Yoga originated in India more than 5,000 years ago and is a means of balancing and harmonizing the body, mind, and emotions. Yoga practice is useful in the management of various lifestyle diseases, including type 2 diabetes. Psycho-neuro-endocrine and immune mechanisms are involved in the beneficial effects of yoga on diabetes. Incorporation of yoga practice in daily life helps to attain glycaemic control and reduces the risk of complications in people with diabetes. In this review, we briefly describe the role of various yoga practices in the management of diabetes based on evidence from various clinical studies.

Citations

Citations to this article as recorded by  

• Investigating Ayurvedic Strategies: An In-Depth Examination of Managing Diabetes across Different Types
  Acharya Balkrishna, Prashant Katiyar, Jaya Upreti, Muskan Chauhan, Dushyant Sharma, Sandeep Kumar, Vedpriya Arya
  Current Diabetes Reviews.2025;[Epub]     CrossRef
• Efficacy of integrated Ayurveda treatment protocol in uncontrolled type 2 diabetes mellitus: A randomized controlled study
  Suketha Kumari, Rekha Patil, Basavaraj R Tubaki
  European Journal of Integrative Medicine.2025; 73: 102424.     CrossRef
• Yoga practice can reduce metabolic syndrome and cardiovascular risk in climacteric women
  Laura Alves Cota e Souza, Thiago Magalhães Gouvea, Francielle Caroline Fernandes, Maria Ruth Gonçalves Gaede Carrillo, Vanja Maria Veloso, Ariosvaldo Figueiredo Santos Filho, Angélica Alves Lima
  Journal of Behavioral Medicine.2024; 47(1): 94.     CrossRef
• Clinical Practice Guidelines for mental health and well-being in patients with chronic medical illnesses
  Sandeep Grover, Ajit Avasthi, Abdul Majid
  Indian Journal of Psychiatry.2024; 66(Suppl 2): S338.     CrossRef
• Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
  Shradha S Parsekar, Nachiket Gudi, Sujata Chodankar Walke, Prabhu Dutta Shaw, Aditi Hombali, Anupama V Nayak, Basavaraj S Hadapad
  F1000Research.2024; 11: 526.     CrossRef
• CLINICAL STUDY OF YOGASANA AND PATHYAAHARA IN MANAGEMENT OF MADHUMEHA (DIABETES MELLITUS-2)
  Jyoti Prajapati, Pramod Kumar Mishra, Brahmanand Sharma
  International Ayurvedic Medical Journal.2024; 12(02): 346.     CrossRef
• Therapeutic role of yoga in hypertension
  Anjali Mangesh Joshi, Arkiath Veettil Raveendran, Muruganathan Arumugam
  World Journal of Methodology.2024;[Epub]     CrossRef
• The effect of yoga practices on health parameters: A review
  Gökhan Çetinoğlu, Emirhan Pehlivan
  Turkish Journal of Kinesiology.2024; 10(1): 41.     CrossRef
• Managing Diabetic Complications with Alternative Therapeutic Strategies
  Shobhit Prakash Srivastava, Pawan Upadhyay, Shibu Das, Neha Tiwari, Sudhanshu Mishra, Shivendra Mani Tripathi
  Current Diabetes Reviews.2024;[Epub]     CrossRef
• Novel Approaches to Control Diabetes
  Malissa Mathew Dmello, Geeta Bhagwat
  Current Diabetes Reviews.2024;[Epub]     CrossRef
• A Study on Yoga-Based Lifestyle Intervention versus Dietary Intervention Alone on Cardiometabolic Risk Factors among People with Prediabetes
  Neha Saboo, Sudhanshu Kacker
  Annals of African Medicine.2024; 23(2): 202.     CrossRef
• Yoga and its effect on sperm genomic integrity, gene expression, telomere length and perceived quality of life in early pregnancy loss
  Vidhu Dhawan, Neena Malhotra, Neeta Singh, Vatsla Dadhwal, Rima Dada
  Scientific Reports.2024;[Epub]     CrossRef
• Harmony in Health: A Narrative Review Exploring the Interplay of Mind, Body, and Diabetes with a Special Emphasis on Emotional Stress
  Jayakrishnan Balakrishnanpillai, Jothydev Kesavadev, Banshi Saboo
  Journal of Diabetology.2024; 15(2): 123.     CrossRef
• Reversal of type 2 diabetes mellitus through integrated Ayurveda dietary protocol – A case report
  Suketha Kumari, Basavaraj R. Tubaki, Rekha S. Patil, S.D. Laxmikant
  Journal of Ayurveda and Integrative Medicine.2024; 15(4): 100946.     CrossRef
• EFFECTIVENESS OF YOGA THERAPY IN RURAL WOMEN WITH TYPE II DIABETES MELLITUS (T2DM)
  Chirag Andhariya, Kashyapnath Upadhyay, Rupal Gandhi, Minal Panchal
  Divyayatan - A Journal of Lakulish Yoga University.2024; 1(3): 5.     CrossRef
• Efficacy of Standardized Yoga Asanas as Add-on Therapy in the Management of Hypothyroidism: A Randomized, Open-label, Controlled Clinical Study
  Tanu Sharma, Bhavy Goyal, Khan Afreen Mustaq Ahmed, Guru Deo, Ishita Kaushik, Rohit Malik, Vineet Jain, Dharmander Singh, Sunil Kohli, Kailash Chandra
  International Journal of Yoga.2024; 17(2): 124.     CrossRef
• An integrated approach of yoga therapy and naturopathy for the treatment of hypothyroidism – An experimental single case report
  Savithri Nilkantham, Harini K N, Amit Singh
  Advances in Integrative Medicine.2024; 11(4): 247.     CrossRef
• A THREE MONTHS YOGA PROGRAM ON COGNITIVE VARIABLES OF DEMENTIA RISK PARTICIPANTS: A PILOT STUDY
  Manisha Singh, Dr. Divyansh Jain
  Divyayatan - A Journal of Lakulish Yoga University.2024; 1(3): 41.     CrossRef
• Yoga at Primary Health Centers – A Pathway to Holistic Health: Narrative Review
  Priya Gupta
  International Journal of Yoga.2024; 17(2): 93.     CrossRef
• Impact of Yoga Practice on Lipid Profile and Insulin Resistance in Overweight and Obese Individuals – A Pilot Study
  Abhijeet Shelke, Ramesh Kawade, Subhradeep Bhattacharya, Vishal Sarkar, Neevhashiny Selvaraj
  Journal of the Scientific Society.2024;[Epub]     CrossRef
• Role of Yoga in Modulating Vascular Aging in Type 2 Diabetes Mellitus
  Vijaykumar G Warad, Akhil Reddy Kankanala, Anuja M Kadagud, Jyoti P Khodnapur
  Cureus.2024;[Epub]     CrossRef
• Improvement in symptoms of anxiety and depression in individuals with type 2 diabetes: retrospective analysis of an intensive lifestyle modification program
  Pramod Tripathi, Baby Sharma, Nidhi Kadam, Diptika Tiwari, Thejas Kathrikolly, Anagha Vyawahare, Mayurika Das Biswas, Venugopal Vijayakumar, Maheshkumar Kuppusamy, Malhar Ganla, Banshi Saboo
  BMC Psychiatry.2024;[Epub]     CrossRef
• Diabetes Remission After Radical Nephrectomy in a Geriatric Patient With Obesity and Type 2 Diabetes—34 Months’ Follow-Up
  Pramod Tripathi, Nidhi Kadam, Baby Sharma, Manisha Shah, Venugopal Vijayakumar, Maheshkumar Kuppusamy
  JCEM Case Reports.2024;[Epub]     CrossRef
• A self-management plus mind body intervention for adolescents and young adults with type 2 diabetes: Trial design and methodological report
  Molly McVoy, David Miller, Irina Bransteter, Rose Gubitosi-Klug, Tracy Segal, Jessica Surdam, Martha Sajatovic, Jeffery A. Dusek
  Contemporary Clinical Trials.2023; 133: 107317.     CrossRef
• Epidemiology of type 2 diabetes mellitus and treatment utilization patterns among the elderly from the first wave of Longitudinal Aging study in India (2017-18)using a Heckman selection model
  Papai Barman, Milan Das, Madhur Verma
  BMC Public Health.2023;[Epub]     CrossRef
• Is Type 2 Diabetes Mellitus a Behavioural Disorder? An Evidence Review for Type 2 Diabetes Mellitus Prevention and Remission through Lifestyle Modification
  Matthias Li, Mohammad Sadiq Jeeyavudeen, Ganesan Arunagirinathan, Joseph Pappachan
  European Endocrinology.2023; 19(1): 7.     CrossRef
• Yogic practices for dyslipidemia in type 2 diabetes mellitus
  Bandana Sairem, Khushbu Jain
  BLDE University Journal of Health Sciences.2023; 8(1): 20.     CrossRef
• Effect of yoga protocol in primary snoring: A pilot study
  JojanJ Jerone, Ashok Patil, SavitaS Angadi, AmalS Chandran
  Journal of Ayurveda.2023; 17(2): 114.     CrossRef
• Effects of different mind-body exercises on glucose and lipid metabolism in patients with type 2 diabetes: A network meta-analysis
  Sijun Wu, Lin Wang, Yuxuan He, Fengrui Shi, Huiqi Zhuang, Linqi Mei, Youling Qian
  Complementary Therapies in Clinical Practice.2023; 53: 101802.     CrossRef
• Mechanisms of improved body composition among perimenopausal women practicing Meditative Movement: a proposed biobehavioral model
  Dara L. James, Linda K. Larkey, Bronwynne Evans, Ann Sebren, Kimberley Goldsmith, Erica Ahlich, Nanako A. Hawley, Afton Kechter, Dorothy D. Sears
  Menopause.2023; 30(11): 1114.     CrossRef
• A comparative analysis of Vamana and Shamana Chikitsa in prediabetes management: A randomized clinical trial
  Uttamram Yadav, Santosh Kumar Bhatted
  Journal of Ayurveda and Integrative Medicine.2023; 14(5): 100764.     CrossRef
• Siddha Therapeutic Approach to Diabetic Nephropathy – A Review
  P. Parvathy, G. S. Lekha, S. Aparna, A. Kanagarajan
  Journal of Natural Remedies.2023; : 1359.     CrossRef
• Enhancing Type 2 Diabetes Management: Exploring the Synergistic Impact of Vestibular Exercise and Yoga
  Athira MS, Sheela Joice P P, Mohan Varughese, Suresh Babu Sayana
  Cureus.2023;[Epub]     CrossRef
• Dynamic In Silico Model of Type 2 Diabetes Treated With Metformin Combined With Exercise: A Sobol Sensitivity Analysis
  Darshna M. Joshi
  Avicenna Journal of Pharmaceutical Research.2023; 3(2): 91.     CrossRef
• Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
  Shradha S Parsekar, Nachiket Gudi, Sujata Chodankar Walke, Prabhu Dutta Shaw, Aditi Hombali, Anupama V Nayak, Basavaraj S Hadapad
  F1000Research.2023; 11: 526.     CrossRef
• Exploring the Impact of Combined Thai Yoga and Elastic Band Exercise on Physical Fitness and Exercise Capacity in Older Patients with Type 2 Diabetes
  Nattha Muangritdech, Tichanon Promsrisuk, Ratchaniporn Kongsui, Napatr Sriraksa, Sitthisak Thongrong, Arunrat Srithawong
  Physical Education Theory and Methodology.2023; 23(6): 894.     CrossRef
• A Study to Assess and Correlate Metabolic Parameters with Carotid Intima-Media Thickness after Combined Approach of Yoga Therapy Among Prediabetics
  Neha Saboo, Sudhanshu Kacker
  Advanced Biomedical Research.2023;[Epub]     CrossRef
• Beyond the Mat: Exploring the Potential Clinical Benefits of Yoga on Epigenetics and Gene Expression: A Narrative Review of the Current Scientific Evidence
  Selvaraj Giridharan
  International Journal of Yoga.2023; 16(2): 64.     CrossRef
• Influence of 24-Week Yoga Intervention on Cardiovascular Risk Factors and Inflammatory Markers in Type 2 Diabetes
  Sonali Sharma, Sonal Bhardwaj, Arvind Gupta, Vishwa Mohan Katoch, Krishna Kumar Sharma, Rajeev Gupta
  International Journal of Yoga.2023; 16(1): 27.     CrossRef
• Role of Yoga and Its Plausible Mechanism in the Mitigation of DNA Damage in Type-2 Diabetes: A Randomized Clinical Trial
  Rajesh G Nair, Mithila M Vasudev, Ramesh Mavathur
  Annals of Behavioral Medicine.2022; 56(3): 235.     CrossRef
• Efficacy of Integrated Ayurveda treatment protocol in type 2 Diabetes Mellitus – A case report
  Suketha Kumari, Laxmikant S.D, Sonika B, Suman Khanal
  Journal of Ayurveda and Integrative Medicine.2022; 13(1): 100512.     CrossRef
• Role of structured exercise therapy on cognitive markers and stress parameters in young patients with Type 2 diabetes mellitus
  Harpreet Kour, VA Kothiwale, ShivaprasadS Goudar
  Indian Journal of Health Sciences and Biomedical Research (KLEU).2022; 15(1): 70.     CrossRef
• The Influence of Amateur Sports on Health Quality
  M. M. Vovchenko
  Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2022; 7(1): 8.     CrossRef
• Complementary and alternative system of medicine for type 2 diabetes mellitus and its complications: A scoping review
  Shradha S Parsekar, Nachiket Gudi, Sujata Chodankar Walke, Prabhu Dutta Shaw, Aditi Hombali, Anupama V Nayak, Basavaraj S Hadapad
  F1000Research.2022; 11: 526.     CrossRef
• Neuroimaging perspective in targeted treatment for type 2 diabetes melitus and sleep disorders
  Karen M. von Deneen, Malgorzata A. Garstka
  Intelligent Medicine.2022; 2(4): 209.     CrossRef
• Efficacy of yoga practices on emotion regulation and mindfulness in type 2 diabetes mellitus patients
  Amit Kanthi, Singh Deepeshwar, Chidananda Kaligal, Mahadevappa Vidyashree, Dwivedi Krishna
  Yoga Mimamsa.2022; 54(1): 12.     CrossRef
• Inside the diabetic brain: Insulin resistance and molecular mechanism associated with cognitive impairment and its possible therapeutic strategies
  Bhaskar Jyoti Dutta, Shamsher Singh, Sanket Seksaria, Ghanshyam Das Gupta, Amrita Singh
  Pharmacological Research.2022; 182: 106358.     CrossRef
• LINKAGE OF YOGA TO OXIDATIVE STRESS IN PATIENTS WITH DIABETES MELLITUS, TYPE 2
  Deepika Khatri, Yuliya Tyravska
  InterConf.2022; (15(117)): 215.     CrossRef
• An Observational Study on the Effect of Yoga and Sudarshan Kriya in Type 2 Diabetes Mellitus Patients
  Meenakshi R Verma, Deepakkumar G Langade, Rahul D Rao, Shreya Shivangi, Sonali Khedkar, Divya Kanchibhotla
  Cureus.2022;[Epub]     CrossRef
• The most effective exercise to prevent obesity: A longitudinal study of 33,731 Taiwan biobank participants
  Wan-Yu Lin
  Frontiers in Nutrition.2022;[Epub]     CrossRef
• Type 2 diabetes mellitus, its impact on quality of life and how the disease can be managed-a review
  Priyanka Garg, Navneet Duggal
  Obesity Medicine.2022; 35: 100459.     CrossRef
• Effect of om chanting and yoga nidra on blood pressure and lipid profile in hypertension – A randomized controlled trial
  K. Anjana, R. Archana, J.K. Mukkadan
  Journal of Ayurveda and Integrative Medicine.2022; 13(4): 100657.     CrossRef
• Effect of yoga intervention on skeletal muscle linked glucose homeostasis in pre-diabetic individuals: Study protocol for a randomized controlled trial
  Supriya Bhalerao, Jayshree Kharche, Shubhangi Harke
  Advances in Integrative Medicine.2022; 9(4): 230.     CrossRef
• Popular Complementary and Alternative Therapy Methods in Different Conditions
  Akın SÜZER, Nevriye ÜNAL SÜZER, Raziye ŞAVKIN, Nihal BÜKER
  International Journal of Traditional and Complementary Medicine Research.2022; 3(3): 201.     CrossRef
• Add on Hypoglycemic effect of customized Yoga module in diabetes mellitus
  K. K. Resmi, M. B. Kavita, Gurubasavaraj Yalagachin
  Journal of Ayurveda Case Reports.2022; 5(4): 163.     CrossRef
• Modern Postural Yoga and the Health-Spirituality-Neoliberalism Nexus
  Matteo Di Placido, Anna Strhan, Stefania Palmisano
  Fieldwork in Religion.2022;[Epub]     CrossRef
• Metabolic syndrome and possible treatments (consecutive therapies): a literature review
  Jitender Sorout, Sudhanshu Kacker, Neha Saboo
  INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2022; 18(6): 351.     CrossRef
• Effect of non-pharmacological interventions on adults with cardiovascular risk in a rural community
  Santosh Kumar, Ravi Kant, Poonam Yadav, Barun Kumar
  Journal of Family Medicine and Primary Care.2022; 11(9): 5521.     CrossRef
• Impact of an Integrated Yoga Therapy Protocol on Insulin Resistance and Glycemic Control in Patients with Type 2 Diabetes Mellitus
  Manoharan Mangala Gowri, Jayanthi Rajendran, Abu Srinivasan, Ananda Balayogi Bhavanani, Ramanathan Meena
  Rambam Maimonides Medical Journal.2022; 13(1): e0005.     CrossRef
• Umbilical Cord-Mesenchymal Stem Cell-Conditioned Medium Improves Insulin Resistance in C2C12 Cell
  Kyung-Soo Kim, Yeon Kyung Choi, Mi Jin Kim, Jung Wook Hwang, Kyunghoon Min, Sang Youn Jung, Soo-Kyung Kim, Yong-Soo Choi, Yong-Wook Cho
  Diabetes & Metabolism Journal.2021; 45(2): 260.     CrossRef
• Yoga as a complementary therapy for metabolic syndrome: A narrative review
  Dastan M. Khoshnaw, Abhijit A. Ghadge
  Journal of Integrative Medicine.2021; 19(1): 6.     CrossRef
• Effect of yoga on glycemia and lipid parameters in type-2 diabetes: a meta-analysis
  Deep Dutta, Saptarshi Bhattacharya, Meha Sharma, Deepak Khandelwal, Vineet Surana, Sanjay Kalra
  Journal of Diabetes & Metabolic Disorders.2021; 20(1): 349.     CrossRef
• Effect of Yoga on Glucose Control and Quality of Life in Patients of Prediabetes
  Rajesh Rajput, Karamvir Yadav, Meena Rajput, Jyoti Yadav, Neharika Saini
  Metabolic Syndrome and Related Disorders.2021; 19(8): 417.     CrossRef
• Effect of long-term Yogic practices in type 2 diabetes mellitus
  Ketaki H. Patil, Vidya Wasnik (Thatere), Vijay G. Patrikar
  Journal of Indian System of Medicine.2021; 9(2): 135.     CrossRef
• Effectiveness of Yoga Lifestyle on Lipid Metabolism in a Vulnerable Population—A Community Based Multicenter Randomized Controlled Trial
  Raghuram Nagarathna, Saurabh Kumar, Akshay Anand, Ishwara N. Acharya, Amit Kumar Singh, Suchitra S. Patil, Ramesh H Latha, Purnima Datey, Hongasandra Ramarao Nagendra
  Medicines.2021; 8(7): 37.     CrossRef
• Yoga for Healthy Aging: Science or Hype?
  
