Research.2019; 148: 104411. CrossRef - Ginsenoside Rb2 Alleviates Obesity by Activation of Brown Fat and Induction of Browning of White Fat
Yilian Hong, Yi Lin, Qiya Si, Lijuan Yang, Weisong Dong, Xuejiang Gu
Frontiers in Endocrinology.2019;[Epub] CrossRef - Programming of the Beige Phenotype in White Adipose Tissue of Adult Mice by Mild Resveratrol and Nicotinamide Riboside Supplementations in Early Postnatal Life
Alba Serrano, Madhu Asnani-Kishnani, Ana María Rodríguez, Andreu Palou, Joan Ribot, María Luisa Bonet
Molecular Nutrition & Food Research.2018;[Epub] CrossRef - Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis
Tanila Wood dos Santos, Quélita Cristina Pereira, Lucimara Teixeira, Alessandra Gambero, Josep A. Villena, Marcelo Lima Ribeiro
International Journal of Molecular Sciences.2018; 19(9): 2757. CrossRef - Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue
Perla P. Argentato, Helena de Cássia César, Débora Estadella, Luciana P. Pisani
British Journal of Nutrition.2018; 120(6): 619. CrossRef - Effects of Genistein on Differentiation and Viability of Human Visceral Adipocytes
Elena Grossini, Serena Farruggio, Giulia Raina, David Mary, Giacomo Deiro, Sergio Gentilli
Nutrients.2018; 10(8): 978. CrossRef - A comprehensive review of the health perspectives of resveratrol
Abdur Rauf, Muhammad Imran, Hafiz Ansar Rasul Suleria, Bashir Ahmad, Dennis G. Peters, Mohammad S. Mubarak
Food & Function.2017; 8(12): 4284. CrossRef - The Role of Circulating Slit2, the One of the Newly Batokines, in Human Diabetes Mellitus
Yea Eun Kang, Sorim Choung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
Endocrinology and Metabolism.2017; 32(3): 383. CrossRef - A nutritional perspective on UCP1-dependent thermogenesis
M. Luisa Bonet, Josep Mercader, Andreu Palou
Biochimie.2017; 134: 99. CrossRef - The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity
Yueshui Zhao, Bo Chen, Jing Shen, Lin Wan, Yinxin Zhu, Tao Yi, Zhangang Xiao
Oxidative Medicine and Cellular Longevity.2017; 2017: 1. CrossRef - Articles inEndocrinology and Metabolismin 2016
Won-Young Lee
Endocrinology and Metabolism.2017; 32(1): 62. CrossRef - Antiobesity effects of resveratrol: which tissues are involved?
Alfredo Fernández‐Quintela, Iñaki Milton‐Laskibar, Marcela González, Maria P. Portillo
Annals of the New York Academy of Sciences.2017; 1403(1): 118. CrossRef - Resveratrol attenuates triglyceride accumulation associated with upregulation of Sirt1 and lipoprotein lipase in 3T3-L1 adipocytes
Haruki Imamura, Daiji Nagayama, Noriko Ishihara, Syo Tanaka, Rena Watanabe, Yasuhiro Watanabe, Yuta Sato, Takashi Yamaguchi, Noriko Ban, Hidetoshi Kawana, Masahiro Ohira, Kei Endo, Atsuhito Saiki, Kohji Shirai, Ichiro Tatsuno
Molecular Genetics and Metabolism Reports.2017; 12: 44. CrossRef - Resveratrol has dose-dependent effects on DNA fragmentation and mitochondrial activity of ovine secondary follicles cultured in vitro
T.J.S. Macedo, V.R.P. Barros, A.P.O. Monte, B.B. Gouveia, M.É.S. Bezerra, A.Y.P. Cavalcante, R.S. Barberino, V.G. Menezes, M.H.T. Matos
Zygote.2017; 25(4): 434. CrossRef - Response: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes (Endocrinol Metab2016;31:328-35, Cheol Ryong Ku et al.)
Cheol Ryong Ku, Eun Jig Lee
Endocrinology and Metabolism.2016; 31(3): 482. CrossRef - Letter: The Effects of High Fat Diet and Resveratrol on Mitochondrial Activity of Brown Adipocytes (Endocrinol Metab2016;31:328-35, Cheol Ryong Ku et al.)
Ji-Young Cha
Endocrinology and Metabolism.2016; 31(3): 480. CrossRef
- Obesity and Metabolism
- Associations between Dietary Acid-Base Load and Cardiometabolic Risk Factors in Adults: The Tehran Lipid and Glucose Study
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Zahra Bahadoran, Parvin Mirmiran, Hadise Khosravi, Fereidoun Azizi
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Endocrinol Metab. 2015;30(2):201-207. Published online June 30, 2015
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DOI: https://doi.org/10.3803/EnM.2015.30.2.201
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Abstract
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- Background
In this study we investigated the associations of dietary acid-base load, identified by potential renal acid load (PRAL) and protein to potassium (Pro:K) ratio, with cardiometabolic risk factors in Tehranian adults.
