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Volume 28(3); September 2013
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Review Articles
Thyroid
Low Iodine Diet for Preparation for Radioactive Iodine Therapy in Differentiated Thyroid Carcinoma in Korea
Jae Hoon Chung
Endocrinol Metab. 2013;28(3):157-163.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.157
  • 3,676 View
  • 38 Download
  • 19 Crossref
AbstractAbstract PDFPubReader   

Preparation for radioactive iodine (RAI) therapy includes an increased serum thyroid stimulating hormone level and a low iodine diet (LID). Because of extremely high iodine intake, some physicians have advocated a more stringent LID for greater than 2 weeks in Korean patients with thyroid cancer prior to RAI therapy; however, it is very difficult to maintain a stringent LID for a longer period of time. According to recent reports in Korea, a nonstringent, simple LID for only 1 week might be enough prior to RAI therapy, if the patients can be educated intensively by specially trained staff. The measurement of simple urinary iodine concentration (UIC; µg/L) may underestimate daily iodine excretion in patients with a urinary volume of more than 1 L/day and can also be affected by dilution status. Simple UIC had a weaker correlation than the iodine/creatinine (I/Cr) ratio. Therefore, the urinary I/Cr ratio can replace 24-hour urine iodine excretion instead of simple UIC, although it may overestimate iodine intake in patients with malnutrition or poor muscle mass. The measurement of serum iodine level might be useful as an adjunct parameter for assessing LID preparation, but its sensitivity and specificity were relatively low compared to the urinary I/Cr ratio.