  Advances in Geriatric Medicine and Research.2021;[Epub]     CrossRef
• A Prospective Study on Type-2 Diabetic Complications and Efficacy of Integrated Yoga: A Pan India 2017
  Suchitra S. Patil, Nagarathna Raghuram, Amit Singh, S. K. Rajesh, Sabzar Ahmed, Nagendra Hongasandra
  Annals of Neurosciences.2021; 28(1-2): 21.     CrossRef
• Effects of Yoga Therapy and Walking Therapy in Reducing Blood Sugar Levels on Diabetes Mellitus Patients in the Community
  Wachidah Yuniartika, Agus Sudaryanto, Abi Muhlisin, Dian Hudiyawati, Dimas Ria Angga Pribadi
  Open Access Macedonian Journal of Medical Sciences.2021; 9(E): 906.     CrossRef
• Yoga nidra practice shows improvement in sleep in patients with chronic insomnia: A randomized controlled trial
  KARUNA DATTA, MANJARI TRIPATHI, MANSI VERMA, DEEPIKA MASIWAL, HRUDA NANDA MALLICK
  The National Medical Journal of India.2021; 34: 143.     CrossRef
• MANAGEMENT THROUGH AYURVEDIC MEDICATIONS AND LIFESTYLE MODIFICATION (PATHYASEVANA AND YOGASANA) IN A CASE OF POST-COVID COMPLICATION DIABETES MELLITUS (TYPE 2 DM): A SINGLE CASE STUDY
  Prajakta D. Nimje, Vidya Wasnik (Thatere), Sumeeta Jain
  International Ayurvedic Medical Journal.2021; 9(10): 2619.     CrossRef
• Efficacy of palliative herbal decoction (Darvyadi Kwatha) with lifestyle modification in the management of prediabetes (Prameha)
  Uttamram Yadav, Santosh K. Bhatted
  Journal of Indian System of Medicine.2021; 9(4): 265.     CrossRef
• Role of yoga as an adjuvant therapy in the management of metabolic syndrome – A randomized control pilot study
  Rajasekaran Balaji, Meena Ramanathan, Ananda Balayogi Bhavanani
  Yoga Mimamsa.2021; 53(2): 116.     CrossRef
• Impact of Yoga Intervention on Physical and Mental Health of Adults with Type 2 Diabetes
  Subramani Poongothai, Ashok Vidyulatha, Thameem Nisha, Mokkapati Lalasa, Balasundaram Bhavani Sundari, Kulasegaran Karkuzhali, Muniyandi Thanujah, Satish Latha
  Journal of Diabetology.2021; 12(4): 517.     CrossRef
• Study on Yoga Practices and Biochemical, Physical and Physiological Alterations
  Pradeep Kumar, Rohit Agrawal, Rohit Bhagat, MK Yadav, Alka Agrawaal, Preeti Sharma
  Journal of Datta Meghe Institute of Medical Sciences University.2021; 16(3): 470.     CrossRef
• Effect of an 8-Week Yoga-Based Lifestyle Intervention on Psycho-Neuro-Immune Axis, Disease Activity, and Perceived Quality of Life in Rheumatoid Arthritis Patients: A Randomized Controlled Trial
  Surabhi Gautam, Manoj Kumar, Uma Kumar, Rima Dada
  Frontiers in Psychology.2020;[Epub]     CrossRef
• Type 2 diabetes mellitus: pathogenesis and genetic diagnosis
  D. Himanshu, Wahid Ali, Mohd Wamique
  Journal of Diabetes & Metabolic Disorders.2020; 19(2): 1959.     CrossRef
• Prevalence and Awareness of Stroke and Other Comorbidities Associated with Diabetes in Northwest India
  Vivek Podder, Vinod Srivastava, Saurabh Kumar, Raghuram Nagarathna, Madhava Sai Sivapuram, Navneet Kaur, Kanupriya Sharma, Amit Kumar Singh, Neeru Malik, Akshay Anand, Hongasandra R. Nagendra
  Journal of Neurosciences in Rural Practice.2020; 11: 467.     CrossRef
• Patterns of concomitant use of Ayurveda and conventional anti-diabetic formulations - Experiences at a tertiary care Ayurveda hospital, India
  R Galib, Poonam Dang, Vijay Kumar, Rakesh Rana, Pramod Yadav, PK Prajapati
  AYU (An international quarterly journal of research in Ayurveda).2020; 41(2): 72.     CrossRef
• A perspective on yoga as a preventive strategy for coronavirus disease 2019
  R Nagarathna, HR Nagendra, Vijaya Majumdar
  International Journal of Yoga.2020; 13(2): 89.     CrossRef
• Effect of Ayurveda intervention, lifestyle modification and Yoga in prediabetic and type 2 diabetes under the National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS)–AYUSH integration project
  Ramavtar Sharma, VinodKumar Shahi, Shruti Khanduri, Arun Goyal, Suhas Chaudhary, RakeshKumar Rana, Richa Singhal, Narayanam Srikanth, KartarSingh Dhiman
  AYU (An international quarterly journal of research in Ayurveda).2019; 40(1): 8.     CrossRef
• Type 2 diabetes mellitus, physical activity, yoga and telomere length: A literature review
  Reepa A. Ughreja, Reena A. Ughreja
  Journal of Metabolic Health.2019;[Epub]     CrossRef