MethodsA cross-sectional study was conducted within the framework of the fourth phase of the Tehran Lipid and Glucose Study (2009 to 2011) on 5,620 men and women aged 19 to 70 years. Dietary data were collected by a trained dietitian using a validated, 147-food item, semi-quantitative food frequency questionnaire, and dietary PRAL and Pro:K ratio were calculated. Multiple linear regression models with adjustment for potential confounding variables were used to evaluate the associations of dietary acid-base load with anthropometric measures, blood pressure, serum triglycerides, high density lipoprotein cholesterol (HDL-C), serum creatinine, and fasting blood glucose.
ResultsThe mean±SD age of the participants was 39.8±12.8 years and 54% of participants were women. Mean±SD PRAL was -22.0±29.1; mean PRAL was -15.6 in men and -26.8 in women. Dietary PRAL was associated with weight (β=0.098, P<0.001), waist circumference (β=0.062, P<0.01), serum triglycerides (β=0.143, P<0.01), HDL-C (β=-0.11, P<0.01), diastolic blood pressure (β=0.062, P<0.01), and serum creatinine (β=0.142, P<0.001). Pro:K ratio was associated with weight (β=0.055, P<0.001), waist circumference (β=0.04, P<0.01), serum HDL-C (β=-0.06, P<0.01), serum triglycerides (β=0.03, P<0.05), diastolic blood pressure (β=0.026, P<0.05), and serum creatinine (β=0.07, P<0.01).
ConclusionA more acidic dietary acid-base load may be a risk factor for the development of metabolic disorders.
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Citations
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- A high dietary acid load can potentially exacerbate cardiometabolic risk factors: An updated systematic review and meta-analysis of observational studies
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Critical Reviews in Food Science and Nutrition.2023; 63(28): 9033. CrossRef - Health Inequities in the USA: a Role for Dietary Acid Load? Results from the National Health and Nutrition Examination Surveys
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Journal of Racial and Ethnic Health Disparities.2023; 10(6): 2851. CrossRef - Dietary acid load is associated with waist circumference in university students with low adherence to the Mediterranean diet: The potential role of ultra-processed foods
Paraskevi Detopoulou, Vassilios Dedes, Ioanna Pylarinou, Dimitra Syka, Konstantinos Tzirogiannis, Georgios I. Panoutsopoulos
Clinical Nutrition ESPEN.2023; 56: 43. CrossRef - Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus
Faezeh Abaj, Zahra Esmaeily, Zeinab Naeini, Ehsan Alvandi, Masoumeh Rafiee, Fariba Koohdani
BMC Endocrine Disorders.2023;[Epub] CrossRef - A Nutrigenetic Approach to Investigate ApoB EcoR1 Polymorphism-Dietary Acid Load Interactions on Lipid and Anthropometric-Related Outcomes in Adults with Dyslipidemic Type 2 Diabetes
Zeinab Naeini, Faezeh Abaj, Zahra Esmaeily, Ehsan Alvandi, Masoumeh Rafiee, Fariba Koohdani
Lifestyle Genomics.2023; 16(1): 61. CrossRef - Interaction of dietary acid load and general and central obesity with muscle strength and skeletal muscle mass
Saba Mohammadpour, Parivash Ghorbaninejad, Mahshid Shahavandi, Sakineh Shab-Bidar
Clinical Nutrition ESPEN.2022; 48: 361. CrossRef - Dietary acid load modifies the effects of ApoA2–265 T > C polymorphism on lipid profile and serum leptin and ghrelin levels among type 2 diabetic patients
Faezeh Abaj, Zahra Esmaeily, Zeinab Naeini, Masoumeh Rafiee, Fariba Koohdani
BMC Endocrine Disorders.2022;[Epub] CrossRef - The association between dietary acid load and adiposity measures among children and adolescents
Nasim Sorraya, Arman Arab, Shokoofeh Talebi
BMC Pediatrics.2022;[Epub] CrossRef - Metabolic status is not related to dietary acid load in polycystic ovary syndrome
Tülay OMMA, Fatmanur Hümeyra ZENGİN, Süheyla AYDOĞMUŞ, Cavit ÇULHA
Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi.2022; 55(2): 111. CrossRef - EVALUATION OF THE RELATIONSHİP BETWEEN QUALITY OF LIFE AND DIETARY ACID LOAD IN OBESE WOMEN
Nurefşan KONYALIGİL, Betül ÇİÇEK, Tuba TEKİN, Meltem ÜNLÜSAVURAN SÖNMEZ
Karya Journal of Health Science.2022; 3(2): 145. CrossRef - Carbohydrate Intake and Its Association With Dietary Acid Load in U.S. Adults: Results From a Cross-Sectional Study
Maximilian A. Storz, Alvaro L. Ronco
American Journal of Lifestyle Medicine.2022; : 155982762211332. CrossRef - The association between dietary acid load and body composition in physical education students aged 18–25 years
Maryam Mansordehghan, Elnaz Daneshzad, Vahid Basirat, Bahram Pourghassem Gargari, Tohid Rouzitalab
Journal of Health, Population and Nutrition.2022;[Epub] CrossRef - Association of dietary acid load with anthropometric indices in children and adolescents