Citations

Citations to this article as recorded by  
  • Theranostics of Thyroid Cancer
    Luca Giovanella, Murat Tuncel, Atena Aghaee, Alfredo Campenni, Armando De Virgilio, Petra Petranović Ovčariček
    Seminars in Nuclear Medicine.2024;[Epub]     CrossRef
  • Patient Preparation and Radiation Protection Guidance for Adult Patients Undergoing Radioiodine Treatment for Thyroid Cancer in the UK
    J. Wadsley, N. Armstrong, V. Bassett-Smith, M. Beasley, R. Chandler, L. Cluny, A.J. Craig, K. Farnell, K. Garcez, N. Garnham, K. Graham, A. Hallam, S. Hill, H. Hobrough, F. McKiddie, M.W.J. Strachan
    Clinical Oncology.2023; 35(1): 42.     CrossRef
  • Nomogram Model Based on Iodine Nutrition and Clinical Characteristics of Papillary Thyroid Carcinoma to Predict Lateral Lymph Node Metastasis
    Junrong Wang, Yuzhang Gao, Yuxuan Zong, Weitong Gao, Xueying Wang, Ji Sun, Susheng Miao
    Cancer Control.2023;[Epub]     CrossRef
  • Is a 4-Day Low-Iodine Diet Sufficient for Radioactive Iodine Ablation in Differentiated Thyroid Cancer Treatment?
    Alex Tessnow
    Clinical Thyroidology.2022; 34(3): 123.     CrossRef
  • The Role of the Nurse in Patients on Low Iodine Diet Period
    Nedıme KOSGEROGLU, Dilek GÜMÜŞ, Handan KOYUNCU
    OSMANGAZİ JOURNAL OF MEDICINE.2022;[Epub]     CrossRef
  • The Interplay Between Thyroid Dysfunction and Kidney Disease
    Yoko Narasaki, Peter Sohn, Connie M. Rhee
    Seminars in Nephrology.2021; 41(2): 133.     CrossRef
  • Urinary iodine concentration and radioactive iodine therapeutic response in patients with differentiated thyroid cancer
    Yuyan Jiang, Jiahui Jin, Jingzheng Fan, Chao Huang, Qiang Jia, Jian Tan, Xianghui He, Xiangqian Zheng, Yue Zhao, Qing Zhang, Zhaowei Meng, Yan Wang
    Biomarkers in Medicine.2021; 15(11): 879.     CrossRef
  • Update on Thyroid Hormone Levels and Thyroid Dysfunction in the Korean Population Based on Data from the Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
    Jae Hoon Chung
    Endocrinology and Metabolism.2020; 35(1): 7.     CrossRef
  • Contemporary considerations in adjuvant radioiodine treatment of adults with differentiated thyroid cancer
    Malik E. Juweid, Mark Tulchinsky, Ayman Mismar, Munther Momani, Ayman A. Zayed, Hussam Al Hawari, Nader Albsoul, Felix M. Mottaghy
    International Journal of Cancer.2020; 147(9): 2345.     CrossRef
  • Personalized management of differentiated thyroid cancer in real life – practical guidance from a multidisciplinary panel of experts
    Alfredo Campennì, Daniele Barbaro, Marco Guzzo, Francesca Capoccetti, Luca Giovanella
    Endocrine.2020; 70(2): 280.     CrossRef
  • Urinary iodine concentration and thyroid hormones: Korea National Health and Nutrition Examination Survey 2013–2015
    Hye In Kim, Hyun-Kyung Oh, So Young Park, Hye Won Jang, Myung-Hee Shin, Sun Wook Kim, Tae Hyuk Kim, Jae Hoon Chung
    European Journal of Nutrition.2019; 58(1): 233.     CrossRef
  • Analysis of Iodine Content in Salts and Korean Sauces for Low-Iodine Diet Education in Korean Patients with Thyroid Cancer Preparing for Radioiodine Therapy
    Soo Young Kim, Jung Mi Park, Jae Pil Hwang
    Nuclear Medicine and Molecular Imaging.2018; 52(3): 229.     CrossRef
  • Evaluation of Thyroid Hormone Levels and Urinary Iodine Concentrations in Koreans Based on the Data from Korea National Health and Nutrition Examination Survey VI (2013 to 2015)
    Jae Hoon Chung
    Endocrinology and Metabolism.2018; 33(2): 160.     CrossRef
  • The application of serum iodine in assessing individual iodine status
    Xing Jin, Peng Jiang, Lixiang Liu, Qingzhen Jia, Peng Liu, Fangang Meng, Xiaoye Zhang, Yunfeng Guan, Yi Pang, Zheng Lu, Hongmei Shen
    Clinical Endocrinology.2017; 87(6): 807.     CrossRef
  • Dietary evaluation of a low-iodine diet in Korean thyroid cancer patients preparing for radioactive iodine therapy in an iodine-rich region
    Dal Lae Ju, Young Joo Park, Hee-Young Paik, Min-Ji Kim, Seonyeong Park, Kyong Yeun Jung, Tae Hyuk Kim, Hun Sung Choi, Yoon Ju Song
    Nutrition Research and Practice.2016; 10(2): 167.     CrossRef
  • Experiences with a low-iodine diet: A qualitative study of patients with thyroid cancer receiving radioactive iodine therapy
    Kyem Ju Lee, Sung Ok Chang, Kwang Yoon Jung
    European Journal of Oncology Nursing.2016; 23: 43.     CrossRef
  • The Impact of Low Adherence to the Low-iodine Diet on the Efficacy of the Radioactive Iodine Ablation Therapy
    Dal Lae Ju, Young Joo Park, Hee-Young Paik, YoonJu Song
    Clinical Nutrition Research.2015; 4(4): 267.     CrossRef
  • Effect of Iodine Restriction on Thyroid Function in Subclinical Hypothyroid Patients in an Iodine-Replete Area: A Long Period Observation in a Large-Scale Cohort
    Ji Young Joung, Yoon Young Cho, Sun-Mi Park, Tae Hun Kim, Na Kyung Kim, Seo Young Sohn, Sun Wook Kim, Jae Hoon Chung
    Thyroid.2014; 24(9): 1361.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
Close layer
Adrenal gland
Characteristics of Acromegaly in Korea with a Literature Review
Jae Won Hong, Cheol Ryong Ku, Sun Ho Kim, Eun Jig Lee
Endocrinol Metab. 2013;28(3):164-168.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.164
  • 3,631 View
  • 50 Download
  • 12 Crossref
AbstractAbstract PDFPubReader   

Acromegaly is a slowly progressive disease caused by excessive growth hormone (GH), which is related to a GH secreting pituitary tumor in most cases. Herein, we describe the epidemiology, clinical characteristics, and treatment of acromegaly in Korea with a literature review. The average annual incidence of acromegaly in Korea was 3.9 cases per million people, which was within the range of previous Western studies. The primary treatment for acromegaly was also transsphenoidal adenomectomy, which accounted for 90.4% of patients whose primary therapeutic options were known. The overall surgical remission rates were 89%, 87%, 64%, 70%, and 50% for modified Hardy classification I, II, IIIA, IIIB, and IV, respectively. An updated and larger study regarding the treatment outcome of medical/radiotherapy in Korean acromegalic patients is needed.