Wnt/β-catenin signaling plays a critical role in the achievement of peak bone mass, affecting the commitment of mesenchymal progenitors to the osteoblast lineage and the anabolic capacity of osteoblasts depositing bone matrix. Recent studies suggest that this evolutionarily-conserved, developmental pathway exerts its anabolic effects in part by coordinating osteoblast activity with intermediary metabolism. These findings are compatible with the cloning of the gene encoding the low-density lipoprotein related receptor-5 (LRP5) Wnt co-receptor from a diabetes-susceptibility locus and the now well-established linkage between Wnt signaling and metabolism. In this article, we provide an overview of the role of Wnt signaling in whole-body metabolism and review the literature regarding the impact of Wnt signaling on the osteoblast's utilization of three different energy sources: fatty acids, glucose, and glutamine. Special attention is devoted to the net effect of nutrient utilization and the mode of regulation by Wnt signaling. Mechanistic studies indicate that the utilization of each substrate is governed by a unique mechanism of control with β-catenin-dependent signaling regulating fatty acid β-oxidation, while glucose and glutamine utilization are β-catenin-independent and downstream of mammalian target of rapamycin complex 2 (mTORC2) and mammalian target of rapamycin complex 1 (mTORC1) activation, respectively. The emergence of these data has provided a new context for the mechanisms by which Wnt signaling influences bone development.