Zahra Aslani, Maryam Bahreynian, Nazli Namazi, Nitin Shivappa, James R. Hébert, Hamid Asayesh, Mohammad Esmaeil Motlagh, Mohammad Ali Pourmirzaei, Amir Kasaeian, Armita Mahdavi-Gorabi, Mostafa Qorbani, Roya Kelishadi
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.2021; 26(2): 555. CrossRef - Dietary acid load, kidney function and risk of chronic kidney disease: A systematic review and meta-analysis of observational studies
Manije Darooghegi Mofrad, Elnaz Daneshzad, Leila Azadbakht
International Journal for Vitamin and Nutrition Research.2021; 91(3-4): 343. CrossRef - The association between dietary acid load with cardiometabolic risk factors and inflammatory markers amongst elderly men: A cross‐sectional study
Alireza Jafari, Mahtab Ghanbari, Hossein Shahinfar, Nick Bellissimo, Leila Azadbakht
International Journal of Clinical Practice.2021;[Epub] CrossRef - Dietary Acid Load and Its Interaction with IGF1 (rs35767 and rs7136446) and IL6 (rs1800796) Polymorphisms on Metabolic Traits among Postmenopausal Women
Sook Yee Lim, Yoke Mun Chan, Vasudevan Ramachandran, Zalilah Mohd Shariff, Yit Siew Chin, Manohar Arumugam
Nutrients.2021; 13(7): 2161. CrossRef - Associations between dietary acid load and obesity among Iranian women
Somaye Fatahi, Mostafa Qorbani, Pamela J. Surkan, Leila Azadbakht
Journal of Cardiovascular and Thoracic Research.2021; 13(4): 285. CrossRef - Higher dietary acid load is not associated with risk of breast cancer in Iranian women
Maryam Safabakhsh, Hossein Imani, Mehdi Yaseri, Ramesh Omranipour, Sakineh Shab‐Bidar
Cancer Reports.2020;[Epub] CrossRef - Dietary acid load, blood pressure, fasting blood sugar and biomarkers of insulin resistance among adults: Findings from an updated systematic review and meta‐analysis
Parvin Dehghan, Mahdieh Abbasalizad Farhangi
International Journal of Clinical Practice.2020;[Epub] CrossRef - Ameliorating Chronic Kidney Disease Using a Whole Food Plant-Based Diet
Kathleen E. Adair, Rodney G. Bowden
Nutrients.2020; 12(4): 1007. CrossRef - Positive association between dietary acid load and future insulin resistance risk: findings from the Korean Genome and Epidemiology Study
Kyung Won Lee, Dayeon Shin
Nutrition Journal.2020;[Epub] CrossRef - Dietary Acid Load and Cardiometabolic Risk Factors—A Narrative Review
Joanna Ostrowska, Justyna Janiszewska, Dorota Szostak-Węgierek
Nutrients.2020; 12(11): 3419. CrossRef - Dietary acid load and cardiometabolic risk factors: a systematic review and meta-analysis of observational studies
Elnaz Daneshzad, Fahimeh Haghighatdoost, Leila Azadbakht
Public Health Nutrition.2019; 22(15): 2823. CrossRef - The Associations of Dietary Acid Load with Insulin Resistance and Type 2 Diabetes: A Systematic Review of Existing Human Studies
Hadi Emamat, Hadith Tangestani, Zahra Bahadoran, Sajjad Khalili-Moghadam, Parvin Mirmiran
Recent Patents on Food, Nutrition & Agriculture.2019; 10(1): 27. CrossRef - Association of dietary acid load with cardiovascular risk factors and the prevalence of metabolic syndrome in Iranian women: A cross-sectional study
Hadis Mozaffari, Nazli Namazi, Bagher Larijani, Nick Bellissimo, Leila Azadbakht
Nutrition.2019; 67-68: 110570. CrossRef - Higher dietary acid load potentially increases serum triglyceride and obesity prevalence in adults: An updated systematic review and meta-analysis
Mahdieh Abbasalizad Farhangi, Leila Nikniaz, Zeinab Nikniaz, Raffaele Serra
PLOS ONE.2019; 14(5): e0216547. CrossRef - Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery
Mahdieh Abbasalizad Farhangi, Mahdi Vajdi, Mahdi Najafi, Raffaele Serra
PLOS ONE.2019; 14(10): e0223830. CrossRef - Higher dietary acid load is associated with higher likelihood of peripheral arterial disease among American adults
Mohsen Mazidi, Dimitri P. Mikhailidis, Maciej Banach
Journal of Diabetes and its Complications.2018; 32(6): 565. CrossRef - Nutrition and Cardio-Metabolic Risk Factors: 20 Years of the Tehran Lipid and Glucose Study Findings
Firoozeh Hosseini-Esfahani, Somaye Hosseinipour, Golaleh Asghari, Zahra Bahadoran, Nazanin Moslehi, Mahdieh Golzarand, Hanieh Ejtahed, Parvin Mirmiran, Fereidoun Azizi
International Journal of Endocrinology and Metabolism.2018;[Epub] CrossRef - Higher dietary acid load is weakly associated with higher adiposity measures and blood pressure in Japanese adults: The National Health and Nutrition Survey
Kentaro Murakami, M. Barbara E. Livingstone, Hitomi Okubo, Satoshi Sasaki
Nutrition Research.2017; 44: 67. CrossRef - Accuracy and precision of estimation equations to predict net endogenous acid excretion using the Australian food database
Benjamin H. Parmenter, Gary J. Slater, Lynda A. Frassetto
Nutrition & Dietetics.2017; 74(3): 308. CrossRef - Dietary acid load and mortality among Japanese men and women: the Japan Public Health Center–based Prospective Study