Citations

Citations to this article as recorded by  
  • Risk of depression in patients with acromegaly in Korea (2006-2016): a nationwide population-based study
    Shinje Moon, Sangmo Hong, Kyungdo Han, Cheol-Young Park
    European Journal of Endocrinology.2023; 189(3): 363.     CrossRef
  • Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea
    Jiwon Kim, Namki Hong, Jimi Choi, Ju Hyung Moon, Eui Hyun Kim, Eun Jig Lee, Sin Gon Kim, Cheol Ryong Ku
    Endocrinology and Metabolism.2023; 38(6): 690.     CrossRef
  • Selective screening of patients with associated somatic diseases as a method of early detection of acromegaly
    M. B. Antsiferov, V. S. Pronin, T. M. Alekseeva, O. A. Ionova, E. Y. Martynova, Yu. E. Poteshkin, N. A. Chubrova, K. Y. Zherebchikova
    Problems of Endocrinology.2021; 67(1): 20.     CrossRef
  • Precision Therapy in Acromegaly Caused by Pituitary Tumors: How Close Is It to Reality?
    Cheol Ryong Ku, Vladimir Melnikov, Zhaoyun Zhang, Eun Jig Lee
    Endocrinology and Metabolism.2020; 35(2): 206.     CrossRef
  • Patient Characteristics, Diagnostic Delays, Treatment Patterns, Treatment Outcomes, Comorbidities, and Treatment Costs of Acromegaly in China: A Nationwide Study
    Xiaopeng Guo, Kailu Wang, Siyue Yu, Lu Gao, Zihao Wang, Huijuan Zhu, Bing Xing, Shuyang Zhang, Dong Dong
    Frontiers in Endocrinology.2020;[Epub]     CrossRef
  • Epidemiología de la acromegalia en Ecuador
    Enrique López Gavilanez, Kempis Guerrero Franco, Narcisa Solórzano Zambrano, Manuel Navarro Chávez, Camilo López Estrella, Luis Vaca Burbano, Eduardo Marriott Díaz
    Endocrinología y Nutrición.2016; 63(7): 333.     CrossRef
  • A magnetic resonance imaging‐based classification system for indication of trans‐sphenoidal hypophysectomy in canine pituitary‐dependent hypercortisolism
    A. Sato, T. Teshima, H. Ishino, Y. Harada, T. Yogo, N. Kanno, D. Hasegawa, Y. Hara
    Journal of Small Animal Practice.2016; 57(5): 240.     CrossRef
  • Epidemiology of acromegaly in Ecuador
    Enrique López Gavilanez, Kempis Guerrero Franco, Narcisa Solórzano Zambrano, Manuel Navarro Chávez, Camilo López Estrella, Luis Vaca Burbano, Eduardo Marriott Díaz
    Endocrinología y Nutrición (English Edition).2016; 63(7): 333.     CrossRef
  • An Association Study Between Gene Polymorphisms of Folic Acid Metabolism Enzymes and Biochemical and Hormonal Parameters in Acromegaly
    Aslı Tetik Vardarlı, Ayhan Zengi, Vildan Bozok Çetintaş, Muammer Karadeniz, Sadık Tamsel, Ali Şahin Küçükaslan, Timur Köse, Füsun Saygılı, Zuhal Eroglu
    Genetic Testing and Molecular Biomarkers.2015; 19(8): 431.     CrossRef
  • Diagnosis, treatment and clinical perspectives of acromegaly
    Ferdinand Roelfsema, Gerrit van den Berg
    Expert Review of Endocrinology & Metabolism.2015; 10(6): 619.     CrossRef
  • Change in quality of life in patients with acromegaly after treatment with octreotide LAR: first application of AcroQoL in Korea
    S. O. Chin, C. H. Chung, Y.-S. Chung, B.-J. Kim, H. Y. Kim, I.-J. Kim, J. G. Kim, M.-S. Kim, S.-Y. Kim, E. J. Lee, K. Y. Lee, S.-W. Kim
    BMJ Open.2015; 5(6): e006898.     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
Close layer
Obesity and Metabolism
High Density Lipoprotein: A Therapeutic Target in Type 2 Diabetes
Philip J. Barter
Endocrinol Metab. 2013;28(3):169-177.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.169
  • 3,702 View
  • 32 Download
  • 25 Crossref
AbstractAbstract PDFPubReader   