Citations

Citations to this article as recorded by  

• Aseptic loosening around total joint replacement in humans is regulated by miR-1246 and miR-6089 via the Wnt signalling pathway
  Yi Deng, Kate Phillips, Zhi-Ping Feng, Paul N. Smith, Rachel W. Li
  Journal of Orthopaedic Surgery and Research.2024;[Epub]     CrossRef
• Cardamonin inhibits osteogenic differentiation by downregulating Wnt/beta‐catenin signaling and alleviates subchondral osteosclerosis in osteoarthritic mice
  Fanding Meng, Pengchong Zhu, Xiaoli Ren, Limei Wang, Dong Ding, Jiangbo Yan, Ying Zhang, Shang‐You Yang, Bin Ning
  Journal of Orthopaedic Research.2024; 42(9): 1933.     CrossRef
• miRNAs dysregulation in ankylosing spondylitis: A review of implications for disease mechanisms, and diagnostic markers
  Osama A. Mohammed, Mushabab Alghamdi, Masoud I.E. Adam, Waad Fuad BinAfif, Jaber Alfaifi, Mohannad Mohammad S. Alamri, Abdullah Ali Alqarni, Abdullah Hassan Alhalafi, Emad Bahashwan, AbdulElah Al Jarallah AlQahtani, Abdullah Ayed, Rania H. Hassan, Mustafa
  International Journal of Biological Macromolecules.2024; 268: 131814.     CrossRef
• A proteomics approach to study mouse long bones: examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice
  Christopher J. Chermside-Scabbo, John T. Shuster, Petra Erdmann-Gilmore, Eric Tycksen, Qiang Zhang, R. Reid Townsend, Matthew J. Silva
  Aging.2024; 16(19): 12726.     CrossRef
• Towards an enhanced understanding of osteoanabolic effects of PTH-induced microRNAs on osteoblasts using a bioinformatic approach
  Lucija Ana Vrščaj, Janja Marc, Barbara Ostanek
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• Regulation of bone homeostasis: signaling pathways and therapeutic targets
  Zebin Wu, Wenming Li, Kunlong Jiang, Zhixiang Lin, Chen Qian, Mingzhou Wu, Yu Xia, Ning Li, Hongtao Zhang, Haixiang Xiao, Jiaxiang Bai, Dechun Geng
  MedComm.2024;[Epub]     CrossRef
• Wnt3a-induced LRP6 phosphorylation enhances osteoblast differentiation to alleviate osteoporosis through activation of mTORC1/β-catenin signaling
  Xiang Shen, Shuolin Feng, Shanbin Chen, Bin Gong, Suiyuan Wang, Huan Wang, Deye Song, Jiangdong Ni
  Archives of Biochemistry and Biophysics.2024; 761: 110169.     CrossRef
• Protective effects of electroacupuncture on senile osteoporosis in rats
  Jun Zhou, Jinling Wang, Mengjian Qu, Qian Wang, Liqiong Wang, Sijia Liu, Jing Liu, Guanghua Sun, Peirui Zhong, Xiarong Huang, Danni Liu, Linwei Yin, Chengqi He
  Acupuncture in Medicine.2024;[Epub]     CrossRef
• Common Regulators of Lipid Metabolism and Bone Marrow Adiposity in Postmenopausal Women
  Dae-Yong Kim, Seong-Hee Ko
  Pharmaceuticals.2023; 16(2): 322.     CrossRef
• Novel mutation in LRP5 gene cause rare osteosclerosis: cases studies and literature review
  Dichen Zhao, Lei Sun, Wenbin Zheng, Jing Hu, Bingna Zhou, Ou Wang, Yan Jiang, Weibo Xia, Xiaoping Xing, Mei Li
  Molecular Genetics and Genomics.2023; 298(3): 683.     CrossRef
• RUNX Family as a Promising Biomarker and a Therapeutic Target in Bone Cancers: A Review on Its Molecular Mechanism(s) behind Tumorigenesis
  Selvaraj Vimalraj, Saravanan Sekaran
  Cancers.2023; 15(12): 3247.     CrossRef
• FGF19 protects against obesity-induced bone loss by promoting osteogenic differentiation
  Ai Guo, Kai Li, Hong-Chuan Tian, Bai-Long Tao, Qian Xiao, Dian-Ming Jiang
  Biomedicine & Pharmacotherapy.2022; 146: 112524.     CrossRef
• Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts
  Sarocha Suthon, Jianjian Lin, Rachel S. Perkins, John R. Crockarell, Gustavo A. Miranda-Carboni, Susan A. Krum
  The American Journal of Human Genetics.2022; 109(1): 97.     CrossRef
• Exposure of primary osteoblasts to combined magnetic and electric fields induced spatiotemporal endochondral ossification characteristic gene- and protein expression profiles
  Klaus H. Dittmann, Claus Mayer, Heribert Stephan, Christin Mieth, Michael Bonin, Beat Lechmann, H. Peter Rodemann
  Journal of Experimental Orthopaedics.2022;[Epub]     CrossRef
• Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1α and activating the Wnt/β-catenin signaling pathway
  Luyao Li, Afang Li, Li Zhu, Liangying Gan, Li Zuo
  Journal of Orthopaedic Surgery and Research.2022;[Epub]     CrossRef
• T-cell factor 7L2 is a novel regulator of osteoblast functions that acts in part by modulation of hypoxia signaling
  Subburaman Mohan, Chandrasekhar Kesavan
  American Journal of Physiology-Endocrinology and Metabolism.2022; 322(6): E528.     CrossRef
• Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications
  Ioannis Akoumianakis, Murray Polkinghorne, Charalambos Antoniades
  Nature Reviews Cardiology.2022; 19(12): 783.     CrossRef
• Osteoporosis pathogenesis and treatment: existing and emerging avenues
  Bo Liang, George Burley, Shu Lin, Yan-Chuan Shi
  Cellular & Molecular Biology Letters.2022;[Epub]     CrossRef
• QingreHuoxue decoction protects joint and toe bone morphology and structure in rats with active RA through bidirectional regulation of bone metabolism
  Hui Yang, Zhenyu Wu, Xun Gong, Bo Li, Guangjun Wu, Quan Jiang
  Pharmacological Research - Modern Chinese Medicine.2022; 4: 100156.     CrossRef
• Regulation of Wnt signaling by non-coding RNAs during osteoblast differentiation
  I. Saranya, R.L. Akshaya, N. Selvamurugan
  Differentiation.2022; 128: 57.     CrossRef
• Looking at Mountains: Role of Sustained Hypoxia in Regulating Bone Mineral Homeostasis in Relation to Wnt Pathway and Estrogen
  Lijy K. Babu, Dishari Ghosh
  Clinical Reviews in Bone and Mineral Metabolism.2022; 20(1-4): 18.     CrossRef
• Effect of the Pulsed Electromagnetic Field Treatment in a Rat Model of Senile Osteoporosis In Vivo
  Jun Zhou, Jinling Wang, Mengjian Qu, Xiarong Huang, Linwei Yin, Yang Liao, Fujin Huang, Pengyun Ning, Peirui Zhong, Yahua Zeng
  Bioelectromagnetics.2022; 43(7): 438.     CrossRef
• Arm race between Rift Valley fever virus and host
  Xiao Wang, Yupei Yuan, Yihan Liu, Leiliang Zhang
  Frontiers in Immunology.2022;[Epub]     CrossRef
• Differential bone metabolism and protein expression in mice fed a high-fat diet versus Daurian ground squirrels following natural pre-hibernation fattening
  Xuli Gao, Shenyang Shen, Qiaohua Niu, Weilan Miao, Yuting Han, Ziwei Hao, Ning An, Yingyu Yang, Yu Zhang, Han Zhang, Kenneth B. Storey, Hui Chang
  Journal of Zhejiang University-SCIENCE B.2022; 23(12): 1042.     CrossRef
• miR‐142a‐5p promoted osteoblast differentiation via targeting nuclear factor IA
  Hairui Yuan, Mengyue Li, Xue Feng, Endong Zhu, Baoli Wang
  Journal of Cellular Physiology.2021; 236(3): 1810.     CrossRef
• Serum sclerostin and glucose homeostasis: No association in healthy men. Cross-sectional and prospective data from the EGIR-RISC study
  Jens-Jacob L. Lauterlein, Pernille Hermann, Thomas Konrad, Peter Wolf, Peter Nilsson, Rafael Gabriel Sánchez, Ele Ferrannini, Beverley Balkau, Kurt Højlund, Morten Frost
  Bone.2021; 143: 115681.     CrossRef
• Energy Metabolism and Ketogenic Diets: What about the Skeletal Health? A Narrative Review and a Prospective Vision for Planning Clinical Trials on this Issue
  Daniela Merlotti, Roberta Cosso, Cristina Eller-Vainicher, Fabio Vescini, Iacopo Chiodini, Luigi Gennari, Alberto Falchetti
  International Journal of Molecular Sciences.2021; 22(1): 435.     CrossRef
• Therapeutic potential of iron chelators on osteoporosis and their cellular mechanisms
  Jian Zhang, Hai Zhao, Gang Yao, Penghai Qiao, Longfei Li, Shuguang Wu
  Biomedicine & Pharmacotherapy.2021; 137: 111380.     CrossRef
• Insertion of gallic acid onto chitosan promotes the differentiation of osteoblasts from murine bone marrow-derived mesenchymal stem cells
  Yunok Oh, Chang-Bum Ahn, M.P.C.K. Marasinghe, Jae-Young Je
  International Journal of Biological Macromolecules.2021; 183: 1410.     CrossRef
• Biological Mechanisms of Paeonoside in the Differentiation of Pre-Osteoblasts and the Formation of Mineralized Nodules
  Kyung-Ran Park, Joon Yeop Lee, Myounglae Cho, Jin Tae Hong, Hyung-Mun Yun
  International Journal of Molecular Sciences.2021; 22(13): 6899.     CrossRef
• Enamel matrix derivative (EMD) enhances the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs)
  Lu Cheng, Ying Li, Qian Xia, MaoHua Meng, ZhaoYang Ye, ZhengLong Tang, HongChao Feng, Xin Chen, HeLin Chen, Xiao Zeng, Yi Luo, Qiang Dong
  Bioengineered.2021; 12(1): 7033.     CrossRef
• Synthesized Nanorods Hydroxyapatite by Microwave-Assisted Technology for In Vitro Osteoporotic Bone Regeneration through Wnt/β-Catenin Pathway
  Nadia Z. Shaban, Marwa Y. Kenawy, Nahla A. Taha, Mona M. Abd El-Latif, Doaa A. Ghareeb
  Materials.2021; 14(19): 5823.     CrossRef
• Chlorogenic Acids Inhibit Adipogenesis: Implications of Wnt/β-Catenin Signaling Pathway
  Mengting Liu, Jian Qin, Jing Cong, Yubin Yang, Muhittin Yurekli
  International Journal of Endocrinology.2021; 2021: 1.     CrossRef
• Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation
  Jelena Krstić, Slavko Mojsilović, Sonja S Mojsilović, Juan F Santibanez
  World Journal of Stem Cells.2021; 13(11): 1699.     CrossRef
• Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation
  Jelena Krstić, Slavko Mojsilović, Sonja S Mojsilović, Juan F Santibanez
  World Journal of Stem Cells.2021; 13(11): 1696.     CrossRef
• The Skeletal Cellular and Molecular Underpinning of the Murine Hindlimb Unloading Model
  Priyanka Garg, Maura Strigini, Laura Peurière, Laurence Vico, Donata Iandolo
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Changes in Serum Dickkopf-1, RANK Ligand, Osteoprotegerin, and Bone Mineral Density after Allogeneic Hematopoietic Stem Cell Transplantation Treatment
  Eunhee Jang, Jeonghoon Ha, Ki-Hyun Baek, Moo Il Kang
  Endocrinology and Metabolism.2021; 36(6): 1211.     CrossRef
• Amyloid β peptide promotes bone formation by regulating Wnt/β‐catenin signaling and the OPG/RANKL/RANK system
  Bu Yang, Shangfu Li, Zheng Chen, Feng Feng, Lei He, Bin Liu, Tianwei He, Xuan Wang, Ruiqiang Chen, Zihao Chen, Peigen Xie, Limin Rong
  The FASEB Journal.2020; 34(3): 3583.     CrossRef
• Evaluation of chondrogenesis and osteogenesis via Wnt/β-Catenin, S100 immunoexpression and histomorphometry in fetal rats following maternal uterine artery ligation
  Serap USLU, Gülperi ÖKTEM, Fatih OLTULU, Kenan DEMİR, Arzu İRBAN, Gülçin BAŞDEMİR, Ümit İNCE, Ayşegül UYSAL
  Ege Tıp Dergisi.2020; 59(1): 39.     CrossRef
• Dual Effects of Lipid Metabolism on Osteoblast Function
  Nathalie S. Alekos, Megan C. Moorer, Ryan C. Riddle
  Frontiers in Endocrinology.2020;[Epub]     CrossRef
• Mesenchymal stem cells: amazing remedies for bone and cartilage defects
  Parisa Kangari, Tahereh Talaei-Khozani, Iman Razeghian-Jahromi, Mahboobeh Razmkhah
  Stem Cell Research & Therapy.2020;[Epub]     CrossRef
• Blue Mussel-Derived Peptides PIISVYWK and FSVVPSPK Trigger Wnt/β-Catenin Signaling-Mediated Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells
  Yunok Oh, Chang-Bum Ahn, Jae-Young Je
  Marine Drugs.2020; 18(10): 510.     CrossRef
• Interleukin-35 stimulates tumor necrosis factor-α activated osteoblasts differentiation through Wnt/β-catenin signaling pathway in rheumatoid arthritis
  Yuxuan Li, Lin Yuan, Shenyi Jiang, Siyan Liu, Liping Xia, Hui Shen, Jing Lu
  International Immunopharmacology.2019; 75: 105810.     CrossRef
• The roles of Orai and Stim in bone health and disease
  Lisa J. Robinson, Harry C. Blair, John B. Barnett, Jonathan Soboloff
  Cell Calcium.2019; 81: 51.     CrossRef

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease that is characterized by the formation of heterotopic bone tissues in soft tissues, such as skeletal muscle, ligament, and tendon. It is difficult to remove such heterotopic bones via internal medicine or invasive procedures. The identification of activin A receptor, type I (ACVR1)/ALK2 gene mutations associated with FOP has allowed the genetic diagnosis of FOP. The ACVR1/ALK2 gene encodes the ALK2 protein, which is a transmembrane kinase receptor in the transforming growth factor-β family. The relevant mutations activate intracellular signaling in vitro and induce heterotopic bone formation in vivo. Activin A is a potential ligand that activates mutant ALK2 but not wild-type ALK2. Various types of small chemical and biological inhibitors of ALK2 signaling have been developed to establish treatments for FOP. Some of these are in clinical trials in patients with FOP.