Shamima Akter, Akiko Nanri, Tetsuya Mizoue, Mitsuhiko Noda, Norie Sawada, Shizuka Sasazuki, Shoichiro Tsugane
The American Journal of Clinical Nutrition.2017; 106(1): 146. CrossRef - Association between Dietary Acid Load and Insulin Resistance: Tehran Lipid and Glucose Study
Sajjad Khalili Moghadam, Zahra Bahadoran, Parvin Mirmiran, Maryam Tohidi, Fereidoun Azizi
Preventive Nutrition and Food Science.2016; 21(2): 104. CrossRef
- Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model
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Seok Joo Park, Yoon Hee Chung, Jeong Hyun Lee, Duy-Khanh Dang, Yunsung Nam, Ji Hoon Jeong, Yong Sun Kim, Toshitaka Nabeshima, Eun-Joo Shin, Hyoung-Chun Kim
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Endocrinol Metab. 2014;29(3):336-348. Published online September 25, 2014
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DOI: https://doi.org/10.3803/EnM.2014.29.3.336
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Abstract
PDFPubReader
- Background
It has been recognized that a defect in klotho gene expression accelerates the degeneration of multiple age-sensitive traits. Accumulating evidence indicates that aging is associated with declines in cognitive function and the activity of growth hormone (GH)/insulin-like growth factor-1 (IGF-1).
MethodsIn this study, we examined whether a GH-releaser diet could be effective in protecting against cognitive impairment in klotho mutant mice.
ResultsThe GH-releaser diet significantly induced the expression of IGF-1 and IGF-1 receptors in the hippocampus of klotho mutant mice. Klotho mutant mice showed significant memory impairments as compared with wild-type mice. In addition, the klotho mutation significantly decreased the expression of cell survival/antiapoptotic factors, including phospho-Akt (p-Akt)/phospho-glycogen synthase kinase3β (p-GSK3β), phospho-extracellular signal-related kinase (p-ERK), and Bcl-2, but significantly increased those of cell death/proapoptotic factors, such as phospho-c-jun N-terminal kinase (p-JNK), Bax, and cleaved caspase-3 in the hippocampus. Treatment with GH-releaser diet significantly attenuated both decreases in the expression of cell survival/antiapoptotic factors and increases in the expression of cell death/proapoptotic factors in the hippocampus of klotho mutant mice. In addition, klotho mutation-induced oxidative stress was significantly attenuated by the GH-releaser diet. Consequently, a GH-releaser diet significantly improved memory function in the klotho mutant mice. GH-releaser diet-mediated actions were significantly reversed by JB-1, an IGF-1 receptor antagonist.
ConclusionThe results suggest that a GH-releaser diet attenuates oxidative stress, proapoptotic changes and consequent dysfunction in klotho mutant mice by promoting IGF-1 expression and IGF-1 receptor activation.
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Citations
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- Virgin coconut oil reverses behavioral phenotypes of letrozole-model of PCOS in Wistar rats via modulation of NRF2 upregulation
Olabode O. Akintoye, Ayodeji J. Ajibare, Idowu O. Omotuyi
Journal of Taibah University Medical Sciences.2023; 18(4): 831. CrossRef - Nonlinear relationship between glycated hemoglobin and cognitive impairment after acute mild ischemic stroke
Lei Xu, Qin Xiong, Yang Du, Lu-wen Huang, Ming Yu
BMC Neurology.2023;[Epub] CrossRef - The location, physiology, pathology of hippocampus Melatonin MT2 receptor and MT2-selective modulators
Yueqin Feng, Xiaowen Jiang, Wenwu Liu, Hongyuan Lu
European Journal of Medicinal Chemistry.2023; 262: 115888. CrossRef - Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction
Thomas M. Barber, Ioannis Kyrou, Harpal S. Randeva, Martin O. Weickert
International Journal of Molecular Sciences.2021; 22(2): 546. CrossRef - A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans
Jie Tang, Jian-Fan Zhang, Rui-Qiu Yang, Yuan-Li Chen, Baosen Ni
Biochemical and Biophysical Research Communications.2021; 562: 36. CrossRef - Melatonin Receptor as a Drug Target for Neuroprotection
Pawaris Wongprayoon, Piyarat Govitrapong
Current Molecular Pharmacology.2020; 14(2): 150. CrossRef - Theanine attenuates memory impairments induced by klotho gene depletion in mice
Bao Trong Nguyen, Naveen Sharma, Eun-Joo Shin, Ji Hoon Jeong, Sung Hoon Lee, Choon-Gon Jang, Seung-Yeol Nah, Toshitaka Nabeshima, Yukio Yoneda, Hyoung-Chun Kim
Food & Function.2019; 10(1): 325. CrossRef - Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease
Rikki Hullinger, Luigi Puglielli
Behavioural Brain Research.2017; 322: 191. CrossRef - Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression
Anna Massó, Angela Sánchez, Lydia Gimenez-Llort, Jose Miguel Lizcano, Manuel Cañete, Belen García, Virginia Torres-Lista, Meritxell Puig, Assumpció Bosch, Miguel Chillon, David Blum
PLOS ONE.2015; 10(11): e0143623. CrossRef - Evaluation of individual aging degree by standard-free, label-free LC-MS/MS quantification of formaldehyde-modified peptides
Mei Zhang, Wei Xu, Ming Ke, Jianguo Xu, Yulin Deng
The Analyst.2015; 140(12): 4137. CrossRef - Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef - Insulin resistance and cognitive dysfunction
Lina Ma, Jieyu Wang, Yun Li
Clinica Chimica Acta.2015; 444: 18. CrossRef
- Accelerated and Exacerbated Effects of High Dietary Fat on Neuronal Damage Induced by Transient Cerebral Ischemia in the Gerbil Septum
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Seung Hwan Cheon, Bing Chun Yan, Bai Hui Chen, Joon Ha Park, Ji Hyeon Ahn, In Hye Kim, Jae-Chul Lee, Yoo Seok Park, Min Joung Kim, Yun Lyul Lee, Jun Hwi Cho, Moo-Ho Won
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Endocrinol Metab. 2014;29(3):328-335. Published online September 25, 2014
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DOI: https://doi.org/10.3803/EnM.2014.29.3.328
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3,523
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Abstract
PDFPubReader
- Background
Obesity induced by high-fat diet (HFD) is one of the most widespread metabolic disorders in current society. However, there has been little research regarding the effects of HFD-induced obesity in the septa of animal models of cerebral ischemia. Therefore, in the present study, we investigated septal effects of HFD on neuronal damage and gliosis induced by transient cerebral ischemia.
MethodsBody weight, blood glucose levels and serum lipid profiles levels were measured both in the normal diet (ND) and HFD-group. We also investigated the effects of ND and HFD on neuronal damage and gliosis in the septum after transient cerebral ischemia using immunohistochemistry.
ResultsThe levels of blood glucose, serum triglyceride, and total cholesterol were significantly increased in the HFD-fed gerbils compared with the ND-fed gerbils, although body weight was not significantly changed after HFD feeding. In the ND-fed gerbils, ischemia-induced neuronal damage was found in the septohippocampal nucleus (SHN) of the septum 7 days after ischemia. In the HFD-fed gerbils, ischemia-induced neuronal damage in the SHN was much more severe compared with that of the ND-fed gerbils 4 and 7 days after ischemia. In addition, we found that ischemia-induced glial activation including astrocytes and microglia was accelerated and exacerbated in the HFD-fed gerbils compared with that in the ND-fed gerbils.
ConclusionThese results indicate that HFD can lead to much more severe effects in ischemia-induced neuronal damage/death in the septum after ischemia-reperfusion, and that it may be associated with accelerated change in glial activation.
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Nuttapong Yawoot, Piyarat Govitrapong, Chainarong Tocharus, Jiraporn Tocharus
BioFactors.2021; 47(1): 41. CrossRef - Analysis of knowledge bases and research focuses of cerebral ischemia-reperfusion from the perspective of mapping knowledge domain
Yi Qin, Qing Zhang, Yaru Liu
Brain Research Bulletin.2020; 156: 15. CrossRef - High fat diet accelerates and exacerbates microgliosis and neuronal damage/death in the somatosensory cortex after transient forebrain ischemia in gerbils
Won Joo Seo, Ji Hyeon Ahn, Tae-Kyeong Lee, Bora Kim, Jae-Chul Lee, Joon Ha Park, Yeon Ho Yoo, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Yoonsoo Park
Laboratory Animal Research.2020;[Epub] CrossRef - A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated Oxidative Stress and Neuroinflammation
Joon Ha Park, Ji Hyeon Ahn, Minah Song, Hyunjung Kim, Cheol Woo Park, Young Eun Park, Tae-Kyeong Lee, Jae-Chul Lee, Dae Won Kim, Choong-Hyun Lee, In Koo Hwang, Bing Chun Yan, Sungwoo Ryoo, Young-Myeong Kim, Il Jun Kang, Moo-Ho Won, Soo Young Choi
Cells.2019; 8(10): 1126. CrossRef - Prolonged High Fat Diet Worsens the Cellular Response to a Small, Covert-like Ischemic Stroke
Kathleen E. Fifield, Todd M. Rowe, Joanna B. Raman-Nair, Michiru Hirasawa, Jacqueline L. Vanderluit
Neuroscience.2019; 406: 637. CrossRef - Antioxidant Properties of Fucoidan Alleviate Acceleration and Exacerbation of Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia in High-Fat Diet-Induced Obese Gerbils
Ji Ahn, Myoung Shin, Dae Kim, Hyunjung Kim, Minah Song, Tae-Kyeong Lee, Jae-Chul Lee, Hyeyoung Kim, Jun Cho, Young-Myeong Kim, Jong-Dai Kim, Soo Choi, Moo-Ho Won, Joon Park
International Journal of Molecular Sciences.2019; 20(3): 554. CrossRef - Obesity and stroke: Can we translate from rodents to patients?