High density lipoproteins (HDLs) have a number of properties that have the potential to inhibit the development of atherosclerosis and thus reduce the risk of having a cardiovascular event. These protective effects of HDLs may be reduced in patients with type 2 diabetes, a condition in which the concentration of HDL cholesterol is frequently low. In addition to their potential cardioprotective properties, HDLs also increase the uptake of glucose by skeletal muscle and stimulate the synthesis and secretion of insulin from pancreatic β cells and may thus have a beneficial effect on glycemic control. This raises the possibility that a low HDL concentration in type 2 diabetes may contribute to a worsening of diabetic control. Thus, there is a double case for targeting HDLs in patients with type 2 diabetes: to reduce cardiovascular risk and also to improve glycemic control. Approaches to raising HDL levels include lifestyle factors such as weight reduction, increased physical activity and stopping smoking. There is an ongoing search for HDL-raising drugs as agents to use in patients with type 2 diabetes in whom the HDL level remains low despite lifestyle interventions.

Citations

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    Zhaoqi Yan, Yifeng Xu, Keke Li, Liangji Liu
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
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Close layer
Editorial
Thyroid
The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma
Bo Hyun Kim
Endocrinol Metab. 2013;28(3):178-179.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.178
  • 3,088 View
  • 31 Download
  • 8 Crossref
PDFPubReader   

Citations

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    Frontiers in Immunology.2024;[Epub]     CrossRef
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Close layer
Original Articles
Bone Metabolism
Age-Related Changes in the Prevalence of Osteoporosis according to Gender and Skeletal Site: The Korea National Health and Nutrition Examination Survey 2008-2010
Jongseok Lee, Sungwha Lee, Sungok Jang, Ohk Hyun Ryu
Endocrinol Metab. 2013;28(3):180-191.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.180
  • 5,133 View
  • 76 Download
  • 56 Crossref
AbstractAbstract PDFPubReader   
Background

The incidence of osteoporosis and its related fractures are expected to increase significantly in the rapidly aging Korean population. Reliable data on the prevalence of this disease is essential for treatment planning. However, sparse data on Korean patients is available.

Methods

We analyzed data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008 to 2010. Bone mineral density (BMD) was measured at the femoral neck and lumbar spine using dual-energy X-ray absorptiometry. Osteopenia and osteoporosis were diagnosed according to the World Health Organization T-score criteria. We analyzed the BMD data of 17,208 people (men, 7,837; women, 9,368).

Results

The adjusted prevalence of osteoporosis was 7.8% in men versus 37.0% in women. No significant difference was observed in the prevalence of osteopenia between genders (men, 47.0%; women, 48.7%). The prevalence of osteoporosis in men in their 50s was 4.0%, in their 60s was 7.2%, in their 70s was 15.1%, and in their 80s was 26.7%. The figures in women were 15.2%, 36.5%, 62.7%, and 85.8%, respectively. The age group with the maximal BMD differed between genders. In the men, 20s had the highest value in all the skeletal sites. However, in the women, the maximal BMD in the femoral neck, lumbar spine, and the total hip was observed in their 20s, 30s, and 40s, respectively. The onset age of osteoporosis differed between genders. Osteoporosis in the femoral neck began at 55 years in the women and at 60 years in the men.

Conclusion

The prevalence of osteoporosis in Korea was significantly high. In addition, the age-related changes in the prevalence of osteoporosis differed according to gender and skeletal site.