Citations

Citations to this article as recorded by  

• How Activin A Became a Therapeutic Target in Fibrodysplasia Ossificans Progressiva
  Dushyanth Srinivasan, Martin Arostegui, Erich J. Goebel, Kaitlin N. Hart, Senem Aykul, John B. Lees-Shepard, Vincent Idone, Sarah J. Hatsell, Aris N. Economides
  Biomolecules.2024; 14(1): 101.     CrossRef
• BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension
  Hui Shen, Ya Gao, Dedong Ge, Meng Tan, Qing Yin, Tong-You Wade Wei, Fangzhou He, Tzong-Yi Lee, Zhongyan Li, Yuqin Chen, Qifeng Yang, Zhangyu Liu, Xinxin Li, Zixuan Chen, Yi Yang, Zhengang Zhang, Patricia A. Thistlethwaite, Jian Wang, Atul Malhotra, Jason
  Circulation.2024; 150(2): 132.     CrossRef
• Current and emerging treatment modalities for fibrodysplasia ossificans progressiva
  Dilan Gençel, Nejla Nur Erbil, Şeniz Demiryürek, Abdullah Tuncay Demiryürek
  Expert Opinion on Pharmacotherapy.2024; 25(16): 2225.     CrossRef
• Fibrodysplasia Ossificans Progressiva Mimics Generalized Dystonia Disorder: A Case Report
  Seraj Makkawi, Osama Khojah, Reema Abualnaja, Abdulaziz Qashqari, Nawaf A Alahmadi, Abdullatif G Bshnaq, Abdulrahman Alharthi, Hashem H Al-Hashemi, Aiman M Shawli
  Cureus.2023;[Epub]     CrossRef
• Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites
  Hiroyuki Yamazaki
  Journal of Natural Medicines.2022; 76(1): 1.     CrossRef
• A Novel De Novo Frameshift Pathogenic Variant in the FAM111B Resulting in Progressive Osseous Heteroplasia Phenotype
  Anna Ryabets-Lienhard, Panadeekarn Panjawatanan, Kyle Vogt, Jianling Ji, Senta Georgia, Pisit Pitukcheewanont
  Calcified Tissue International.2022; 112(4): 518.     CrossRef
• Inhibitory effects of sesquiterpene lactones from the Indonesian marine sponge Lamellodysidea cf. herbacea on bone morphogenetic protein-induced osteoblastic differentiation
  Satoshi Ohte, Hiroyuki Yamazaki, Ohgi Takahashi, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Huiping Zhang, Fumiaki Hayashi, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchid
  Bioorganic & Medicinal Chemistry Letters.2021; 35: 127783.     CrossRef
• Genomic Context and Mechanisms of the ACVR1 Mutation in Fibrodysplasia Ossificans Progressiva
  Roberto Ravazzolo, Renata Bocciardi
  Biomedicines.2021; 9(2): 154.     CrossRef
• New insights on fibrodysplasia ossificans progressiva: discussion of an autoptic case report and brief literature review
  Vittorio Bolcato, Claudia Carelli, Silvia Damiana Visonà, Marcella Reguzzoni, Maja Di Rocco, Alessandra Radogna, Livio Pietro Tronconi, Matteo Moretti
  Intractable & Rare Diseases Research.2021; 10(2): 136.     CrossRef
• Accumulated Knowledge of Activin Receptor-Like Kinase 2 (ALK2)/Activin A Receptor, Type 1 (ACVR1) as a Target for Human Disorders
  Takenobu Katagiri, Sho Tsukamoto, Mai Kuratani
  Biomedicines.2021; 9(7): 736.     CrossRef
• Cytoskeleton Reorganization in EndMT—The Role in Cancer and Fibrotic Diseases
  Wojciech Michał Ciszewski, Marta Ewelina Wawro, Izabela Sacewicz-Hofman, Katarzyna Sobierajska
  International Journal of Molecular Sciences.2021; 22(21): 11607.     CrossRef
• Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate
  Juliana Souza Vieira, Emanuelle Juliana Cunha, Juliana Feltrin de Souza, Luis Henrique Koeler Chaves, Jessica Lakes de Souza, Allan Fernando Giovanini
  World Journal of Experimental Medicine.2020; 10(1): 1.     CrossRef
• ALK2: A Therapeutic Target for Fibrodysplasia Ossificans Progressiva and Diffuse Intrinsic Pontine Glioma
  Katsuhiko Sekimata, Tomohiro Sato, Naoki Sakai
  Chemical and Pharmaceutical Bulletin.2020; 68(3): 194.     CrossRef
• Role of Signal Transduction Pathways and Transcription Factors in Cartilage and Joint Diseases
  Riko Nishimura, Kenji Hata, Yoshifumi Takahata, Tomohiko Murakami, Eriko Nakamura, Maki Ohkawa, Lerdluck Ruengsinpinya
  International Journal of Molecular Sciences.2020; 21(4): 1340.     CrossRef
• Design of primers for direct sequencing of nine coding exons in the human ACVR1 gene
  Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
  Bone.2020; 138: 115469.     CrossRef
• A new diketopiperazine-like inhibitor of bone morphogenetic protein-induced osteoblastic differentiation produced by marine-derived Aspergillus sp. BFM-0085
  Satoshi Ohte, Takehiro Shiokawa, Nobuhiro Koyama, Takenobu Katagiri, Chiaki Imada, Hiroshi Tomoda
  The Journal of Antibiotics.2020; 73(8): 554.     CrossRef
• Penicillic Acid Congener, a New Inhibitor of BMP-Induced Alkaline Phosphatase Activity in Myoblasts, Produced by the Fungus Penicillium sp. BF-0343
  Nobuhiro Koyama, Yasuhiro Otoguro, Satoshi Ohte, Takenobu Katagiri, Hiroshi Tomoda
  Natural Product Communications.2020;[Epub]     CrossRef
• Fibrodysplasia ossificans progressiva: current concepts from bench to bedside
  Arun-Kumar Kaliya-Perumal, Tom J. Carney, Philip W. Ingham
  Disease Models & Mechanisms.2020;[Epub]     CrossRef
• Clinical Aspects and Current Therapeutic Approaches for FOP
  Hiroshi Kitoh
  Biomedicines.2020; 8(9): 325.     CrossRef
• Screening for Small Molecule Inhibitors of BMP-Induced Osteoblastic Differentiation from Indonesian Marine Invertebrates
  Hiroyuki Yamazaki, Satoshi Ohte, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Delfly B. Abdjul, Wilmar Maarisit, Magie M. Kapojos, Michio Namikoshi, Takenobu Katagiri, Hiroshi Tomoda, Ryuji Uchida
  Marine Drugs.2020; 18(12): 606.     CrossRef
• Propranolol and ascorbic acid in control of fibrodysplasia ossificans progressiva flare-ups due to accidental falls
  Durval Batista Palhares, Deborah Ribeiro Nascimento, Marilene Garcia Palhares, Suzana Lopes Bomfim Balaniuc, Liane de Rosso Giuliani, Paula Cristhina Niz Xavier, José Mauro Goulart Brum, Fabiana Alves, Francisco Oliveira Vieira, Elaine Maria Souza-Fagunde
  Intractable & Rare Diseases Research.2019; 8(1): 24.     CrossRef
• Late-onset fibrodysplasia ossificans progressiva with atypical presentation: A case report
  Conor M. Cunningham, J. Matthew Royeca, Samuel W. King, Hemant Pandit
  Case Reports in Women's Health.2019; 23: e00134.     CrossRef
• Fibrodysplasia ossificans progressiva: lessons learned from a rare disease
  Gulseren Akyuz, Kardelen Gencer-Atalay, Pinar Ata
  Current Opinion in Pediatrics.2019; 31(6): 716.     CrossRef
• Discovery of Heterotopic Bone-Inducing Activity in Hard Tissues and the TGF-β Superfamily
  Takenobu Katagiri, Sho Tsukamoto, Yutaka Nakachi, Mai Kuratani
  International Journal of Molecular Sciences.2018; 19(11): 3586.     CrossRef

Type 2 diabetes (T2D) is associated with an increased risk of fracture, which has been reported in several epidemiological studies. However, bone mineral density in T2D is increased and underestimates the fracture risk. Common risk factors for fracture do not fully explain the increased fracture risk observed in patients with T2D. We propose that the pathogenesis of increased fracture risk in T2D is due to low bone turnover caused by osteocyte dysfunction resulting in bone microcracks and fractures. Increased levels of sclerostin may mediate the low bone turnover and may be a novel marker of increased fracture risk, although further research is needed. An impaired incretin response in T2D may also affect bone turnover. Accumulation of advanced glycosylation endproducts may also impair bone strength. Concerning antidiabetic medication, the glitazones are detrimental to bone health and associated with increased fracture risk, and the sulphonylureas may increase fracture risk by causing hypoglycemia. So far, the results on the effect of other antidiabetics are ambiguous. No specific guideline for the management of bone disease in T2D is available and current evidence on the effects of antiosteoporotic medication in T2D is sparse. The aim of this review is to collate current evidence of the pathogenesis, detection and treatment of diabetic bone disease.