Michael J Haley, Catherine B Lawrence
Journal of Cerebral Blood Flow & Metabolism.2016; 36(12): 2007. CrossRef - Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
Review Article
- Thyroid
- Low Iodine Diet for Preparation for Radioactive Iodine Therapy in Differentiated Thyroid Carcinoma in Korea
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Jae Hoon Chung
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Endocrinol Metab. 2013;28(3):157-163. Published online September 13, 2013
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DOI: https://doi.org/10.3803/EnM.2013.28.3.157
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Abstract
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Preparation for radioactive iodine (RAI) therapy includes an increased serum thyroid stimulating hormone level and a low iodine diet (LID). Because of extremely high iodine intake, some physicians have advocated a more stringent LID for greater than 2 weeks in Korean patients with thyroid cancer prior to RAI therapy; however, it is very difficult to maintain a stringent LID for a longer period of time. According to recent reports in Korea, a nonstringent, simple LID for only 1 week might be enough prior to RAI therapy, if the patients can be educated intensively by specially trained staff. The measurement of simple urinary iodine concentration (UIC; µg/L) may underestimate daily iodine excretion in patients with a urinary volume of more than 1 L/day and can also be affected by dilution status. Simple UIC had a weaker correlation than the iodine/creatinine (I/Cr) ratio. Therefore, the urinary I/Cr ratio can replace 24-hour urine iodine excretion instead of simple UIC, although it may overestimate iodine intake in patients with malnutrition or poor muscle mass. The measurement of serum iodine level might be useful as an adjunct parameter for assessing LID preparation, but its sensitivity and specificity were relatively low compared to the urinary I/Cr ratio.
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- Theranostics of Thyroid Cancer
Luca Giovanella, Murat Tuncel, Atena Aghaee, Alfredo Campenni, Armando De Virgilio, Petra Petranović Ovčariček
Seminars in Nuclear Medicine.2024;[Epub] CrossRef - Patient Preparation and Radiation Protection Guidance for Adult Patients Undergoing Radioiodine Treatment for Thyroid Cancer in the UK
J. Wadsley, N. Armstrong, V. Bassett-Smith, M. Beasley, R. Chandler, L. Cluny, A.J. Craig, K. Farnell, K. Garcez, N. Garnham, K. Graham, A. Hallam, S. Hill, H. Hobrough, F. McKiddie, M.W.J. Strachan
Clinical Oncology.2023; 35(1): 42. CrossRef - Nomogram Model Based on Iodine Nutrition and Clinical Characteristics of Papillary Thyroid Carcinoma to Predict Lateral Lymph Node Metastasis
Junrong Wang, Yuzhang Gao, Yuxuan Zong, Weitong Gao, Xueying Wang, Ji Sun, Susheng Miao
Cancer Control.2023;[Epub] CrossRef - Is a 4-Day Low-Iodine Diet Sufficient for Radioactive Iodine Ablation in Differentiated Thyroid Cancer Treatment?
Alex Tessnow
Clinical Thyroidology.2022; 34(3): 123. CrossRef - The Role of the Nurse in Patients on Low Iodine Diet Period
Nedıme KOSGEROGLU, Dilek GÜMÜŞ, Handan KOYUNCU
OSMANGAZİ JOURNAL OF MEDICINE.2022;[Epub] CrossRef - The Interplay Between Thyroid Dysfunction and Kidney Disease
Yoko Narasaki, Peter Sohn, Connie M. Rhee
Seminars in Nephrology.2021; 41(2): 133. CrossRef - Urinary iodine concentration and radioactive iodine therapeutic response in patients with differentiated thyroid cancer
Yuyan Jiang, Jiahui Jin, Jingzheng Fan, Chao Huang, Qiang Jia, Jian Tan, Xianghui He, Xiangqian Zheng, Yue Zhao, Qing Zhang, Zhaowei Meng, Yan Wang
Biomarkers in Medicine.2021; 15(11): 879. CrossRef - Update on Thyroid Hormone Levels and Thyroid Dysfunction in the Korean Population Based on Data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
Jae Hoon Chung
Endocrinology and Metabolism.2020; 35(1): 7. CrossRef - Contemporary considerations in adjuvant radioiodine treatment of adults with differentiated thyroid cancer
Malik E. Juweid, Mark Tulchinsky, Ayman Mismar, Munther Momani, Ayman A. Zayed, Hussam Al Hawari, Nader Albsoul, Felix M. Mottaghy
International Journal of Cancer.2020; 147(9): 2345. CrossRef - Personalized management of differentiated thyroid cancer in real life – practical guidance from a multidisciplinary panel of experts
Alfredo Campennì, Daniele Barbaro, Marco Guzzo, Francesca Capoccetti, Luca Giovanella
Endocrine.2020; 70(2): 280. CrossRef - Urinary iodine concentration and thyroid hormones: Korea National Health and Nutrition Examination Survey 2013–2015
Hye In Kim, Hyun-Kyung Oh, So Young Park, Hye Won Jang, Myung-Hee Shin, Sun Wook Kim, Tae Hyuk Kim, Jae Hoon Chung
European Journal of Nutrition.2019; 58(1): 233. CrossRef - Analysis of Iodine Content in Salts and Korean Sauces for Low-Iodine Diet Education in Korean Patients with Thyroid Cancer Preparing for Radioiodine Therapy
Soo Young Kim, Jung Mi Park, Jae Pil Hwang