Citations

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Close layer
Thyroid
The Expression of Tumor-Associated Macrophages in Papillary Thyroid Carcinoma
Seunghwan Kim, Sun Wook Cho, Hye Sook Min, Kang Min Kim, Gye Jeong Yeom, Eun Young Kim, Kyu Eun Lee, Yeo Gyu Yun, Do Joon Park, Young Joo Park
Endocrinol Metab. 2013;28(3):192-198.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.192
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AbstractAbstract PDFPubReader   
Background

Tumor-associated macrophages (TAMs) play a tumorigenic role related to advanced staging and poor prognosis in many human cancers including thyroid cancers. Yet, a functional role of TAMs in papillary thyroid carcinoma (PTC) has not been established. The aim of this study was to investigate TAM expression in human PTC with lymph node (LN) metastasis.

Methods

Thirty-six patients who underwent surgery after being diagnosed with PTC with LN metastasis were included. Primary tumor tissues were immunohistochemically stained with an anti-CD68 antibody and clinical characteristics according to TAM density were evaluated.

Results

The TAM densities (CD68+ cells) varied from 5% to 70%, in all tumor areas, while few cells were stained in adjacent normal tissues. TAMs were identified as CD68+ cells with thin, elongated cytoplasmic extensions that formed a canopy structure over tumor cells. Comparing clinicopathologic characteristics between tumors with low (<25%) and high (25% to 70%) TAM densities, primary tumors were larger in the high density group than in the low density group (2.0±0.1 vs. 1.5±0.1; P=0.009).

Conclusion

TAMs were identified in primary PTC tumors with LN metastasis and higher TAM densities were related to larger tumor sizes, suggesting a tumorigenic role of TAMs in human PTCs.

Citations

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    Manal A. Badawi, Dalia M. Abouelfadl, Sonia L. El-Sharkawy, Wafaa E. Abd El-Aal, Naglaa F. Abbas
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Close layer
Obesity and Metabolism
The Impact of Different Anthropometric Measures on Sustained Normotension, White Coat Hypertension, Masked Hypertension, and Sustained Hypertension in Patients with Type 2 Diabetes
Baris Afsar
Endocrinol Metab. 2013;28(3):199-206.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.199
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AbstractAbstract PDFPubReader   
Background

Many studies have aimed to determine whether body mass index (BMI), waist circumference (WC), or waist to hip ratio (WHR) best predicts hypertension in diabetic patients, with conflicting results. However, no study has examined the specific relationship between these anthropometric parameters with sustained normotension (SNT), white coat hypertension (WCHT), masked hypertension (MHT), and sustained hypertension (SHT) based on office and ambulatory blood pressure (BP) measurements in these patients.

Methods

Patients with newly diagnosed type 2 diabetes underwent the following procedures: history taking, measurements of anthropometric parameters, office and ambulatory BP measurements, physical examination, laboratory analysis, and random and 24-hour urine analysis.

Results

In total, there were 65 dippers and 37 nondipper patients. None of the anthropometric parameters were different between the dippers and the nondippers. There were 25 patients with SNT, 32 with WCHT, seven with MHT, and 38 with SHT. A comparison of anthropometric parameters between these four groups of patients showed that WC (P=0.016) and WHR (P=0.015) were different among all groups. According to regression analysis, only BMI was independently related with MHT (odds ratio [OR], 1.373, P=0.022), whereas only WC has been associated with SHT (OR, 1.321, P=0.041).

Conclusion

Among anthropometric parameters, only WC and WHR were different in SNT, WCHT, MHT, and SHT in newly diagnosed patients with type 2 diabetes.

Citations

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Close layer
Obesity and Metabolism
Variation in Serum Creatinine Level Is Correlated to Risk of Type 2 Diabetes
Jun Sung Moon, Ji Eun Lee, Ji Sung Yoon
Endocrinol Metab. 2013;28(3):207-213.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.207
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  • 19 Crossref
AbstractAbstract PDFPubReader   
Background

Skeletal muscle is well established as a major target organ of insulin action, and is associated with the pathogenesis of type 2 diabetes. Therefore, we attempted to determine whether a variation in serum creatinine is related to the development of type 2 diabetes and other risk factors for diabetes.

Methods

A total of 2,676 nondiabetic subjects with stable and normal renal function (estimated glomerular filtration rate >60 mL/min/1.73 m2) were followed up for approximately 4.5 years. New onset diabetes was defined as fasting plasma glucose (FPG) ≥7.0 mmol/L, glycated hemoglobin (HbA1c) ≥6.5%, or subjects taking antidiabetic agents. Variation of serum creatinine (ΔCre) was defined as a difference between follow-up and baseline creatinine. In subgroup analysis, body composition was examined by bioelectric impedance analysis method.