Citations

Citations to this article as recorded by  

• Clinical risk factors analysis and prevention of osteoporosis as a complication of diabetes
  Jiaojiao Wang, Hang Li, Haihong Zhu, Xinyan Xie, Qiyue Zheng, Jian Qu, Haiyan Yuan, Ting Liu, Qiong Lu
  International Journal of Diabetes in Developing Countries.2024; 44(4): 711.     CrossRef
• Effects of Exogenous GIP and GLP-2 on Bone Turnover in Individuals With Type 2 Diabetes
  Kirsa Skov-Jeppesen, Charlotte B Christiansen, Laura S Hansen, Johanne A Windeløv, Nora Hedbäck, Lærke S Gasbjerg, Morten Hindsø, Maria S Svane, Sten Madsbad, Jens J Holst, Mette M Rosenkilde, Bolette Hartmann
  The Journal of Clinical Endocrinology & Metabolism.2024; 109(7): 1773.     CrossRef
• The association between type 2 diabetes mellitus/prediabetes status and femoral neck bone mineral density in old adults
  Bo Wang, Chenhao Shi, Zhongxin Zhu
  Journal of Orthopaedic Surgery.2024;[Epub]     CrossRef
• The single point insulin sensitivity estimator (SPISE) is associated with bone health in Arab adults
  Nasser M. Al-Daghri, Kaiser Wani, Malak N. K. Khattak, Abdullah M. Alnaami, Yousef Al-Saleh, Shaun Sabico
  Aging Clinical and Experimental Research.2024;[Epub]     CrossRef
• Single-cell RNA sequencing reveals a distinct profile of bone immune microenvironment and decreased osteoclast differentiation in type 2 diabetic mice
  Zimei Wu, Qiaodan Hou, Heng Chi, Jihong Liu, Yixin Mei, Tingting Chen, Kunkun Yang, Jingna Zheng, Jing Xu, Fuxin Wei, Lin Wang
  Genes & Diseases.2024; 11(6): 101145.     CrossRef
• Assessment of fracture risk in diabetic patients
  Zhenpeng Wang, Mei Zhang, Dan Jia
  Journal of Diabetes & Metabolic Disorders.2024; 23(2): 1653.     CrossRef
• Planetary Health Diet – geeignet für Menschen mit Typ-2-Diabetes?
  Pauline Weimer, Claudia Mews, Dagmar Lühmann, Thomas Kloppe
  Zeitschrift für Allgemeinmedizin.2024; 100(7): 358.     CrossRef
• Bone parameters in T1D and T2D assessed by DXA and HR-pQCT – A cross-sectional study: The DIAFALL study
  Nicklas Højgaard-hessellund Rasmussen, Jakob Dal, Annika Vestergaard Kvist, Joop P. van den Bergh, Morten Hasselstrøm Jensen, Peter Vestergaard
  Bone.2023; 172: 116753.     CrossRef
• Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A Post Hoc Analysis of the U-TURN Trial
  JULIE ABILDGAARD, METTE YUN JOHANSEN, KIRSA SKOV-JEPPESEN, LARS BO ANDERSEN, KRISTIAN KARSTOFT, KATRINE BAGGE HANSEN, BOLETTE HARTMANN, JENS JUUL HOLST, BENTE KLARLUND PEDERSEN, MATHIAS RIED-LARSEN
  Medicine & Science in Sports & Exercise.2022; 54(1): 38.     CrossRef
• The Effects of 12-Weeks Whey Protein Supplements on Markers of Bone Turnover in Adults With Abdominal Obesity – A Post Hoc Analysis
  Rasmus Fuglsang-Nielsen, Elin Rakvaag, Peter Vestergaard, Kjeld Hermansen, Søren Gregersen, Jakob Starup-Linde
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Diabetes and osteoporosis – Treating two entities: A challenge or cause for concern?
  Nicklas H. Rasmussen, Peter Vestergaard
  Best Practice & Research Clinical Rheumatology.2022; 36(3): 101779.     CrossRef
• Do proximal hip geometry, trabecular microarchitecture, and prevalent vertebral fractures differ in postmenopausal women with type 2 diabetes mellitus? A cross-sectional study from a teaching hospital in southern India
  J. Paul, V. Devarapalli, J. T. Johnson, K. E. Cherian, F. K. Jebasingh, H. S. Asha, N. Kapoor, N. Thomas, T. V. Paul
  Osteoporosis International.2021; 32(8): 1585.     CrossRef
• Investigation of Mechanical, Material, and Compositional Determinants of Human Trabecular Bone Quality in Type 2 Diabetes
  Praveer Sihota, Ram Naresh Yadav, Ruban Dhaliwal, Jagadeesh Chandra Bose, Vandana Dhiman, Deepak Neradi, Shailesh Karn, Sidhartha Sharma, Sameer Aggarwal, Vijay G Goni, Vishwajeet Mehandia, Deepak Vashishth, Sanjay Kumar Bhadada, Navin Kumar
  The Journal of Clinical Endocrinology & Metabolism.2021; 106(5): e2271.     CrossRef
• The clinical application of high-resolution peripheral computed tomography (HR-pQCT) in adults: state of the art and future directions
  J.P. van den Bergh, P. Szulc, A.M. Cheung, M. Bouxsein, K. Engelke, R. Chapurlat
  Osteoporosis International.2021; 32(8): 1465.     CrossRef
• Characteristics of bone metabolism in postmenopausal women with newly diagnosed type 2 diabetes mellitus
  Huijuan Li, Yuhua Wen, Peipei Liu, Liya Zhang, Xiaoya Zhang, Yichen Liu, Bin Ma, Haidong Kuang, Jianxin Wang, Lige Song
  Clinical Endocrinology.2021; 95(3): 430.     CrossRef
• Associations between markers of glucose metabolism and bone measures among diabetic and non-diabetic adults
  Kelly Virecoulon Giudici, Natasha Aparecida Grande de França, Bárbara Santarosa Emo Peters, Regina Mara Fisberg, Lígia Araújo Martini
  Journal of Diabetes & Metabolic Disorders.2021; 20(2): 1247.     CrossRef
• Diabetes increases the risk of bone fractures in patients on kidney replacement therapy: A Danish national cohort study
  Sabina Chaudhary Hauge, Bo Abrahamsen, Gunnar Gislason, Jonas Bjerring Olesen, Kristine Hommel, Ditte Hansen
  Bone.2021; 153: 116158.     CrossRef
• Comparison of the Effects of Various Antidiabetic Medication on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus
  Jeonghoon Ha, Yejee Lim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Seung Hyun Ko, Moo Il Kang, Sung Dae Moon, Ki-Hyun Baek
  Endocrinology and Metabolism.2021; 36(4): 895.     CrossRef
• Can fingernail quality predict bone damage in Type 2 diabetes mellitus? a pilot study
  Praveer Sihota, Rimesh Pal, Ram Naresh Yadav, Deepak Neradi, Shailesh Karn, Vijay G. Goni, Siddhartha Sharma, Vishwajeet Mehandia, Sanjay Kumar Bhadada, Navin Kumar, Sudhaker D. Rao, Subburaman Mohan
  PLOS ONE.2021; 16(9): e0257955.     CrossRef
• Do patients with diabetes have an increased risk of impaired fracture healing? A systematic review and meta‐analysis
  Zi‐chuan Ding, Wei‐nan Zeng, Xiao Rong, Zhi‐min Liang, Zong‐ke Zhou
  ANZ Journal of Surgery.2020; 90(7-8): 1259.     CrossRef
• Association between abdominal obesity and fragility fractures among elderly Israeli women
  Orit Ofir, Assaf Buch, Vanessa Rouach, Rebecca Goldsmith, Naftali Stern, Efrat Monsonego-Ornan
  Aging Clinical and Experimental Research.2020; 32(8): 1459.     CrossRef
• Diabetes and fractures: new evidence of atypical femoral fractures?
  N.H. Rasmussen, J. Dal, F. de Vries, J.P. van den Bergh, M.H. Jensen, P. Vestergaard
  Osteoporosis International.2020; 31(3): 447.     CrossRef
• Association of glycaemic variables with trabecular bone score in post‐menopausal women with type 2 diabetes mellitus
  B. Depczynski, P. Y. Liew, C. White
  Diabetic Medicine.2020; 37(9): 1545.     CrossRef
• Understanding Bone Disease in Patients with Diabetic Kidney Disease: a Narrative Review
  Sabina Chaudhary Hauge, Morten Frost, Ditte Hansen
  Current Osteoporosis Reports.2020; 18(6): 727.     CrossRef
• Falls and Fractures in Diabetes—More than Bone Fragility
  Nicklas Højgaard Rasmussen, Jakob Dal
  Current Osteoporosis Reports.2019; 17(3): 147.     CrossRef
• Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes
  Lin Jiating, Ji Buyun, Zhang Yinchang
  BioMed Research International.2019; 2019: 1.     CrossRef
• An update on therapies for the treatment of diabetes-induced osteoporosis
  Sahar Mohsin, May MYH Baniyas, Reem SMH AlDarmaki, Kornélia Tekes, Huba Kalász, Ernest A. Adeghate
  Expert Opinion on Biological Therapy.2019; 19(9): 937.     CrossRef

Citations

Citations to this article as recorded by  

• Clinical and biochemical outcomes after adrenalectomy for primary aldosteronism in tertiary and quaternary referral centers: data from SOPRANO study
  Luigi Marzano, Claudio Ronco
  Hypertension Research.2024; 47(3): 721.     CrossRef
• Catheter-based adrenal ablation: an alternative therapy for patients with aldosterone-producing adenoma
  Fang Sun, Xiaoli Liu, Hexuan Zhang, Xunmei Zhou, Zhigang Zhao, Hongbo He, Zhencheng Yan, Yingsha Li, Qiang Li, Yaoming Li, Jun Jiang, Zhiming Zhu, Hongyun Miao, Zhiyong Li, Ping Wei, Min Long, Xiaoli Chen, Xiaoyun Fan, Wuquan Deng, Yangjie He, Qingbin Lia
  Hypertension Research.2023; 46(1): 91.     CrossRef
• Prognostic models to predict complete resolution of hypertension after adrenalectomy in primary aldosteronism: A systematic review and meta‐analysis
  Luigi Marzano, Amir Kazory, Faeq Husain‐Syed, Claudio Ronco
  Clinical Endocrinology.2023; 99(1): 17.     CrossRef
• Long-term outcome success after operative treatment for primary aldosteronism
  Omar Picado, Bryan W. Whitfield, Zahra F. Khan, Mohammed Jeraq, Josefina C. Farrá, John I. Lew
  Surgery.2021; 169(3): 528.     CrossRef
• Outcomes of Adrenalectomy and the Aldosteronoma Resolution Score in the Black and Hispanic Population
  Gustavo Romero‐Velez, Amanda M. Laird, Manuel E. Barajas, Mauricio Sierra‐Salazar, Miguel F. Herrera, Steven K. Libutti, Michael K. Parides, Xavier Pereira, John C. McAuliffe
  World Journal of Surgery.2021; 45(5): 1475.     CrossRef
• Comparison of cystatin C-based and creatinine-based glomerular filtration rate in the prediction of postoperative residual hypertension in aldosterone-producing adenoma patients after adrenalectomy
  Ching-Way Chen, Cheng-Hsuan Tsai, Chi-Sheng Hung, I-Jung Tsai, Yu-Wei Chiu, Chin-Cheng Chang, Kao-Lang Liu, Shih-Cheng Liao, Vin-Cent Wu, Yen-Hung Lin
  Clinica Chimica Acta.2021; 520: 147.     CrossRef
• Long-term blood pressure outcomes of patients with adrenal venous sampling-proven unilateral primary aldosteronism
  Xu Meng, Wen-Jun Ma, Xiong-Jing Jiang, Pei-Pei Lu, Ying Zhang, Peng Fan, Jun Cai, Hui-Min Zhang, Lei Song, Hai-Ying Wu, Xian-Liang Zhou, Ying Lou
  Journal of Human Hypertension.2020; 34(6): 440.     CrossRef
• Update on the Aldosterone Resolution Score and Lateralization in Patients with Primary Aldosteronism
  Eun-Hee Cho
  Endocrinology and Metabolism.2018; 33(3): 352.     CrossRef

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• Decoding type 2 diabetes mellitus genetic risk variants in Pakistani Pashtun ethnic population using the nascent whole exome sequencing and MassARRAY genotyping: A case-control association study
  Asif Jan, Zakiullah, Sajid Ali, Basir Muhammad, Amina Arshad, Yasar Shah, Haji Bahadur, Hamayun Khan, Fazli Khuda, Rani Akbar, Kiran Ijaz, Giuseppe Novelli
  PLOS ONE.2023; 18(1): e0281070.     CrossRef
• Silencing LncRNA PVT1 Reverses High Glucose-Induced Regulation of the High Expression of PVT1 in HRMECs by Targeting miR-128-3p
  Xuyang Wang, Wangling Chen, Wei Lao, Yunxin Chen
  Hormone and Metabolic Research.2022; 54(02): 119.     CrossRef
• Association of CAPN10 (SNP-19) genetic polymorphism and obesity with T2DM: a study on Bengali Hindu caste population
  Pranabesh Sarkar, Diptendu Chatterjee, Arup Ratan Bandyopadhyay
  International Journal of Diabetes in Developing Countries.2021; 41(1): 37.     CrossRef
• Association of Candidate Gene Polymorphism with Metabolic Syndrome among Mongolian Subjects: A Case-Control Study
  Ariunbold Chuluun-Erdene, Orgil Sengeragchaa, Tsend-Ayush Altangerel, Purevjal Sanjmyatav, Batnaran Dagdan, Solongo Battulga, Lundiamaa Enkhbat, Nyamjav Byambasuren, Munkhzol Malchinkhuu, Munkhtstetseg Janlav
  Medical Sciences.2020; 8(3): 38.     CrossRef
• Meta-analysis of the association between adiponectin SNP 45, SNP 276, and type 2 diabetes mellitus
  Yuwei Dong, Gongping Huang, Xin Wang, Zhaoming Chu, Jingzhi Miao, Houwen Zhou, Mingqing Xu
  PLOS ONE.2020; 15(10): e0241078.     CrossRef
• Association of three SNPs in adiponectin gene with lipid traits of Tianzhu Black Muscovy (Cairina moschata)
  Yuan-Yu Qin, Yi-Yu Zhang, Hua-Lun Luo, Lei Wu
  Molecular Biology Reports.2019; 46(1): 325.     CrossRef

