Fig. 1
BsmI and ApaI sites.
Table 1Clinical Characteristics of Patients of Type 2 Diabetes according to Bsm1 Genotype
Characteristic |
Total (n=537) |
BB+Bb (n=68) |
bb (n=469) |
P value |
Sex, female:male |
255:282 |
34:34 |
221:248 |
0.658 |
Age, yr |
62.44±10.64 |
59.19±10.58 |
62.93±10.59 |
0.007 |
BMI, kg/m2
|
25.02±3.64 |
23.73±4.19 |
25.20±3.52 |
0.002 |
Duration of DM, yr |
13.65±7.39 |
13.09±7.28 |
13.73±7.41 |
0.506 |
Fasting glucose, mg/dL |
145.98±55.89 |
151.59±76.96 |
145.16±52.20 |
0.376 |
PP2, mg/dL |
208.00±78.86 |
206.34±68.00 |
208.25±74.71 |
0.842 |
HbA1c, % |
7.58±1.41 |
7.85±1.74 |
7.54±1.36 |
0.088 |
C-peptide, ng/mL |
2.62±2.07 |
2.56±1.71 |
2.63±2.11 |
0.787 |
Cholesterol, mg/dL |
170.67±34.22 |
171.65±38.24 |
170.53±33.64 |
0.802 |
Triglyceride, mg/dL |
158.47±99.01 |
141.04±71.88 |
161.00±102.17 |
0.120 |
HDL-C, mg/dL |
45.63±11.87 |
47.88±11.73 |
45.30±11.87 |
0.094 |
LDL-C, mg/dL |
96.57±28.09 |
95.53±30.38 |
96.72±27.77 |
0.744 |
BUN, mg/dL |
16.42±8.32 |
15.08±5.90 |
16.62±8.60 |
0.154 |
Cr, mg/dL |
1.14±0.81 |
1.00±0.38 |
1.16±0.85 |
0.125 |
eGFR, mL/min/1.73 m2
|
77.12±26.37 |
82.23±27.05 |
76.38±26.22 |
0.087 |
uACR, µg/mgCr |
98.50±316.32 |
64.60±263.41 |
103.42±323.22 |
0.345 |
Family history of DM |
269 (50) |
32 (47) |
237 (51) |
0.593 |
Hypertension |
355 (66) |
41 (60) |
314 (67) |
0.279 |
Statin |
306 (57) |
40 (59) |
266 (57) |
0.743 |
Table 2Prevalence of Other Diabetic Microvascular/Macrovascular Complications according to Bsm1 Genotype
Variable |
BB+Bb |
bb |
P value |
ESRDa
|
0 |
4 (9) |
0.580 |
Polyneuropathyb
|
33 (48.5) |
233 (49.7) |
0.979 |
Strokec
|
5 (7.4) |
50 (10.7) |
0.273 |
MI |
4 (5.9) |
14 (3.0) |
0.183 |
PADd
|
0 |
6 (1.3) |
0.442 |
DM foot |
2 (2.9) |
18 (3.8) |
0.524 |
Table 3Distribution of Bsm1 Genotypes in Type 2 Diabetic Patients
|
No. (%) |
Total |
537 (100) |
BB |
10 (1.86) |
Bb |
58 (10.80) |
bb |
469 (87.34) |
Table 4Logistic Analysis of Multiple Risk Factors for the Association with Diabetic Retinopathy according to Bsm1 Genotype
Variable |
Severe NPDR, PDR |
OR (95% CI) |
P value |
Non-B allele |
2.63 (1.03-6.75) |
0.037 |
HbA1c |
2.87 (1.11-7.45) |
0.030 |
Body mass index |
3.23 (1.23-8.48) |
0.017 |
Sex |
3.20 (1.22-8.40) |
0.018 |
Age |
3.05 (1.16-8.03) |
0.024 |
DM duration |
2.86 (1.04-7.87) |
0.042 |
Dyslipidemia |
2.96 (1.08-8.13) |
0.035 |
Hypertension |
2.99 (1.08-8.29) |
0.035 |