Results

A total of 106 subjects were diagnosed with new-onset diabetes during the follow-up period. Baseline serum creatinine was not different between the new-onset diabetes and no diabetes groups. Negative ΔCre (ΔCre <0) showed an association with increased risk of type 2 diabetes after adjusting for age, sex, body mass index, systolic blood pressure, FPG, HbA1c, triglyceride, high density lipoprotein cholesterol, and γ-glutamyl transpeptidase (odds ratio, 1.885; 95% confidence interval, 1.127 to 3.153). Serum creatinine level demonstrated positive correlation with muscle mass and negative correlation with percentage of body fat in body composition analysis.

Conclusion

Serum creatinine reflected body muscle mass and the decrease of serum creatinine might be regarded as a risk factor for type 2 diabetes.

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    International Journal of General Medicine.2022; Volume 15: 777.     CrossRef
  • Ameliorative Effect of Oxytocin on FBN1 and PEPCK Gene Expression, and Behavioral Patterns in Rats' Obesity-Induced Diabetes
    Asmaa Elnagar, Khalifa El-Dawy, Hussein I. El-Belbasi, Ibrahim F. Rehan, Hamdy Embark, Zeinab Al-Amgad, Obeid Shanab, Elsayed Mickdam, Gaber E. Batiha, Salman Alamery, Samer S. Fouad, Simona Cavalu, Mohammed Youssef
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    Carlos A. Amado Diago, José A. Amado Señaris
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    Carlos A. Amado Diago, José A. Amado Señaris
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Close layer
Adrenal gland
Herpes Virus Entry Mediator Signaling in the Brain Is Imperative in Acute Inflammation-Induced Anorexia and Body Weight Loss
Kwang Kon Kim, Sung Ho Jin, Byung Ju Lee
Endocrinol Metab. 2013;28(3):214-220.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.214
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  • 30 Download
  • 11 Crossref
AbstractAbstract PDFPubReader   
Background

Reduced appetite and body weight loss are typical symptoms of inflammatory diseases. A number of inflammatory stimuli are responsible for the imbalance in energy homeostasis, leading to metabolic disorders. The herpes virus entry mediator (HVEM) protein plays an important role in the development of various inflammatory diseases, such as intestinal inflammation and diet-induced obesity. However, the role of HVEM in the brain is largely unknown. This study aims to investigate whether HVEM signaling in the brain is involved in inflammation-induced anorexia and body weight loss.

Methods

Food intake and body weight were measured at 24 hours after intraperitoneal injection of lipopolysaccharide (LPS) or intracerebroventricular injection of recombinant mouse LIGHT (also called tumor necrosis factor receptor superfamily 14, TNFSF14), an HVEM ligand, into 8- to 10-week-old male C57BL/6 mice and mice lacking HVEM expression (HVEM-/-). We also assessed LPS-induced change in hypothalamic expression of HVEM using immunohistochemistry.

Results

Administration of LPS significantly reduced food intake and body weight, and moreover, increased expression of HVEM in the hypothalamic arcuate nucleus. However, LPS induced only minor decreases in food intake and body weight in HVEM-/- mice. Administration of LIGHT into the brain was very effective at decreasing food intake and body weight in wild-type mice, but was less effective in HVEM-/- mice.

Conclusion

Activation of brain HVEM signaling is responsible for inflammation-induced anorexia and body weight loss.

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Close layer
Case Reports
Thyroid
Thyroid Dysfunction Associated with Administration of the Long-Acting Gonadotropin-Releasing Hormone Agonist
Eun Jin Han, Ha Do Song, Ji Hoon Yang, So Young Park, Sung Hoon Kim, Hyun Koo Yoon, Chang Hoon Yim
Endocrinol Metab. 2013;28(3):221-225.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.221
  • 4,427 View
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AbstractAbstract PDFPubReader   

Gonadotropin-releasing hormone (GnRH) agonist has been used in the treatment of a wide variety of sex-hormone-related diseases, as the administration of GnRH agonist can alter the secretion of gonadotropin and sex hormones. Recently, we found that the long-acting GnRH agonist aggravated hyperthyroidism and induced painless thyroiditis. This is the first report to demonstrate the association of thyroid dysfunction with GnRH agonist injection in Korea. Here, we report three cases and emphasize the clinical importance of this aggravating factor in autoimmune thyroid disease.