Citations

Citations to this article as recorded by  

• Adequate iodine nutrition and higher salt intake in Chinese adults aged 18–59 years recommended by international organizations
  Diqun Chen, Ying Ye, Ying Lan, Meng He, Jiani Wu, Lijin Wang, Zhihui Chen
  Scientific Reports.2024;[Epub]     CrossRef
• Burden and trends of iodine deficiency in Asia from 1990 to 2019
  R. Wei, Z. Wang, X. Zhang, X. Wang, Y. Xu, Q. Li
  Public Health.2023; 222: 75.     CrossRef
• The Iodine Status and Prevalence of Thyroid Disorders Among Women of Childbearing Age in China: National Cross-sectional Study
  Yongze Li, Zhongyan Shan, Weiping Teng
  Endocrine Practice.2021; 27(10): 1028.     CrossRef
• Female Fertility and the Nutritional Approach: The Most Essential Aspects
  Kinga Skoracka, Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
  Advances in Nutrition.2021; 12(6): 2372.     CrossRef
• Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population
  Songlin Yu, Danchen Wang, Xinqi Cheng, Qiong Zhang, Mingxue Wang, Haipeng Guo, Benzhang Yu, Xiuming Zhang, Liangyu Xia, Dandan Sun, Qian Cheng, Pengchang Li, Yicong Yin, Chaochao Ma, Li'an Hou, Yutong Zou, Honglei Li, Dandan Li, Ling Qiu, Kiyoshi Ichihara
  Clinica Chimica Acta.2020; 502: 34.     CrossRef
• Response: Iodine Status in Filipino Women of Childbearing Age (Endocrinol Metab 2018;33:372-9, Michael E. Serafico et al.)
  Michael E. Serafico
  Endocrinology and Metabolism.2018; 33(4): 495.     CrossRef
• Letter: Iodine Status in Filipino Women of Childbearing Age (Endocrinol Metab 2018;33:372-9, Michael E. Serafico et al.)
  Zheng Feei Ma
  Endocrinology and Metabolism.2018; 33(4): 493.     CrossRef

Citations

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• Autosomal dominant osteopetrosis type II resulting from a de novo mutation in the CLCN7 gene: A case report
  Xiu-Li Song, Li-Yuan Peng, Dao-Wen Wang, Hong Wang
  World Journal of Clinical Cases.2022; 10(20): 6936.     CrossRef
• Magnetic resonance findings in a Cavalier King Charles spaniel with osteopetrosis, Chiari‐like malformation and syringomyelia
  Ricardo Fernandes, C J Jordan, Colin Driver
  Veterinary Record Case Reports.2019;[Epub]     CrossRef

Citations

Citations to this article as recorded by  

• The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review
  Maria Zachou, Pagona Flevari, Narjes Nasiri-Ansari, Constantinos Varytimiadis, Evangelos Kalaitzakis, Eva Kassi, Theodoros Androutsakos
  European Journal of Clinical Pharmacology.2024; 80(1): 127.     CrossRef
• Comparative effectiveness of sodium‐glucose co‐transporter‐2 inhibitors and dipeptidyl peptidase‐4 inhibitors on liver function in patients with type 2 diabetes in Japan: A real‐world data analysis
  Hirokazu Takahashi, Keiko Asakawa, Yoshinori Kosakai, Takumi Lee, Mitsuhiro Rokuda
  Diabetes, Obesity and Metabolism.2024; 26(3): 997.     CrossRef
• Comparison of baseline clinical characteristics among people with type 2 diabetes on second-line therapy previously added with dapagliflozin or another oral glucose-lowering drug: AGORA study
  Vicente Pallarés-Carratalá, Antonio Ruiz-García, Adalberto Serrano-Cumplido, Antonio Segura Fragoso, Verónica Fernández-Pascual, Beatriz Sánchez-Sánchez, María Inmaculada Cervera-Pérez, Francisco Javier Alonso-Moreno, Ezequiel Arranz-Martínez, Alfonso Bar
  Clínica e Investigación en Arteriosclerosis.2024;[Epub]     CrossRef
• Effects of a Combination of Empagliflozin Plus Metformin vs. Metformin Monotherapy on NAFLD Progression in Type 2 Diabetes: The IMAGIN Pilot Study
  Alfredo Caturano, Raffaele Galiero, Giuseppe Loffredo, Erica Vetrano, Giulia Medicamento, Carlo Acierno, Luca Rinaldi, Aldo Marrone, Teresa Salvatore, Marcellino Monda, Celestino Sardu, Raffaele Marfella, Ferdinando Carlo Sasso
  Biomedicines.2023; 11(2): 322.     CrossRef
• Swimming exercise ameliorates insulin resistance and nonalcoholic fatty liver by negatively regulating PPARγ transcriptional network in mice fed high fat diet
  Yong Zhang, Jie Xu, Di Zhou, Tingting Ye, Puqing Zhou, Zuofeng Liu, Xinyuan Liu, Zinan Wang, Tianmiao Hua, Zhenghao Zhang, Qingyan Sun
  Molecular Medicine.2023;[Epub]     CrossRef
• Association between Obstructive Sleep Apnea and Heart Failure in Adults—A Systematic Review
  Agnieszka Polecka, Natalia Olszewska, Łukasz Danielski, Ewa Olszewska
  Journal of Clinical Medicine.2023; 12(19): 6139.     CrossRef
• Prospects of using sodium-glucose co-transporter-2 (SGLT-2) inhibitors in patients with metabolic-associated fatty liver disease (MAFLD)
  Iryna Kostitska, Nadia Protas, Liliia Petrovska
  Diabetes Obesity Metabolic Syndrome.2023; (5): 8.     CrossRef
• Therapeutic outcome of dapagliflozin on various parameters in non-alcoholic fatty liver disease (NAFLD) patients
  Mazhar Hussain, Muhammad Zafar Majeed Babar, Saba Tariq, Muhammad Irfan Ahmad, Lubna Akhtar
  International Journal of Diabetes in Developing Countries.2022; 42(2): 290.     CrossRef
• The safety and efficacy evaluation of sodium-glucose co-transporter 2 inhibitors for patients with non-alcoholic fatty liver disease: An updated meta-analysis
  Manqiu Mo, Zichun Huang, Yuzhen Liang, Yunhua Liao, Ning Xia
  Digestive and Liver Disease.2022; 54(4): 461.     CrossRef
• Dapagliflozin improves steatohepatitis in diabetic rats via inhibition of oxidative stress and inflammation
  Reem M. Hazem, Ahmed Z. Ibrahim, Dina A. Ali, Yasser M. Moustafa
  International Immunopharmacology.2022; 104: 108503.     CrossRef
• SGLT-2 Inhibitors in NAFLD: Expanding Their Role beyond Diabetes and Cardioprotection
  Theodoros Androutsakos, Narjes Nasiri-Ansari, Athanasios-Dimitrios Bakasis, Ioannis Kyrou, Efstathios Efstathopoulos, Harpal S. Randeva, Eva Kassi
  International Journal of Molecular Sciences.2022; 23(6): 3107.     CrossRef
• Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice
  Panshuang Qiao, Yingli Jia, Ang Ma, Jinzhao He, Chen Shao, Xiaowei Li, Shuyuan Wang, Baoxue Yang, Hong Zhou
  Frontiers in Pharmacology.2022;[Epub]     CrossRef
• Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial
  Yumie Takeshita, Masao Honda, Kenichi Harada, Yuki Kita, Noboru Takata, Hiromasa Tsujiguchi, Takeo Tanaka, Hisanori Goto, Yujiro Nakano, Noriho Iida, Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Hiroyuki Nakamura, Shuichi Kaneko, Toshinari Takamura
  Diabetes Care.2022; 45(9): 2064.     CrossRef
• Heart Failure with Preserved Ejection Fraction and Obstructive Sleep Apnea: A Novel Paradigm for Additional Cardiovascular Benefit of SGLT2 Inhibitors in Subjects With or Without Type 2 Diabetes
  Vincenzo Maria Monda, Sandro Gentile, Francesca Porcellati, Ersilia Satta, Alessandro Fucili, Marcello Monesi, Felice Strollo
  Advances in Therapy.2022; 39(11): 4837.     CrossRef
• Metformin, pioglitazone, dapagliflozin and their combinations ameliorate manifestations associated with NAFLD in rats via anti-inflammatory, anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms
  Hager H. Shaaban, Ibrahim Alzaim, Ahmed El-Mallah, Rania G. Aly, Ahmed F. El-Yazbi, Ahmed Wahid
  Life Sciences.2022; 308: 120956.     CrossRef
• The impact of sodium glucose co‐transporter 2 inhibitors on non‐alcoholic fatty liver disease
  Lampros Chrysavgis, Alkistis‐Maria Papatheodoridi, Antonios Chatzigeorgiou, Evangelos Cholongitas
  Journal of Gastroenterology and Hepatology.2021; 36(4): 893.     CrossRef
• Sodium-Glucose Co-Transporter 2 Inhibitors for Non-Alcoholic Fatty Liver Disease in Asian Patients With Type 2 Diabetes: A Meta-Analysis
  Chloe Wong, Clyve Yu Leon Yaow, Cheng Han Ng, Yip Han Chin, Yi Fen Low, Amanda Yuan Ling Lim, Mark Dhinesh Muthiah, Chin Meng Khoo
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Effects of sodium‐glucose co‐transporter 2 inhibitors on liver parameters and steatosis: A meta‐analysis of randomized clinical trials
  Francisca dos Santos Coelho, Marta Borges‐Canha, Madalena von Hafe, João Sérgio Neves, Catarina Vale, Ana Rita Leite, Davide Carvalho, Adelino Leite‐Moreira
  Diabetes/Metabolism Research and Reviews.2021;[Epub]     CrossRef
• Effects of anti-diabetic treatments in type 2 diabetes and fatty liver disease
  Elizabeth M. Lamos, Megan Kristan, Maka Siamashvili, Stephen N. Davis
  Expert Review of Clinical Pharmacology.2021; 14(7): 837.     CrossRef
• Sodium-Glucose Cotransporter-2 Inhibitors Ameliorate Liver Enzyme Abnormalities in Korean Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease
  Won Euh, Soo Lim, Jin-Wook Kim
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Dapagliflozin attenuates steatosis in livers of high-fat diet-induced mice and oleic acid-treated L02 cells via regulating AMPK/mTOR pathway
  Jingyi Luo, Pengbo Sun, Yangyang Wang, Yang Chen, Yaoyun Niu, Yipei Ding, Naihan Xu, Yaou Zhang, Weidong Xie
  European Journal of Pharmacology.2021; 907: 174304.     CrossRef
• The effects of dapagliflozin on hepatic and visceral fat in type 2 diabetes patients with non‐alcoholic fatty liver disease
  Susrichit Phrueksotsai, Kanokwan Pinyopornpanish, Juntima Euathrongchit, Apinya Leerapun, Arintaya Phrommintikul, Supawan Buranapin, Nipon Chattipakorn, Satawat Thongsawat
  Journal of Gastroenterology and Hepatology.2021; 36(10): 2952.     CrossRef
• Possible Preventative/Rehabilitative Role of Gliflozins in OSA and T2DM. A Systematic Literature Review-Based Hypothesis
  Vincenzo Maria Monda, Francesca Porcellati, Felice Strollo, Alessandro Fucili, Marcello Monesi, Ersilia Satta, Sandro Gentile
  Advances in Therapy.2021; 38(8): 4195.     CrossRef
• Sodium‐glucose co‐transporter 2 inhibitors reduce hepatic events in diabetic patients with chronic hepatitis B
  Lilian Yan Liang, Vincent Wai‐Sun Wong, Vicki Wing‐Ki Hui, Terry Cheuk‐Fung Yip, Yee‐Kit Tse, Grace Chung‐Yan Lui, Henry Lik‐Yuen Chan, Grace Lai‐Hung Wong
  GastroHep.2021; 3(4): 261.     CrossRef
• Effects of Metformin on Hepatic Steatosis in Adults with Nonalcoholic Fatty Liver Disease and Diabetes: Insights from the Cellular to Patient Levels
  Kanokwan Pinyopornpanish, Apinya Leerapun, Kanokporn Pinyopornpanish, Nipon Chattipakorn
  Gut and Liver.2021; 15(6): 827.     CrossRef
• The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease
  F. Anthony Romero, Christopher T. Jones, Yingzi Xu, Martijn Fenaux, Randall L. Halcomb
  Journal of Medicinal Chemistry.2020; 63(10): 5031.     CrossRef
• SGLT2 Inhibitors in Liver Patients
  John Chen Hsiang, Vincent Wai-Sun Wong
  Clinical Gastroenterology and Hepatology.2020; 18(10): 2168.     CrossRef
• Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease
  Kyung-Soo Kim, Byung-Wan Lee
  Clinical and Molecular Hepatology.2020; 26(4): 430.     CrossRef
• Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics
  Stergios A. Polyzos, Jannis Kountouras, Christos S. Mantzoros
  Metabolism.2019; 92: 82.     CrossRef
• Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment
  Kyung-Soo Kim, Byung-Wan Lee, Yong Jin Kim, Dae Ho Lee, Bong-Soo Cha, Cheol-Young Park
  Diabetes & Metabolism Journal.2019; 43(2): 127.     CrossRef
• Concurrent exercise improves insulin resistance and nonalcoholic fatty liver disease by upregulating PPAR-γ and genes involved in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat diet
  Fan Zheng, Ying Cai
  Lipids in Health and Disease.2019;[Epub]     CrossRef
• The Effects of Hypoglycemic Agents on Non-alcoholic Fatty Liver Disease: Focused on Sodium-Glucose Cotransporter 2 Inhibitors and Glucagon-Like Peptide-1 Receptor Agonists
  Chan-Hee Jung, Ji-Oh Mok
  Journal of Obesity & Metabolic Syndrome.2019; 28(1): 18.     CrossRef
• Effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors on non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: Ex quo et quo vadimus?
  Niki Katsiki, Nikolaos Perakakis, Christos Mantzoros
  Metabolism.2019; 98: iii.     CrossRef
• Empaglifozin mitigates NAFLD in high-fat-fed mice by alleviating insulin resistance, lipogenesis and ER stress
  Tamiris Ingrid Petito-da-Silva, Vanessa Souza-Mello, Sandra Barbosa-da-Silva
  Molecular and Cellular Endocrinology.2019; 498: 110539.     CrossRef
• Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: A common comorbidity associated with severe complications
  A.J. Scheen
  Diabetes & Metabolism.2019; 45(3): 213.     CrossRef