Nuclear Medicine and Molecular Imaging.2018; 52(3): 229. CrossRef - Evaluation of Thyroid Hormone Levels and Urinary Iodine Concentrations in Koreans Based on the Data from Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
Jae Hoon Chung
Endocrinology and Metabolism.2018; 33(2): 160. CrossRef - The application of serum iodine in assessing individual iodine status
Xing Jin, Peng Jiang, Lixiang Liu, Qingzhen Jia, Peng Liu, Fangang Meng, Xiaoye Zhang, Yunfeng Guan, Yi Pang, Zheng Lu, Hongmei Shen
Clinical Endocrinology.2017; 87(6): 807. CrossRef - Dietary evaluation of a low-iodine diet in Korean thyroid cancer patients preparing for radioactive iodine therapy in an iodine-rich region
Dal Lae Ju, Young Joo Park, Hee-Young Paik, Min-Ji Kim, Seonyeong Park, Kyong Yeun Jung, Tae Hyuk Kim, Hun Sung Choi, Yoon Ju Song
Nutrition Research and Practice.2016; 10(2): 167. CrossRef - Experiences with a low-iodine diet: A qualitative study of patients with thyroid cancer receiving radioactive iodine therapy
Kyem Ju Lee, Sung Ok Chang, Kwang Yoon Jung
European Journal of Oncology Nursing.2016; 23: 43. CrossRef - The Impact of Low Adherence to the Low-iodine Diet on the Efficacy of the Radioactive Iodine Ablation Therapy
Dal Lae Ju, Young Joo Park, Hee-Young Paik, YoonJu Song
Clinical Nutrition Research.2015; 4(4): 267. CrossRef - Effect of Iodine Restriction on Thyroid Function in Subclinical Hypothyroid Patients in an Iodine-Replete Area: A Long Period Observation in a Large-Scale Cohort
Ji Young Joung, Yoon Young Cho, Sun-Mi Park, Tae Hun Kim, Na Kyung Kim, Seo Young Sohn, Sun Wook Kim, Jae Hoon Chung
Thyroid.2014; 24(9): 1361. CrossRef - Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
Won-Young Lee
Endocrinology and Metabolism.2014; 29(3): 251. CrossRef
Randomized Controlled Trial
- The Effect of Intensive Education on Glycemic Control in Type 2 Diabetic Patients.
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Youn Wook Lee, Won Sun Hwang, Sun Jung Choe, Dong Hun Lee, Doh Hyun Kim, Eun Hee Lee, Eun Gyoung Hong, Hye Lim Noh, Yoon Sok Chung, Kwan Woo Lee, Hyeon Man Kim
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J Korean Endocr Soc. 2003;18(1):63-72. Published online February 1, 2003
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Abstract
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- BACKGROUND
To this date, efforts to develop effective methods for the education of diabetic patients have been limited. The important goal of self-management and weight control for diabetic treatment can not be attained without long and intensive period of education. This study was undertaken to assess the effectiveness of an intensive educational program, of behavior and diet control, which was carried out on subjects with type 2 diabetes, on an out-patient basis. We compared the effectiveness of an intensive education programme with that of a conventional education programme for the self-management of type 2 diabetic patients. METHODS: Subjects with type 2 diabetes were randomly selected, and allocated to one of two groups. One group received a conventional education programme of self-management(the CE group), and the second group received an intensive education programmes for three months, after which the effectiveness of the programmes were evaluated. RESULTS: 1) The levels of fasting blood sugar(FBS), postprandial 2 hour blood sugar(PP2h) and HbA1c were significantly lowered in both groups following the intervention(p<0.05). In the IE group, the FBS declined from 12.4nmol/L to 7.7nmol/L, PP2h declined from 20.3nmol/L to 10.9nmol/L, and the HbA1c showed a similar decline from 9.4 to 7.0% after intervention(p<0.05). In the CE group, the FBS declined from 10.9 to 9.4nmol/l, the PP2h decreased from 17.1 to 14.6 nmol/l, and the HbA1c also decreased from 8.5 to 7.3% after intervention(p<0.05). The decrease in the FBS and HbA1c following the educational intervention was more pronounced in the IE group than the CE group (p<0.05). 2) The effectiveness of the education programmes in promoting appropriate dietary behavior in the diabetic subjects was assessed by a scoring system in three parts: a regularity score, a balance score and an attitude score. From a comparative study of the three scores, the patients attitudes were observed to be much improved in both the groups following the intervention compared to before the programmes, but the balance and total scores were significantly higher in the IE group than the CE group(p<0.05). CONCLUSION: We can conclude that the intensive diabetic education programme is more effective than a conventional programme, not only in improving the patients' levels of glucose, HbAlc, and dietary score, but also the diabetic patients self-control abilities, promoting behavioral change, and prompting problem solving capabilities in respect to the everyday problems that they have to face throughout their lives.