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  • Thyroid Dysfunction after Gonadotropin-Releasing Hormone Agonist Administration in Women with Thyroid Autoimmunity
    Loris Marin, Guido Ambrosini, Marco Noventa, Flavia Filippi, Eugenio Ragazzi, Francesco Dessole, Giampiero Capobianco, Alessandra Andrisani, Alexander Schreiber
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    Eunyoung Ha, Seungmee Lee, So Min Lee, Jeeyeon Jung, Hyewon Chung, Eunsom Choi, Sun Young Kwon, Min Ho Cha, So-Jin Shin
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    Yuan-Jie Du, Xin Xin, Na Cui, Lei Jiang, Ai-Min Yang, Gui-Min Hao, Bu-Lang Gao
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Close layer
Thyroid
Graves' Disease that Developed Shortly after Surgery for Thyroid Cancer
Hea Min Yu, Soon Hyun Park, Jae Min Lee, Kang Seo Park
Endocrinol Metab. 2013;28(3):226-230.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.226
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AbstractAbstract PDFPubReader   

Graves' disease is an autoimmune disorder that may present with various clinical manifestations of hyperthyroidism. Patients with Graves' disease have a greater number of thyroid nodules and a higher incidence of thyroid cancer compared with patients with normal thyroid activity. However, cases in which patients are diagnosed with recurrence of Graves' disease shortly after partial thyroidectomy for thyroid cancer are very rare. Here we report a case of hyperthyroid Graves' disease that occurred after partial thyroidectomy for papillary thyroid cancer. In this case, the patient developed hyperthyroidism 9 months after right hemithyroidectomy, and antithyroglobulin autoantibody and thyroid stimulating hormone receptor stimulating autoantibody were positive. Therefore, we diagnosed Graves' disease on the basis of the laboratory test results and thyroid ultrasonography findings. The patient was treated with and maintained on antithyroid drugs. The mechanism of the recurrence of Graves' disease in this patient is still unclear. The mechanism may have been the improper response of the immune system after partial thyroidectomy. To precisely determine the mechanisms in Graves' disease after partial thyroidectomy, further studies based on a greater number of cases are needed.

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Close layer
Thyroid
Delayed Surgery for Parathyroid Adenoma Misdiagnosed as a Thyroid Nodule and Treated with Radiofrequency Ablation
Ho-Su Kim, Bong Hoi Choi, Jung Rang Park, Jong Ryeal Hahm, Jung Hwa Jung, Soo Kyoung Kim, Sungsu Kim, Kyong-Young Kim, Soon Il Chung, Tae Sik Jung
Endocrinol Metab. 2013;28(3):231-235.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.231
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  • 10 Crossref
AbstractAbstract PDFPubReader   

Primary hyperparathyroidism occurs as a result of isolated parathyroid adenoma in 80% to 85% of all cases. A 99mtechnetium (99mTc) sestamibi scan or neck ultrasonography is used to localize the neoplasm prior to surgical intervention. A 53-year-old female was referred for the exclusion of metabolic bone disease. She presented with low back pain that had persisted for the past 6 months and elevated serum alkaline phosphatase (1,253 IU/L). Four years previously, she had been diagnosed at a local hospital with a 2.3-cm thyroid nodule, which was determined to be pathologically benign. Radiofrequency ablation was performed at the same hospital because the nodule was still growing during the follow-up period 2 years before the visit to our hospital, and the procedure was unsuccessful in reducing the size of the nodule. The results of the laboratory tests in our hospital were as follows: serum calcium, 14.6 mg/dL; phosphorus, 3.5 mg/dL; and intact parathyroid hormone (iPTH), 1,911 pg/mL. Neck ultrasonography and 99mTc sestamibi scan detected a 5-cm parathyroid neoplasm in the left lower lobe of the patient's thyroid; left parathyroidectomy was performed. This case indicated that thyroid ultrasonographers and pathologists need to be experienced enough to differentiate a parathyroid neoplasm from a thyroid nodule; 99mTc sestamibi scan, serum calcium, and iPTH levels can help to establish the diagnosis of parathyroid neoplasm.