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• Exposure to and Transplacental Transfer of Per- and Polyfluoroalkyl Substances in a Twin Pregnancy Cohort in Korea
  Na-Youn Park, Sun Wook Cho, Ye Eun Seo, Heeyeon Chae, Inae Lee, Young Ah Lee, Jong Kwan Jun, Eun Na Kim, Jeong-Won Oh, Kyungho Choi, Younglim Kho
  Environmental Science & Technology.2024; 58(48): 21120.     CrossRef
• High intakes of iodine among women during pregnancy and the postpartum period has no adverse effect on thyroid function
  Dal Lae Ju, Sun Wook Cho, Chae Won Chung, Young Ah Lee, Gi Jeong Cheon, Young Joo Park, Choong Ho Shin, Jong Kwan Jun, June-Key Chung, Sue K. Park, YoonJu Song
  European Journal of Nutrition.2023; 62(1): 239.     CrossRef
• Associations between maternal thyroid function in pregnancy and child neurodevelopmental outcomes at 20 months in the Seychelles Child Development Study, Nutrition Cohort 2 (SCDS NC2)
  Anna M. Monaghan, Maria S. Mulhern, Emeir M. Mc Sorley, J.J. Strain, Theresa Winter, Edwin van Wijngaarden, Gary J. Myers, Philip W. Davidson, Conrad Shamlaye, Jude Gedeon, Alison J. Yeates
  Journal of Nutritional Science.2021;[Epub]     CrossRef

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• Mitochondrial Cristae Morphology Reflecting Metabolism, Superoxide Formation, Redox Homeostasis, and Pathology
  Petr Ježek, Martin Jabůrek, Blanka Holendová, Hana Engstová, Andrea Dlasková
  Antioxidants & Redox Signaling.2023; 39(10-12): 635.     CrossRef
• Sphingolipids in mitochondria—from function to disease
  Maryam Jamil, Lauren Ashley Cowart
  Frontiers in Cell and Developmental Biology.2023;[Epub]     CrossRef
• Sphingosine‐1‐phosphate in mitochondrial function and metabolic diseases
  Meng Duan, Pan Gao, Sheng‐xi Chen, Petr Novák, Kai Yin, Xiao Zhu
  Obesity Reviews.2022;[Epub]     CrossRef
• Involvement of miR‐27a‐3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress
  Lina Wu, Qingzhu Wang, Feng Guo, Xiaojun Ma, Jiao Wang, Yanyan Zhao, Yushan Yan, Guijun Qin
  Journal of Cellular Physiology.2021; 236(2): 1454.     CrossRef
• Sphingosine‐1‐phosphate in acute exercise and training
  Katarzyna Hodun, Adrian Chabowski, Marcin Baranowski
  Scandinavian Journal of Medicine & Science in Sports.2021; 31(5): 945.     CrossRef
• The Ethyl Acetate Extract From Celastrus orbiculatus Promotes Apoptosis of Gastric Cancer Cells Through Mitochondria Regulation by PHB
  Lide Tao, Zixin Yin, Tengyang Ni, Zewen Chu, Shihua Hao, Zeyu Wang, Masataka Sunagawa, Haibo Wang, Yanqing Liu
  Frontiers in Pharmacology.2021;[Epub]     CrossRef
• Sphingosine 1-phosphate Stimulates Insulin Secretion and Improves Cell Survival by Blocking Voltage-dependent K+ Channels in β Cells
  Zhihong Liu, Huanhuan Yang, Linping Zhi, Huan Xue, Zhihong Lu, Yanli Zhao, Lijuan Cui, Tao Liu, Shouan Ren, Peifeng He, Yunfeng Liu, Yi Zhang
  Frontiers in Pharmacology.2021;[Epub]     CrossRef
• Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity
  Yadi Tang, Thomas Plötz, Markus H. Gräler, Ewa Gurgul-Convey
  International Journal of Molecular Sciences.2021; 22(19): 10893.     CrossRef
• Sphingolipids and Mitochondrial Dynamic
  Lais Brigliadori Fugio, Fernanda B. Coeli-Lacchini, Andréia Machado Leopoldino
  Cells.2020; 9(3): 581.     CrossRef
• Diminished Sphingolipid Metabolism, a Hallmark of Future Type 2 Diabetes Pathogenesis, Is Linked to Pancreatic β Cell Dysfunction
  Saifur R. Khan, Yousef Manialawy, Andreea Obersterescu, Brian J. Cox, Erica P. Gunderson, Michael B. Wheeler
  iScience.2020; 23(10): 101566.     CrossRef
• Neuronal Metabolism and Neuroprotection: Neuroprotective Effect of Fingolimod on Menadione-Induced Mitochondrial Damage
  Antonio Gil, Elisa Martín-Montañez, Nadia Valverde, Estrella Lara, Federica Boraldi, Silvia Claros, Silvana-Yanina Romero-Zerbo, Oscar Fernández, Jose Pavia, Maria Garcia-Fernandez
  Cells.2020; 10(1): 34.     CrossRef
• WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction
  Zijian Fang, Susan Pyne, Nigel J. Pyne
  Progress in Lipid Research.2019; : 100991.     CrossRef
• Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic β-cells
  Petr Ježek, Andrea Dlasková
  Mitochondrion.2019; 49: 245.     CrossRef
• Sphingosine kinase 1 overexpression induces MFN2 fragmentation and alters mitochondrial matrix Ca2+ handling in HeLa cells
  I. Pulli, C. Löf, T. Blom, M.Y. Asghar, T. Lassila, N. Bäck, K.-L. Lin, J.H. Nyström, K. Kemppainen, D.M. Toivola, E. Dufour, A. Sanz, H.M. Cooper, J.B. Parys, K. Törnquist
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2019; 1866(9): 1475.     CrossRef
• Ceramide and sphingosine 1-phosphate in adipose dysfunction
  Zijian Fang, Susan Pyne, Nigel J. Pyne
  Progress in Lipid Research.2019; 74: 145.     CrossRef
• S1P/S1P Receptor Signaling in Neuromuscolar Disorders
  Elisabetta Meacci, Mercedes Garcia-Gil
  International Journal of Molecular Sciences.2019; 20(24): 6364.     CrossRef

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  Li-Zhen Dai, Hong Ma, Jian-Fang Ke, Chen-Shi Lin, Yanling Huang, Yuan Tian, Danling Chen
  Women's Health.2022;[Epub]     CrossRef
• Novel mutations of the CYP17A1 gene in four Chinese 46,XX cases with partial 17a-hydroxylase/17,20-lyase deficiency
  Yanjie Xia, Panlai Shi, Junke Xia, Huijuan Zhang, Lijun Xu, Xiangdong Kong
  Steroids.2021; 173: 108873.     CrossRef