Original Articles
- Association Between Peak Bone Mass and Genetic Polymorphisms of the Vitamin D Receptor, Estrogen Receptor, and Type I Collagen 1 Genes in Healthy Young Korean Women.
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Hong Kyu Kim, Sang Wook Kim, Eun Sook Kim, Ghi Su Kim
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J Korean Endocr Soc. 2001;16(1):97-114. Published online February 1, 2001
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Abstract
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- BACKGROUND
Genetic suggest that strongest effect is observed in the premenopausal peak bone mass, which become less with age. However, the evaluation of candidate genes polymorphisms has been most frequently done in postmenopausal women and the results have been controversial. Therefore, we studied the possible association of the peak bone mass and candidate for osteoporosis genes polymorphism in premenopausal women. METHODS: The associations between BMD and polymorphisms of the vitamin D receptor (3'-end region by BsmI restriction enzyme and start codon by FokI restriction enzyme), estrogen receptor (by PvuII and XbaI restriction enzyme), and type I collagen 1 (Sp1 binding site by MscI and BalI restriction enzyme) genes were examined in 100 healthy young Korean women who had a peak bone mass (age 20-35 years). Bone mineral densities were measured by dual energy X-ray absorptiometry (DEXA). Dietary calcium intake was also measured using a food frequency questionnaire. RESULTS: The frequencies of the B allele of the vitamin D receptor gene BsmI polymorphism and the X allele in the estrogen receptor gene, XbaI polymorphisms were lower in Koreans than those in Caucasians. The allelic frequencies of the vitamin vitamin D receptor gene FokI polymorphism and the estrogen receptor gene PvuII polymorphism were similar to those of Caucasians. No significant association was found between BMD and the vitamin D receptor genotype according to BsmI or FokI polymorphisms. There was also no significant relation between the PvuII or XbaI polymorphisms of the estrogen receptor gene and BMD. The associations between BMD and cross-genotypes combining the vitamin D receptor gene (BsmI and FokI) and estrogen receptor gene (PvuII and XbaI) polymorphisms were also analyzed. Among the subjects who lacked the Bf haplotype of the vitamin D receptor gene, the BMD of the femoral neck area was significantly higher in subjects lacking Px haplotypes of the estrogen receptor gene than in those having Px haplotype (p < 0.05). When dietary calcium intake was taken into consideration, there were significant differences in BMD according to the cross-genotype in the group having a low calcium intake (< 500 mg/day). The subjects that lacked the Bf and Px haplotypes had a significantly higher BMD in the femoral neck (p < 0.01), Ward's triangle (p < 0.05), and in the trochanteric area (p < 0.05) than those who lacked Bf but a Px haplotype. We did not find a polymorphism in the Sp1 binding site of the type I collagen 1 gene in our subjects. CONCLUSION: These data suggest that a complex interaction of vitamin D and the estrogen receptor gene with the dietary calcium intake, rather than a polymorphism of a single gene, may influence peak bone mass in healthy young Korean women.
- Clinical Report of Effects of Pre and Post-partum Thyroiditis (PPT).
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Yong Wook Cho, Myung Seo Kang, Young Soo Cha, Jin Hwan Kook, Yoo Ri Kim, Pil Won Park, Wee Hyun Lee, Jung Eun Lim, Yo Won Cho
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J Korean Endocr Soc. 1997;12(4):541-549. Published online January 1, 2001
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Abstract
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- BACKGROUND
Excessive iodine intake increases the occurrence of autoimmune thyroid disorders by enhancing immunogenecity of iodine-rich thyroglobulin, In Korea, most of postpartum women take a large amount of iodine-rich seaweed. Although the excessive iodine intake may affect the thyroid function, only a few reports were available concering iodine intake, especially on postpartum period. METHODS: A prospective study was undertaken in 146 of normal delivered postpartum women. Dietary intake and urinary excretion of iodine, serum T3, T4, TSH, anti-TPO Ab and anti-Tg Ab were measured before and 1, 6, 12 and 24 weeks after delivery. Iodine intake was analyzed by one-to-one interview using 24hr recall and food frequency questionnaire. RESULTS: 1. PPT was occurred in 6 (10.3%) postparturn women, It presented as hypothyroidism alone in 1 (16.7%), transient thyrotoxicosis followed by hypothyroidisrn in 3 (50.0%), and thyrotoxicosis alone in 2 (33.3%) of the follwed-up patients. 2. During pregnancy, no difference was found in age, serum T3, T4 and TSH between PPT and normal thyroid function group. 3. In PPT group, anti-TPO and anti-Tg Ab were significantly higher than those of normal thyroid function group during pregnancy, and their sensitivity for PPT was 40% and 33%, respectively. But there was no correlation between dietary iodine intake and the titer of thyroid auto-antibodies. 4. There was no correlation between pre and post-partum dietary iodine intake and occurrence of PPT. CONCLUSION: In Korea, the incidence of PPT was slightly higher than other nations. The sensitivity of thyroid auto-antibodies was too low to use for prediction of PPT. Pre and post-partum iodine intake had no effect on the occurrence of PPT and post-partum thyroid function.