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  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
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Polyglandular Autoimmune Syndrome Type III with Primary Hypoparathyroidism
Sang Jin Kim, Sang-Yoon Kim, Han-Byul Kim, Hyukwon Chang, Ho-Chan Cho
Endocrinol Metab. 2013;28(3):236-240.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.236
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Polyglandular autoimmune syndrome is defined as multiple endocrine gland insufficiencies accompanied by autoimmune diseases of the endocrine and nonendocrine system. After Schmidt introduced a case of nontuberculosis adrenal gland dysfunction with thyroiditis in 1926, Neufeld defined polyglandular autoimmune syndrome by I, II, and III subtypes in 1980 by their presentation of occurrence age, heredity methods, relationship with human leukocyte antigen, and accompanying diseases. We report a case of a 32-year-old female with polyglandular autoimmune syndrome III accompanied by type 1 diabetes mellitus that was treated with insulin (36 units per day) for 11 years. She had insulin deficiency and Hashimoto thyroiditis as an autoimmune disorder. In addition, she had several features similar to Albright's hereditary osteodystrophy including short stature, truncal obesity, round face, short neck, low intelligence (full IQ 84), and decreased memory. Although Albright's hereditary osteodystrophy is morphological evidence of pseudohypoparathyroidism or pseudopseudohypoparathyroidism, she had primary hypoparathyroidism on laboratory results. Here, we report a case of polyglandular autoimmune syndrome III with type 1 diabetes mellitus, autoimmune thyroiditis, and primary hypoparathyroidism, accompanied by clinical features similar to Albright's hereditary osteodystrophy.

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  • Autoimmune polyglandular syndrome type III associated with antineutrophil cytoplasmic autoantibody-mediated crescentic glomerulonephritis
    Shiyuan Tian, Baofeng Xu, Ziwei Liu, Rui Liu
    Medicine.2020; 99(7): e19179.     CrossRef
  • Hypoparathyroidism: Genetics and Diagnosis
    Michael Mannstadt, Luisella Cianferotti, Rachel I Gafni, Francesca Giusti, Elizabeth Helen Kemp, Christian A Koch, Kelly L Roszko, Liam Yao, Gordon H Guyatt, Rajesh V Thakker, Weibo Xia, Maria-Luisa Brandi
    Journal of Bone and Mineral Research.2020; 37(12): 2615.     CrossRef
  • A rare case of polyglandular autoimmune syndrome type IIIc with primary antibody failure
    Adina Elena Stanciu, Florentina Sava, Gergely Toldi
    Gynecological Endocrinology.2018; 34(4): 283.     CrossRef
  • Autoimmune Polyendocrine Syndrome Type IIIC and Ankylosing Spondylitis; a Case Report
    Ali Javinani, Hamid Reza Aghaei Meybodi, Ahmad Reza Jamshidi, Farhad Gharibdoost, Hoda Kavosi
    Rheumatology Research.2016;[Epub]     CrossRef
  • Brief Review of Articles in 'Endocrinology and Metabolism' in 2013
    Won-Young Lee
    Endocrinology and Metabolism.2014; 29(3): 251.     CrossRef
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Response
Thyroid
Response: Natural Course of Cytologically Benign Thyroid Nodules: Observation of Ultrasonographic Changes (Endocrinol Metab 2013;28:110-8, Dong Jun Lim et al.)
Dong Jun Lim, Ki Hyun Baek
Endocrinol Metab. 2013;28(3):243-244.   Published online September 13, 2013
DOI: https://doi.org/10.3803/EnM.2013.28.3.243
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  • 23 Download
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Citations

Citations to this article as recorded by  
  • Calcification Patterns in Papillary Thyroid Carcinoma are Associated with Changes in Thyroid Hormones and Coronary Artery Calcification
    Jeonghoon Ha, Jeongmin Lee, Kwanhoon Jo, Jeong-Sun Han, Min-Hee Kim, Chan Jung, Moo Kang, Bong Cha, Dong-Jun Lim
    Journal of Clinical Medicine.2018; 7(8): 183.     CrossRef
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